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acs acs ilvD ilvD ccsB ccsB ilvE ilvE accA accA fumB fumB HTH_0308 HTH_0308 ccl ccl ackA ackA ilvB ilvB ilvH ilvH leuD leuD acnA acnA mdh mdh fumA fumA HTH_0792 HTH_0792 leuA leuA icd icd frdB frdB korB korB korA korA forA forA forB forB forG forG forE forE HTH_1106 HTH_1106 HTH_1130 HTH_1130 acyP acyP citA citA frdA frdA pycA pycA frdD frdD leuB leuB porG porG porB porB porA porA pycB pycB accD accD ilvC ilvC ppsA ppsA accB accB ccsA ccsA frdE frdE sucD sucD sucC sucC leuC leuC frdC frdC accC accC
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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acsAcyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (631 aa)
ilvDDihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (555 aa)
ccsBcitryl-CoA synthetase small subunit. (344 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (305 aa)
accAacetyl-CoA carboxylase alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (316 aa)
fumBFumarate hydratase beta subunit. (185 aa)
HTH_0308Iron-containing alcohol dehydrogenase. (387 aa)
cclcitryl-CoA lyase. (259 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (358 aa)
ilvBAcetolactate synthase large subunit. (584 aa)
ilvHAcetolactate synthase small subunit. (189 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (167 aa)
acnAAconitate hydratase/aconitase. (660 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (334 aa)
fumAFumarate hydratase alpha subunit. (281 aa)
HTH_0792Aldehyde dehydrogenase. (477 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (519 aa)
icdIsocitrate dehydrogenase; Oxalosuccinate reductase. (421 aa)
frdBFumarate reductase subunit B. (225 aa)
korB2-oxoglutarate:ferredoxin oxidoreductase beta subunit. (295 aa)
korA2-oxoglutarate:ferredoxin oxidoreductase alpha subunit. (607 aa)
forA2-oxoglutarate:ferredoxin oxidoreductase alpha subunit. (389 aa)
forB2-oxoglutarate:ferredoxin oxidoreductase beta subunit. (288 aa)
forG2-oxoglutarate:ferredoxin oxidoreductase gamma subunit. (227 aa)
forE2-oxoglutarate:ferredoxin oxidoreductase epsilon subunit, ferredoxin-like protein. (74 aa)
HTH_1106Succinate dehydrogenase/fumarate reductase iron-sulfur protein. (237 aa)
HTH_1130Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (325 aa)
acyPAcylphosphatase. (90 aa)
citACitramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (527 aa)
frdAFumarate reductase subunit A. (568 aa)
pycAPyruvate carboxylase large subunit. (617 aa)
frdDFumarate reductase subunit D. (463 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (364 aa)
porGPyruvate:ferredoxin oxidoreductase gamma subunit. (237 aa)
porBPyruvate:ferredoxin oxidoreductase beta subunit. (286 aa)
porAPyruvate:ferredoxin oxidoreductase alpha subunit. (400 aa)
pycBPyruvate carboxylase small subunit. (475 aa)
accDacetyl-CoA carboxyltransferase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (280 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa)
ppsAPhosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (853 aa)
accBBiotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (146 aa)
ccsAcitryl-CoA synthetase large subunit. (429 aa)
frdEFumarate reductase subunit E. (183 aa)
sucDsuccinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (293 aa)
sucCsuccinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (383 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (428 aa)
frdCFumarate reductase subunit C. (522 aa)
accCBiotin carboxylase. (444 aa)
Your Current Organism:
Hydrogenobacter thermophilus
NCBI taxonomy Id: 608538
Other names: H. thermophilus TK-6, Hydrogenobacter thermophilus DSM 6534, Hydrogenobacter thermophilus TK-6, Hydrogenobacter thermophilus str. TK-6, Hydrogenobacter thermophilus strain TK-6
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