STRINGSTRING
AKT2 AKT2 MAP3K3 MAP3K3 EGF EGF NFKBIB NFKBIB NFKB1 NFKB1 NFATC3 NFATC3 PPP3CA PPP3CA IFNG IFNG MAP2K6 MAP2K6 CSNK2A2 CSNK2A2 MAPK11 MAPK11 PIK3R2 PIK3R2 TRAF6 TRAF6 CHUK CHUK RPS6KB1 RPS6KB1 MAPK3 MAPK3 LAT LAT IKBKG IKBKG PTEN PTEN RASGRP1 RASGRP1 BATF2 BATF2 MAP2K3 MAP2K3 KRAS KRAS ENSCSAP00000004095 ENSCSAP00000004095 RELA RELA CSNK2B CSNK2B PPP3CB PPP3CB JAK2 JAK2 CD274 CD274 AKT3 AKT3 RAF1 RAF1 AKT1 AKT1 IFNGR2 IFNGR2 PTPN6 PTPN6 MAPK14 MAPK14 MAPK13 MAPK13 CD4 CD4 CD28 CD28 CSNK2A1 CSNK2A1 MAP2K2 MAP2K2 ALK ALK CD247 CD247 HRAS HRAS PIK3CB PIK3CB BATF BATF FOS FOS STAT1 STAT1 NFKBIE NFKBIE EML4 EML4 PIK3CA PIK3CA TLR4 TLR4 MAP2K1 MAP2K1 PRKCQ PRKCQ MAPK1 MAPK1 LOC103227720 LOC103227720 PLCG1 PLCG1 HIF1A HIF1A MYD88 MYD88 PPP3R1 PPP3R1 IKBKB IKBKB NFATC2 NFATC2 BATF3 BATF3 NFKBIA NFKBIA PIK3R1 PIK3R1 EGFR EGFR IFNGR1 IFNGR1 ZAP70 ZAP70 NFATC1 NFATC1 STAT3 STAT3 CD3E CD3E CD3D CD3D CD3G CD3G PTPN11 PTPN11 TIRAP TIRAP NRAS NRAS JAK1 JAK1 PIK3R3 PIK3R3 MTOR MTOR PIK3CD PIK3CD TICAM2 TICAM2 TLR2 TLR2 JUN JUN TICAM1 TICAM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase. (535 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
NFATC3RHD domain-containing protein. (637 aa)
PPP3CASerine/threonine-protein phosphatase. (471 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
PIK3R2Uncharacterized protein. (629 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (538 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
LATLinker for activation of T cells. (235 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (374 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
RASGRP1RAS guanyl releasing protein 1. (659 aa)
BATF2Basic leucine zipper ATF-like transcription factor 2. (308 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ENSCSAP00000004095Ig-like domain-containing protein. (166 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (228 aa)
PPP3CBSerine/threonine-protein phosphatase. (534 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
CD274CD274 molecule. (291 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IFNGR2Interferon gamma receptor 2. (341 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CD4CD4 molecule. (560 aa)
CD28CD28 molecule. (220 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ALKTyrosine-protein kinase receptor. (1192 aa)
CD247CD247 molecule. (165 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
NFKBIENFKB inhibitor epsilon. (361 aa)
EML4EMAP like 4. (980 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (745 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
LOC103227720TIR domain-containing protein. (1032 aa)
PLCG1Phosphoinositide phospholipase C. (974 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
PPP3R1Protein phosphatase 3 regulatory subunit B, alpha. (170 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
NFATC2Nuclear factor of activated T cells 2. (928 aa)
BATF3Basic leucine zipper ATF-like transcription factor 3. (129 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
IFNGR1Interferon gamma receptor 1. (491 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
NFATC1Nuclear factor of activated T cells 1. (929 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
CD3ECD3e molecule. (197 aa)
CD3DCD3d molecule. (171 aa)
CD3GCD3g molecule. (209 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
TIRAPTIR domain containing adaptor protein. (220 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
TICAM2Toll like receptor adaptor molecule 2. (235 aa)
TLR2Toll-like receptor. (784 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (711 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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