STRINGSTRING
AKT2 AKT2 PAK1 PAK1 PAK4 PAK4 RAP1B RAP1B GRB2 GRB2 PIK3R2 PIK3R2 EP300 EP300 RBX1 RBX1 MAPK3 MAPK3 PDGFB PDGFB BAD BAD PAK6 PAK6 KRAS KRAS BRAF BRAF FLCN FLCN PAK3 PAK3 AKT3 AKT3 FH FH RAF1 RAF1 CREBBP CREBBP AKT1 AKT1 VHL VHL EGLN1 EGLN1 CDKN1A CDKN1A ELOB ELOB MAP2K2 MAP2K2 MET MET HRAS HRAS PIK3CB PIK3CB CUL2 CUL2 HGF HGF TGFB3 TGFB3 VEGFA VEGFA SOS1 SOS1 PIK3CA PIK3CA TFE3 TFE3 MAP2K1 MAP2K1 CRKL CRKL EPAS1 EPAS1 ELOC ELOC PAK5 PAK5 ARAF ARAF MAPK1 MAPK1 CRK CRK HIF1A HIF1A RAPGEF1 RAPGEF1 ARNT2 ARNT2 TGFA TGFA SOS2 SOS2 EGLN3 EGLN3 PIK3R1 PIK3R1 ARNT ARNT EGLN2 EGLN2 TGFB1 TGFB1 GAB1 GAB1 PTPN11 PTPN11 ETS1 ETS1 PRCC PRCC NRAS NRAS RAP1A RAP1A PIK3R3 PIK3R3 SLC2A1 SLC2A1 CDC42 CDC42 PIK3CD PIK3CD JUN JUN ENSCSAP00000018734 ENSCSAP00000018734
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase. (535 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
PAK4Non-specific serine/threonine protein kinase. (633 aa)
RAP1BUncharacterized protein. (184 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R2Uncharacterized protein. (629 aa)
EP300E1A binding protein p300. (2416 aa)
RBX1Ring-box 1. (108 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
BADBCL2 associated agonist of cell death. (167 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (482 aa)
FLCNFolliculin. (579 aa)
PAK3Non-specific serine/threonine protein kinase. (559 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
FHFumarate hydratase. (510 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
CREBBPCREB binding protein. (2417 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
VHLVon Hippel-Lindau tumor suppressor. (213 aa)
EGLN1Egl-9 family hypoxia inducible factor 1. (426 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ELOBUbiquitin-like domain-containing protein. (118 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1381 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
CUL2Cullin 2; Belongs to the cullin family. (842 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (575 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
EPAS1Endothelial PAS domain protein 1. (869 aa)
ELOCElongin C; Belongs to the SKP1 family. (112 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CRKCRK proto-oncogene, adaptor protein. (204 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1264 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (717 aa)
TGFATransforming growth factor alpha. (158 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (405 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
ETS1ETS proto-oncogene 1, transcription factor. (441 aa)
PRCCProline rich mitotic checkpoint control factor. (491 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (416 aa)
CDC42Cell division cycle 42. (191 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
ENSCSAP00000018734Ubiquitin-like domain-containing protein. (118 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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