STRINGSTRING
AKT2 AKT2 EGF EGF LEF1 LEF1 AXIN2 AXIN2 MAPK10 MAPK10 EREG EREG AREG AREG GRB2 GRB2 PIK3R2 PIK3R2 DDB2 DDB2 RPS6KB1 RPS6KB1 MAPK3 MAPK3 GSK3B GSK3B BAD BAD GADD45G GADD45G RAC2 RAC2 KRAS KRAS BRAF BRAF MAPK9 MAPK9 CCND1 CCND1 AKT3 AKT3 BAK1 BAK1 RAF1 RAF1 TGFBR2 TGFBR2 AKT1 AKT1 MYC MYC MAPK8 MAPK8 CDKN1A CDKN1A MAP2K2 MAP2K2 HRAS HRAS TGFBR1 TGFBR1 PIK3CB PIK3CB TP53 TP53 GADD45B GADD45B TGFB3 TGFB3 FOS FOS SOS1 SOS1 APPL1 APPL1 AXIN1 AXIN1 PIK3CA PIK3CA MAP2K1 MAP2K1 SMAD3 SMAD3 MSH2 MSH2 MSH6 MSH6 ARAF ARAF MAPK1 MAPK1 MLH1 MLH1 APC APC MSH3 MSH3 RHOA RHOA TGFA TGFA SOS2 SOS2 RALA RALA POLK POLK PIK3R1 PIK3R1 EGFR EGFR TCF7L1 TCF7L1 RALB RALB CTNNB1 CTNNB1 SMAD2 SMAD2 SMAD4 SMAD4 DCC DCC BCL2 BCL2 TGFB1 TGFB1 CASP3 CASP3 BBC3 BBC3 BAX BAX BIRC5 BIRC5 RAC3 RAC3 NRAS NRAS GADD45A GADD45A PIK3R3 PIK3R3 MTOR MTOR PIK3CD PIK3CD JUN JUN APC2 APC2 ENSCSAP00000018835 ENSCSAP00000018835
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase. (535 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
LEF1Lymphoid enhancer binding factor 1. (331 aa)
AXIN2Axin 2. (843 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
EREGEpiregulin. (171 aa)
AREGAmphiregulin. (252 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R2Uncharacterized protein. (629 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
BADBCL2 associated agonist of cell death. (167 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
RAC2Rac family small GTPase 2. (192 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (482 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (709 aa)
AXIN1Axin 1. (867 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (933 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1360 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
MLH1MutL homolog 1. (756 aa)
APCAPC regulator of WNT signaling pathway. (2861 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1125 aa)
RHOARas homolog family member A. (193 aa)
TGFATransforming growth factor alpha. (158 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
RALARAS like proto-oncogene A. (206 aa)
POLKDNA polymerase kappa. (847 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
TCF7L1Transcription factor 7 like 1. (442 aa)
RALBRAS like proto-oncogene B. (206 aa)
CTNNB1Catenin beta 1. (781 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
DCCDCC netrin 1 receptor. (1420 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
BBC3Uncharacterized protein. (199 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
BIRC5Uncharacterized protein. (142 aa)
RAC3Rac family small GTPase 3. (192 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
APC2APC regulator of WNT signaling pathway 2. (1685 aa)
ENSCSAP00000018835Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.