STRINGSTRING
AKT2 AKT2 EGF EGF LEF1 LEF1 CDH1 CDH1 AXIN2 AXIN2 ILK ILK GRB2 GRB2 PIK3R2 PIK3R2 DDB2 DDB2 MAPK3 MAPK3 PTEN PTEN GSK3B GSK3B BAD BAD GADD45G GADD45G CTNNA3 CTNNA3 KRAS KRAS BRAF BRAF CCND1 CCND1 AKT3 AKT3 BAK1 BAK1 RAF1 RAF1 AKT1 AKT1 MYC MYC CDKN1A CDKN1A MAP2K2 MAP2K2 HRAS HRAS PIK3CB PIK3CB TP53 TP53 GADD45B GADD45B SOS1 SOS1 AXIN1 AXIN1 PIK3CA PIK3CA CTNNA1 CTNNA1 MAP2K1 MAP2K1 ELK1 ELK1 ARAF ARAF MAPK1 MAPK1 MLH1 MLH1 APC APC FOXO3 FOXO3 SOS2 SOS2 POLK POLK CTNNA2-2 CTNNA2-2 PIK3R1 PIK3R1 EGFR EGFR TCF7L1 TCF7L1 CTNNB1 CTNNB1 PDPK1 PDPK1 BAX BAX ERBB2 ERBB2 NRAS NRAS GADD45A GADD45A PIK3R3 PIK3R3 PIK3CD PIK3CD APC2 APC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase. (535 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
LEF1Lymphoid enhancer binding factor 1. (331 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
AXIN2Axin 2. (843 aa)
ILKIntegrin linked kinase. (452 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R2Uncharacterized protein. (629 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
BADBCL2 associated agonist of cell death. (167 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
CTNNA3Uncharacterized protein. (305 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (482 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
AXIN1Axin 1. (867 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CTNNA1Catenin alpha 1. (906 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ELK1Uncharacterized protein. (296 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
MLH1MutL homolog 1. (756 aa)
APCAPC regulator of WNT signaling pathway. (2861 aa)
FOXO3Forkhead box O3. (672 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
POLKDNA polymerase kappa. (847 aa)
CTNNA2-2Uncharacterized protein. (376 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
TCF7L1Transcription factor 7 like 1. (442 aa)
CTNNB1Catenin beta 1. (781 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (580 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
APC2APC regulator of WNT signaling pathway 2. (1685 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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