STRINGSTRING
AKT2 AKT2 GAB2 GAB2 NFKB1 NFKB1 MDM2 MDM2 CTBP2 CTBP2 CDK4 CDK4 GRB2 GRB2 PIK3R2 PIK3R2 CHUK CHUK DDB2 DDB2 MAPK3 MAPK3 IKBKG IKBKG BAD BAD GADD45G GADD45G SHC3 SHC3 E2F3 E2F3 KRAS KRAS RELA RELA BRAF BRAF CDKN1B CDKN1B RUNX1 RUNX1 CCND1 CCND1 AKT3 AKT3 BAK1 BAK1 RAF1 RAF1 TGFBR2 TGFBR2 ENSCSAP00000005944 ENSCSAP00000005944 AKT1 AKT1 MYC MYC CDKN1A CDKN1A SHC4 SHC4 MAP2K2 MAP2K2 HRAS HRAS TGFBR1 TGFBR1 PIK3CB PIK3CB TP53 TP53 GADD45B GADD45B TGFB3 TGFB3 E2F1 E2F1 SOS1 SOS1 MECOM MECOM CDK6 CDK6 BCL2L1 BCL2L1 PIK3CA PIK3CA SHC2 SHC2 MAP2K1 MAP2K1 CRKL CRKL SMAD3 SMAD3 ARAF ARAF MAPK1 MAPK1 CRK CRK BCR BCR ABL1 ABL1 IKBKB IKBKB SOS2 SOS2 POLK POLK NFKBIA NFKBIA CTBP1 CTBP1 HDAC2 HDAC2 PIK3R1 PIK3R1 RB1 RB1 SMAD4 SMAD4 TGFB1 TGFB1 STAT5A STAT5A STAT5B STAT5B BAX BAX CBL CBL PTPN11 PTPN11 ENSCSAP00000016053 ENSCSAP00000016053 NRAS NRAS GADD45A GADD45A PIK3R3 PIK3R3 HDAC1 HDAC1 E2F2 E2F2 PIK3CD PIK3CD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase. (535 aa)
GAB2GRB2 associated binding protein 2. (638 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
CTBP2Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (386 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R2Uncharacterized protein. (629 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (374 aa)
BADBCL2 associated agonist of cell death. (167 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
SHC3SHC adaptor protein 3. (598 aa)
E2F3E2F_CC-MB domain-containing protein. (224 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (482 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (456 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
ENSCSAP00000005944Uncharacterized protein. (173 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
SHC4SHC adaptor protein 4. (630 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
E2F1E2F transcription factor 1. (437 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MECOMMDS1 and EVI1 complex locus. (1051 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
BCL2L1BCL2 like 1. (233 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SHC2Uncharacterized protein. (590 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CRKCRK proto-oncogene, adaptor protein. (204 aa)
BCRBCR activator of RhoGEF and GTPase. (1064 aa)
ABL1Tyrosine-protein kinase. (1130 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
POLKDNA polymerase kappa. (847 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (421 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
RB1RB transcriptional corepressor 1. (928 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
STAT5ASignal transducer and activator of transcription. (798 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
CBLCbl proto-oncogene. (907 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
ENSCSAP00000016053Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (497 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
E2F2E2F transcription factor 2. (437 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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