(62 nodes) RNA phosphodiester bond hydrolysis, endonucleolytic network (Harpegnathos saltator)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EAI_15071	Integrator complex subunit 11. (594 aa)
	EAI_08331	Ribonuclease H1. (235 aa)
	EAI_07662	Probable RNA 3'-terminal phosphate cyclase-like protein. (374 aa)
	EAI_10260	Serine/threonine-protein kinase/endoribonuclease ire-1. (246 aa)
	EAI_01364	tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] (424 aa)
	EAI_03617	Placental protein 11. (798 aa)
	EAI_03618	Placental protein 11. (615 aa)
	EAI_16950	Endonuclease G, mitochondrial. (623 aa)
	EAI_00369	Translin-associated protein X. (302 aa)
	EAI_06087	Eukaryotic translation initiation factor 2C 2. (1125 aa)
	EAI_01328	Uncharacterized protein C1orf26-like protein. (742 aa)
	EAI_03303	Serine/threonine-protein kinase/endoribonuclease IRE1. (217 aa)
	EAI_03304	Serine/threonine-protein kinase/endoribonuclease IRE1. (319 aa)
	EAI_00179	Protein KRI1-like protein. (586 aa)
	EAI_07228	Zinc finger CCCH domain-containing protein 12C. (157 aa)
	EAI_11289	Eukaryotic translation initiation factor 2C 2; Belongs to the argonaute family. (921 aa)
	EAI_15114	Ribonuclease 3. (1328 aa)
	EAI_14805	Activator of basal transcription 1. (236 aa)
	EAI_17412	Uncharacterized protein. (196 aa)
	EAI_17413	Ribonuclease P protein subunit p21. (144 aa)
	EAI_12384	Ribosome biogenesis protein BMS1-like protein. (832 aa)
	EAI_16693	Ribonuclease kappa. (97 aa)
	EAI_01196	Nucleolar protein 9. (841 aa)
	EAI_04180	Probable U3 small nucleolar RNA-associated protein 13. (809 aa)
	EAI_15733	Ribosome biogenesis protein BMS1-like protein. (1268 aa)
	EAI_17142	Ribonuclease P protein subunit p40. (218 aa)
	EAI_17143	Ribonuclease P protein subunit p40. (146 aa)
	EAI_17144	RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (461 aa)
	EAI_10231	rRNA-processing protein UTP23-like protein. (256 aa)
	EAI_05979	Protein piwi; Belongs to the argonaute family. (777 aa)
	EAI_00265	Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (386 aa)
	EAI_15861	Lariat debranching enzyme. (483 aa)
	EAI_07289	Ribonucleases P/MRP protein subunit POP1. (872 aa)
	EAI_02039	Uncharacterized protein. (73 aa)
	EAI_02040	tRNA-splicing endonuclease subunit Sen34. (96 aa)
	EAI_09288	Pre-rRNA-processing protein TSR1-like protein. (801 aa)
	EAI_09400	Zinc finger CCCH domain-containing protein 12C. (678 aa)
	EAI_12309	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (312 aa)
	EAI_11442	Probable phospholipase D family member FLJ33580-like protein. (125 aa)
	EAI_03826	Pumilio domain-containing protein C14orf21. (608 aa)
	EAI_04451	Uncharacterized protein. (123 aa)
	EAI_15180	Cleavage and polyadenylation specificity factor subunit 4. (285 aa)
	EAI_06477	Ribonuclease Z, mitochondrial. (897 aa)
	EAI_06494	Exosome complex exonuclease RRP44. (977 aa)
	EAI_10711	Cleavage and polyadenylation specificity factor subunit 3. (685 aa)
	EAI_10722	Placental protein 11. (477 aa)
	EAI_10723	Placental protein 11. (727 aa)
	EAI_10997	Protein KRI1-like protein. (780 aa)
	EAI_04875	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (337 aa)
	EAI_09822	Endoribonuclease dcr-1. (1479 aa)
	EAI_13080	Endonuclease_NS domain-containing protein. (404 aa)
	EAI_00796	Ribonuclease Oy; Belongs to the RNase T2 family. (202 aa)
	EAI_07567	Uncharacterized protein KIAA0391. (535 aa)
	EAI_00974	Protein piwi; Belongs to the argonaute family. (770 aa)
	EAI_14979	Beta-lactamase-like protein 2-like protein. (298 aa)
	EAI_04066	Endoribonuclease Dcr-1; Belongs to the helicase family. Dicer subfamily. (1807 aa)
	EAI_14470	Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. (155 aa)
	EAI_12666	Eukaryotic translation initiation factor 2C 2. (659 aa)
	EAI_02830	Telomerase-binding protein EST1A. (603 aa)
	EAI_02831	Telomerase-binding protein EST1A. (1232 aa)
	EAI_03866	Piwi-like protein 1. (174 aa)
	EAI_06901	Beta-lactamase-like protein LOC255374-like protein. (212 aa)

Your Current Organism:

Harpegnathos saltator

NCBI taxonomy Id: 610380
Other names: H. saltator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EAI_00179	EAI_04180	E2BCZ2	E2BIS4	Protein KRI1-like protein.	Probable U3 small nucleolar RNA-associated protein 13.	0.468
EAI_00179	EAI_07289	E2BCZ2	E2BN83	Protein KRI1-like protein.	Ribonucleases P/MRP protein subunit POP1.	0.695
EAI_00179	EAI_07662	E2BCZ2	E2B4Q9	Protein KRI1-like protein.	Probable RNA 3'-terminal phosphate cyclase-like protein.	0.642
EAI_00179	EAI_09288	E2BCZ2	E2BPW1	Protein KRI1-like protein.	Pre-rRNA-processing protein TSR1-like protein.	0.520
EAI_00179	EAI_10231	E2BCZ2	E2BKU6	Protein KRI1-like protein.	rRNA-processing protein UTP23-like protein.	0.750
EAI_00179	EAI_12309	E2BCZ2	E2BR14	Protein KRI1-like protein.	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	0.499
EAI_00179	EAI_12384	E2BCZ2	E2BGB6	Protein KRI1-like protein.	Ribosome biogenesis protein BMS1-like protein.	0.584
EAI_00179	EAI_14805	E2BCZ2	E2BFS2	Protein KRI1-like protein.	Activator of basal transcription 1.	0.501
EAI_00179	EAI_15733	E2BCZ2	E2BKC7	Protein KRI1-like protein.	Ribosome biogenesis protein BMS1-like protein.	0.584
EAI_00179	EAI_17144	E2BCZ2	E2BKQ7	Protein KRI1-like protein.	RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family.	0.511
EAI_00179	EAI_17412	E2BCZ2	E2BG90	Protein KRI1-like protein.	Uncharacterized protein.	0.443
EAI_00179	EAI_17413	E2BCZ2	E2BG91	Protein KRI1-like protein.	Ribonuclease P protein subunit p21.	0.443
EAI_00369	EAI_06087	E2BA24	E2BAF4	Translin-associated protein X.	Eukaryotic translation initiation factor 2C 2.	0.740
EAI_00369	EAI_11289	E2BA24	E2BDN9	Translin-associated protein X.	Eukaryotic translation initiation factor 2C 2; Belongs to the argonaute family.	0.772
EAI_00369	EAI_12666	E2BA24	E2C544	Translin-associated protein X.	Eukaryotic translation initiation factor 2C 2.	0.597
EAI_01196	EAI_06494	E2BGQ7	E2BW43	Nucleolar protein 9.	Exosome complex exonuclease RRP44.	0.478
EAI_01196	EAI_13080	E2BGQ7	E2BZU5	Nucleolar protein 9.	Endonuclease_NS domain-containing protein.	0.413
EAI_01364	EAI_02039	E2B775	E2BNN8	tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...]	Uncharacterized protein.	0.841
EAI_01364	EAI_02040	E2B775	E2BNN9	tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...]	tRNA-splicing endonuclease subunit Sen34.	0.904
EAI_01364	EAI_17142	E2B775	E2BKQ5	tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...]	Ribonuclease P protein subunit p40.	0.506