STRINGSTRING
FGF2 FGF2 AKT2 AKT2 EGF EGF CDH1 CDH1 MDM2 MDM2 FGF5 FGF5 CDK4 CDK4 PDGFRA PDGFRA PIK3R2 PIK3R2 FGF8 FGF8 DDB2 DDB2 MAPK3 MAPK3 PDGFB PDGFB PTEN PTEN BAD BAD GADD45G GADD45G E2F3 E2F3 KRAS KRAS BRAF BRAF CCND1 CCND1 FGF19 FGF19 FGF4 FGF4 FGF3 FGF3 AKT3 AKT3 BAK1 BAK1 RAF1 RAF1 FGF18 FGF18 ENSCSAP00000005944 ENSCSAP00000005944 AKT1 AKT1 CDKN1A CDKN1A FGF7 FGF7 MAP2K2 MAP2K2 FGF16 FGF16 MET MET HRAS HRAS FGF6 FGF6 FGF23 FGF23 PIK3CB PIK3CB TP53 TP53 GADD45B GADD45B MITF MITF PDGFRB PDGFRB HGF HGF E2F1 E2F1 FGF1 FGF1 CDK6 CDK6 FGF22 FGF22 PIK3CA PIK3CA MAP2K1 MAP2K1 ARAF ARAF MAPK1 MAPK1 POLK POLK PIK3R1 PIK3R1 EGFR EGFR FGF17 FGF17 FGF10 FGF10 FGF20 FGF20 IGF1R IGF1R PDGFA PDGFA RB1 RB1 FGF9 FGF9 IGF1 IGF1 PDGFC PDGFC PDGFD PDGFD FGF21 FGF21 BAX BAX NRAS NRAS GADD45A GADD45A PIK3R3 PIK3R3 E2F2 E2F2 PIK3CD PIK3CD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
AKT2Non-specific serine/threonine protein kinase. (535 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
PIK3R2Uncharacterized protein. (629 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
BADBCL2 associated agonist of cell death. (167 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
E2F3E2F_CC-MB domain-containing protein. (224 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (482 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ENSCSAP00000005944Uncharacterized protein. (173 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (115 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1381 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
MITFMelanocyte inducing transcription factor. (520 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
E2F1E2F transcription factor 1. (437 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
POLKDNA polymerase kappa. (847 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (333 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
IGF1RTyrosine-protein kinase receptor. (1064 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
RB1RB transcriptional corepressor 1. (928 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
IGF1Insulin like growth factor 1. (159 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
PDGFDPlatelet derived growth factor D. (332 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
E2F2E2F transcription factor 2. (437 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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