STRINGSTRING
AKT2 AKT2 EGF EGF LEF1 LEF1 NFKB1 NFKB1 MDM2 MDM2 FGFR2 FGFR2 GRB2 GRB2 PDGFRA PDGFRA CDK2 CDK2 PIK3R2 PIK3R2 CREB3L1 CREB3L1 CHUK CHUK EP300 EP300 MAPK3 MAPK3 ATF4 ATF4 PDGFB PDGFB IKBKG IKBKG PTEN PTEN GSK3B GSK3B BAD BAD SPINT1 SPINT1 E2F3 E2F3 KRAS KRAS RELA RELA BRAF BRAF TMPRSS2 TMPRSS2 ERG ERG CDKN1B CDKN1B GSTP1 GSTP1 CREB3L2 CREB3L2 PLAU PLAU CCND1 CCND1 AKT3 AKT3 RAF1 RAF1 CREBBP CREBBP AKT1 AKT1 INS INS CREB1 CREB1 HSP90AA1 HSP90AA1 CDKN1A CDKN1A CREB3 CREB3 CREB3L3 CREB3L3 MAP2K2 MAP2K2 HRAS HRAS PIK3CB PIK3CB TP53 TP53 SRD5A2 SRD5A2 ZEB1 ZEB1 PDGFRB PDGFRB AR AR E2F1 E2F1 SOS1 SOS1 HSP90AB1 HSP90AB1 PIK3CA PIK3CA MAP2K1 MAP2K1 ARAF ARAF MAPK1 MAPK1 ETV5 ETV5 CREB5 CREB5 MMP9 MMP9 IKBKB IKBKB PLAT PLAT TGFA TGFA SOS2 SOS2 NFKBIA NFKBIA PIK3R1 PIK3R1 EGFR EGFR TCF7L1 TCF7L1 NKX3-1 NKX3-1 CTNNB1 CTNNB1 IGF1R IGF1R IL1R2 IL1R2 PDGFA PDGFA RB1 RB1 FOXO1 FOXO1 BCL2 BCL2 PDPK1 PDPK1 IGF1 IGF1 PDGFC PDGFC MMP3 MMP3 PDGFD PDGFD HSP90B1 HSP90B1 ERBB2 ERBB2 KLK3 KLK3 NRAS NRAS PIK3R3 PIK3R3 E2F2 E2F2 MTOR MTOR PIK3CD PIK3CD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase. (535 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
LEF1Lymphoid enhancer binding factor 1. (331 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
PIK3R2Uncharacterized protein. (629 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
EP300E1A binding protein p300. (2416 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ATF4Activating transcription factor 4. (351 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (374 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
BADBCL2 associated agonist of cell death. (167 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (513 aa)
E2F3E2F_CC-MB domain-containing protein. (224 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (482 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (492 aa)
ERGETS transcription factor ERG. (479 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
GSTP1Glutathione S-transferase pi 1. (383 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
PLAUPlasminogen activator, urokinase. (437 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
CREBBPCREB binding protein. (2417 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
HSP90AA1HATPase_c domain-containing protein. (387 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (311 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1124 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
ARAndrogen receptor. (900 aa)
E2F1E2F transcription factor 1. (437 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ETV5ETS variant 5. (510 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (501 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
TGFATransforming growth factor alpha. (158 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
TCF7L1Transcription factor 7 like 1. (442 aa)
NKX3-1NK3 homeobox 1. (232 aa)
CTNNB1Catenin beta 1. (781 aa)
IGF1RTyrosine-protein kinase receptor. (1064 aa)
IL1R2Interleukin 1 receptor type 2. (418 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
RB1RB transcriptional corepressor 1. (928 aa)
FOXO1Forkhead box O1. (655 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (580 aa)
IGF1Insulin like growth factor 1. (159 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
PDGFDPlatelet derived growth factor D. (332 aa)
HSP90B1Heat shock protein 90 beta family member 1. (804 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
KLK3Peptidase S1 domain-containing protein. (122 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
E2F2E2F transcription factor 2. (437 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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