STRINGSTRING
AKT2 AKT2 FGFR2 FGFR2 PDGFRA PDGFRA KIT KIT LDHAL6A LDHAL6A LDHC LDHC GLS2 GLS2 PIK3R2 PIK3R2 MAPK3 MAPK3 PFKM PFKM G6PD G6PD PTEN PTEN KRAS KRAS PFKL PFKL HKDC1 HKDC1 HK1 HK1 LDHB LDHB HK3 HK3 AKT3 AKT3 RAF1 RAF1 AKT1 AKT1 IDH1 IDH1 MYC MYC SIRT6 SIRT6 MAP2K2 MAP2K2 MET MET RET RET HRAS HRAS PIK3CB PIK3CB TIGAR TIGAR SIRT3 SIRT3 TP53 TP53 PDGFRB PDGFRB PDHB PDHB GLS GLS SLC2A2 SLC2A2 PIK3CA PIK3CA MAP2K1 MAP2K1 MAPK1 MAPK1 PFKP PFKP HIF1A HIF1A PDK1 PDK1 PGAM2 PGAM2 GCK GCK FGFR3 FGFR3 HK2 HK2 PIK3R1 PIK3R1 EGFR EGFR LDHA LDHA IDH2 IDH2 NTRK3 NTRK3 FLT3 FLT3 SLC7A5 SLC7A5 SLC1A5 SLC1A5 ERBB2 ERBB2 NTRK1 NTRK1 SLC16A3 SLC16A3 NRAS NRAS PIK3R3 PIK3R3 SLC2A1 SLC2A1 MTOR MTOR PIK3CD PIK3CD PDHA2 PDHA2 LOC103230363 LOC103230363 ENSCSAP00000018170 ENSCSAP00000018170 ENSCSAP00000018380 ENSCSAP00000018380 SCO2 SCO2 LDHAL6B LDHAL6B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase. (535 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
LDHAL6AL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
LDHCL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (216 aa)
GLS2Glutaminase 2. (602 aa)
PIK3R2Uncharacterized protein. (629 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (515 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
HK1Hexokinase 1. (917 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
HK3Hexokinase 3. (923 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
SIRT6Sirtuin 6. (355 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1381 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1099 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (399 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
GLSGlutaminase. (669 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (807 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
PDK1Protein-serine/threonine kinase. (436 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
GCKPhosphotransferase. (466 aa)
FGFR3Fibroblast growth factor receptor. (806 aa)
HK2Hexokinase 2. (917 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (343 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
NTRK3Tyrosine-protein kinase receptor. (850 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (974 aa)
SLC7A5Solute carrier family 7 member 5. (507 aa)
SLC1A5Amino acid transporter. (276 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
SLC16A3Solute carrier family 16 member 3. (465 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (416 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (388 aa)
LOC103230363Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
ENSCSAP00000018170Pyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
ENSCSAP00000018380Uncharacterized protein. (254 aa)
SCO2SCO cytochrome c oxidase assembly protein 2. (266 aa)
LDHAL6BL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (381 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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