STRINGSTRING
EGF EGF CDH1 CDH1 MDM2 MDM2 CDK4 CDK4 CXCL8 CXCL8 TYMP TYMP MMP2 MMP2 UPK3A UPK3A MAPK3 MAPK3 THBS1 THBS1 DAPK1 DAPK1 E2F3 E2F3 KRAS KRAS BRAF BRAF CCND1 CCND1 RAF1 RAF1 ENSCSAP00000005944 ENSCSAP00000005944 MYC MYC CDKN1A CDKN1A MAP2K2 MAP2K2 DAPK3 DAPK3 HRAS HRAS TP53 TP53 RPS6KA5 RPS6KA5 VEGFA VEGFA E2F1 E2F1 DAPK2 DAPK2 HBEGF HBEGF MAP2K1 MAP2K1 ARAF ARAF MAPK1 MAPK1 SRC SRC RASSF1 RASSF1 MMP9 MMP9 FGFR3 FGFR3 EGFR EGFR RB1 RB1 MMP1 MMP1 ERBB2 ERBB2 NRAS NRAS E2F2 E2F2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
TYMPThymidine phosphorylase; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (482 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
UPK3AUroplakin 3A. (240 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
THBS1Thrombospondin 1. (1170 aa)
DAPK1Death associated protein kinase 1. (1440 aa)
E2F3E2F_CC-MB domain-containing protein. (224 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (482 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
ENSCSAP00000005944Uncharacterized protein. (173 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
DAPK3Death associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
RPS6KA5Ribosomal protein S6 kinase. (776 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
E2F1E2F transcription factor 1. (437 aa)
DAPK2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (225 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
SRCTyrosine-protein kinase. (633 aa)
RASSF1Ras association domain family member 1. (345 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
FGFR3Fibroblast growth factor receptor. (806 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
RB1RB transcriptional corepressor 1. (928 aa)
MMP1Matrix metallopeptidase 1. (469 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
E2F2E2F transcription factor 2. (437 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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