STRINGSTRING
AKT2 AKT2 ITGB3 ITGB3 PECAM1 PECAM1 NFKB1 NFKB1 NQO1 NQO1 IFNG IFNG MAPK10 MAPK10 MAP2K6 MAP2K6 CDH5 CDH5 SUMO2 SUMO2 MAPK11 MAPK11 KDR KDR GSTO2 GSTO2 GSTO1 GSTO1 MMP2 MMP2 PIK3R2 PIK3R2 CHUK CHUK KLF2 KLF2 GPC1 GPC1 CCL2 CCL2 PDGFB PDGFB NPPC NPPC IKBKG IKBKG NOS3 NOS3 KEAP1 KEAP1 ICAM1 ICAM1 CTSL CTSL EDN1 EDN1 SUMO3 SUMO3 RAC2 RAC2 MAPK7 MAPK7 TXN2 TXN2 RELA RELA SDC1 SDC1 MAP2K7 MAP2K7 HMOX1 HMOX1 MAPK9 MAPK9 MGST1 MGST1 SQSTM1 SQSTM1 GSTP1 GSTP1 MAP2K4 MAP2K4 AKT3 AKT3 DUSP1 DUSP1 BMPR1A BMPR1A AKT1 AKT1 MAPK8 MAPK8 MAPK14 MAPK14 MAPK13 MAPK13 HSP90AA1 HSP90AA1 NOX1 NOX1 BMPR2 BMPR2 TNFRSF1A TNFRSF1A MGST3 MGST3 CAV3 CAV3 CAV1 CAV1 CAV2 CAV2 LOC103223040 LOC103223040 ENSCSAP00000007185 ENSCSAP00000007185 PIK3CB PIK3CB SELE SELE TP53 TP53 CALM1 CALM1 VEGFA VEGFA FOS FOS HSP90AB1 HSP90AB1 ITGAV ITGAV NCF2 NCF2 PIK3CA PIK3CA GSTA1 GSTA1 GSTA2 GSTA2 ENSCSAP00000009288 ENSCSAP00000009288 GSTA4 GSTA4 MAP2K5 MAP2K5 CALML4 CALML4 SRC SRC NFE2L2 NFE2L2 SDC4 SDC4 ACVR2B ACVR2B MMP9 MMP9 ASS1 ASS1 BMP4 BMP4 IKBKB IKBKB PLAT PLAT RHOA RHOA PIK3R1 PIK3R1 ACVR1 ACVR1 ACVR2A ACVR2A IL1B IL1B IL1A IL1A MAP3K5 MAP3K5 CTNNB1 CTNNB1 PRKAA1 PRKAA1 IL1R1 IL1R1 IL1R2 IL1R2 MAP3K7 MAP3K7 PDGFA PDGFA BCL2 BCL2 NCF1 NCF1 ENSCSAP00000014297 ENSCSAP00000014297 ITGA2B ITGA2B MGST2 MGST2 HSP90B1 HSP90B1 CYBA CYBA TRPV4 TRPV4 RAC3 RAC3 ARHGEF2 ARHGEF2 GSTM3 GSTM3 GSTM5 GSTM5 GSTM4 GSTM4 VCAM1 VCAM1 PRKAA2 PRKAA2 PIK3R3 PIK3R3 PIK3CD PIK3CD PRKCZ PRKCZ JUN JUN SUMO1 SUMO1 THBD THBD TXN TXN CALML5 CALML5 CALML3 CALML3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase. (535 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (741 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (738 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (255 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (785 aa)
SUMO2Small ubiquitin-related modifier. (95 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (215 aa)
GSTO1Uncharacterized protein; Belongs to the GST superfamily. (241 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
PIK3R2Uncharacterized protein. (629 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
KLF2Kruppel like factor 2. (355 aa)
GPC1Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (558 aa)
CCL2C-C motif chemokine. (99 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
NPPCNatriuretic peptide C. (126 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (374 aa)
NOS3Nitric oxide synthase 3. (867 aa)
KEAP1Kelch like ECH associated protein 1. (624 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (333 aa)
EDN1Endothelin 1. (211 aa)
SUMO3Small ubiquitin-related modifier. (110 aa)
RAC2Rac family small GTPase 2. (192 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
TXN2Thioredoxin 2. (166 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (517 aa)
HMOX1Heme oxygenase 1. (288 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
SQSTM1Sequestosome 1. (440 aa)
GSTP1Glutathione S-transferase pi 1. (383 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (363 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
HSP90AA1HATPase_c domain-containing protein. (387 aa)
NOX1NADPH oxidase 1. (564 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
MGST3Microsomal glutathione S-transferase 3. (152 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
LOC103223040Uncharacterized protein. (240 aa)
ENSCSAP00000007185Uncharacterized protein; Belongs to the GST superfamily. (195 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
SELESelectin E. (610 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GSTA1Glutathione S-transferase alpha 1. (222 aa)
GSTA2Glutathione S-transferase alpha 2; Belongs to the GST superfamily. (222 aa)
ENSCSAP00000009288Uncharacterized protein; Belongs to the GST superfamily. (224 aa)
GSTA4Glutathione S-transferase alpha 4. (222 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
CALML4Calmodulin like 4. (194 aa)
SRCTyrosine-protein kinase. (633 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (198 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (354 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
ASS1Uncharacterized protein. (140 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
RHOARas homolog family member A. (193 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (224 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1219 aa)
CTNNB1Catenin beta 1. (781 aa)
PRKAA1Non-specific serine/threonine protein kinase. (501 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
IL1R2Interleukin 1 receptor type 2. (418 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
ENSCSAP00000014297Uncharacterized protein; Belongs to the peptidase C1 family. (262 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1039 aa)
MGST2Microsomal glutathione S-transferase 2. (147 aa)
HSP90B1Heat shock protein 90 beta family member 1. (804 aa)
CYBACytochrome b-245 alpha chain. (197 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (824 aa)
RAC3Rac family small GTPase 3. (192 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (978 aa)
GSTM3Glutathione S-transferase. (225 aa)
GSTM5Glutathione S-transferase mu 5. (218 aa)
GSTM4Glutathione S-transferase mu 4. (218 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. (488 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
THBDThrombomodulin. (626 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
CALML5Calmodulin like 5. (146 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.