STRINGSTRING
CCNA2 CCNA2 AKT2 AKT2 DUSP6 DUSP6 LEF1 LEF1 NFKB1 NFKB1 GRB2 GRB2 KIT KIT PIK3R2 PIK3R2 CHUK CHUK MPO MPO ITGAM ITGAM RPS6KB1 RPS6KB1 PER2 PER2 MAPK3 MAPK3 IKBKG IKBKG BAD BAD KRAS KRAS RELA RELA BRAF BRAF RUNX1 RUNX1 CCND1 CCND1 AKT3 AKT3 RAF1 RAF1 AKT1 AKT1 MYC MYC PIM1 PIM1 MAP2K2 MAP2K2 HRAS HRAS PIK3CB PIK3CB CSF1R CSF1R SOS1 SOS1 CD14 CD14 RUNX1T1 RUNX1T1 PIK3CA PIK3CA PIM2 PIM2 MAP2K1 MAP2K1 ARAF ARAF MAPK1 MAPK1 CSF2 CSF2 IL3 IL3 PML PML IKBKB IKBKB BCL2A1 BCL2A1 SOS2 SOS2 EIF4EBP1 EIF4EBP1 PIK3R1 PIK3R1 TCF7L1 TCF7L1 CEBPE CEBPE CCNA1 CCNA1 FLT3 FLT3 LOC103247163 LOC103247163 STAT3 STAT3 STAT5A STAT5A STAT5B STAT5B JUP JUP RARA RARA ZBTB16 ZBTB16 NRAS NRAS PIK3R3 PIK3R3 MTOR MTOR PIK3CD PIK3CD CEBPA CEBPA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
AKT2Non-specific serine/threonine protein kinase. (535 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
LEF1Lymphoid enhancer binding factor 1. (331 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
PIK3R2Uncharacterized protein. (629 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
MPOMyeloperoxidase. (746 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1151 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PER2Period circadian regulator 2. (1254 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (374 aa)
BADBCL2 associated agonist of cell death. (167 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (482 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (456 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (974 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
RUNX1T1RUNX1 partner transcriptional co-repressor 1. (577 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PIM2Pim-2 proto-oncogene, serine/threonine kinase. (199 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CSF2Colony stimulating factor 2. (144 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (143 aa)
PMLPromyelocytic leukemia. (819 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
BCL2A1BCL2 related protein A1. (175 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
EIF4EBP1Uncharacterized protein. (118 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
TCF7L1Transcription factor 7 like 1. (442 aa)
CEBPECCAAT/enhancer-binding protein. (281 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (974 aa)
LOC103247163Uncharacterized protein. (357 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
STAT5ASignal transducer and activator of transcription. (798 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
JUPJunction plakoglobin. (745 aa)
RARARetinoic acid receptor alpha. (462 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CEBPACCAAT enhancer binding protein alpha. (356 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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