STRINGSTRING
AKT2 AKT2 EGF EGF PRKCA PRKCA MDM2 MDM2 CDK4 CDK4 GRB2 GRB2 PDGFRA PDGFRA PIK3R2 PIK3R2 DDB2 DDB2 MAPK3 MAPK3 PDGFB PDGFB PRKCB PRKCB PTEN PTEN GADD45G GADD45G SHC3 SHC3 E2F3 E2F3 KRAS KRAS BRAF BRAF CAMK2G CAMK2G CCND1 CCND1 AKT3 AKT3 BAK1 BAK1 RAF1 RAF1 ENSCSAP00000005944 ENSCSAP00000005944 AKT1 AKT1 CDKN1A CDKN1A SHC4 SHC4 CAMK1 CAMK1 MAP2K2 MAP2K2 HRAS HRAS PIK3CB PIK3CB TP53 TP53 CALM1 CALM1 GADD45B GADD45B CAMK2A CAMK2A PDGFRB PDGFRB E2F1 E2F1 SOS1 SOS1 CDK6 CDK6 PIK3CA PIK3CA SHC2 SHC2 MAP2K1 MAP2K1 CAMK1D CAMK1D CALML4 CALML4 ARAF ARAF MAPK1 MAPK1 PLCG1 PLCG1 CAMK4 CAMK4 TGFA TGFA SOS2 SOS2 CAMK1G CAMK1G POLK POLK CAMK2B CAMK2B PIK3R1 PIK3R1 EGFR EGFR IGF1R IGF1R PDGFA PDGFA RB1 RB1 PLCG2 PLCG2 IGF1 IGF1 BAX BAX PRKCG PRKCG NRAS NRAS GADD45A GADD45A PIK3R3 PIK3R3 E2F2 E2F2 MTOR MTOR PIK3CD PIK3CD CALML5 CALML5 CALML3 CALML3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase. (535 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (620 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
PIK3R2Uncharacterized protein. (629 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
SHC3SHC adaptor protein 3. (598 aa)
E2F3E2F_CC-MB domain-containing protein. (224 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (482 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (588 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
ENSCSAP00000005944Uncharacterized protein. (173 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
SHC4SHC adaptor protein 4. (630 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (478 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
E2F1E2F transcription factor 1. (437 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SHC2Uncharacterized protein. (590 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID. (288 aa)
CALML4Calmodulin like 4. (194 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PLCG1Phosphoinositide phospholipase C. (974 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (614 aa)
TGFATransforming growth factor alpha. (158 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (476 aa)
POLKDNA polymerase kappa. (847 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (628 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
IGF1RTyrosine-protein kinase receptor. (1064 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
RB1RB transcriptional corepressor 1. (928 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
IGF1Insulin like growth factor 1. (159 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
E2F2E2F transcription factor 2. (437 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CALML5Calmodulin like 5. (146 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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