STRINGSTRING
AKT2 AKT2 EGF EGF PRKCA PRKCA CDK4 CDK4 GRB2 GRB2 PIK3R2 PIK3R2 JAK3 JAK3 DDB2 DDB2 MAPK3 MAPK3 PRKCB PRKCB BAD BAD GADD45G GADD45G E2F3 E2F3 KRAS KRAS BRAF BRAF CCND1 CCND1 AKT3 AKT3 RXRB RXRB BAK1 BAK1 RAF1 RAF1 ENSCSAP00000005944 ENSCSAP00000005944 AKT1 AKT1 RARB RARB CDKN1A CDKN1A RXRG RXRG MAP2K2 MAP2K2 ALK ALK MET MET HRAS HRAS PIK3CB PIK3CB TP53 TP53 GADD45B GADD45B HGF HGF FHIT FHIT E2F1 E2F1 SOS1 SOS1 EML4 EML4 CDK6 CDK6 PIK3CA PIK3CA MAP2K1 MAP2K1 ARAF ARAF MAPK1 MAPK1 PLCG1 PLCG1 RASSF1 RASSF1 STK4 STK4 RASSF5 RASSF5 TGFA TGFA FOXO3 FOXO3 SOS2 SOS2 POLK POLK RXRA RXRA PIK3R1 PIK3R1 EGFR EGFR RB1 RB1 PDPK1 PDPK1 PLCG2 PLCG2 STAT3 STAT3 STAT5A STAT5A STAT5B STAT5B BAX BAX ERBB2 ERBB2 PRKCG PRKCG NRAS NRAS GADD45A GADD45A PIK3R3 PIK3R3 E2F2 E2F2 PIK3CD PIK3CD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase. (535 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (620 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R2Uncharacterized protein. (629 aa)
JAK3Tyrosine-protein kinase. (1069 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
BADBCL2 associated agonist of cell death. (167 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
E2F3E2F_CC-MB domain-containing protein. (224 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (482 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
RXRBRetinoid X receptor beta. (533 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
ENSCSAP00000005944Uncharacterized protein. (173 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RARBRetinoic acid receptor beta. (448 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
RXRGRetinoid X receptor gamma. (463 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ALKTyrosine-protein kinase receptor. (1192 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1381 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
FHITHIT domain-containing protein. (130 aa)
E2F1E2F transcription factor 1. (437 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
EML4EMAP like 4. (980 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PLCG1Phosphoinositide phospholipase C. (974 aa)
RASSF1Ras association domain family member 1. (345 aa)
STK4Serine/threonine kinase 4. (487 aa)
RASSF5Ras association domain family member 5. (265 aa)
TGFATransforming growth factor alpha. (158 aa)
FOXO3Forkhead box O3. (672 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
POLKDNA polymerase kappa. (847 aa)
RXRARetinoid X receptor alpha. (462 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
RB1RB transcriptional corepressor 1. (928 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (580 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
STAT5ASignal transducer and activator of transcription. (798 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
E2F2E2F transcription factor 2. (437 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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