STRINGSTRING
MAPK3 MAPK3 RAC1 RAC1 GNB2 GNB2 RAC3 RAC3 ELK1 ELK1 GRIN2A GRIN2A ANGPT4 ANGPT4 RGL1 RGL1 RASGRP4 RASGRP4 SHC1 SHC1 FGF21 FGF21 PAK3 PAK3 ENSLCNP00005028782 ENSLCNP00005028782 PRKCA PRKCA ADAM15 ADAM15 FASLG FASLG CALML6 CALML6 GNB1 GNB1 EFNA4 EFNA4 ENSLCNP00005027979 ENSLCNP00005027979 EFNA3 EFNA3 EFNA1 EFNA1 GNG4 GNG4 RASSF5 RASSF5 RAP1A RAP1A BCL2L1 BCL2L1 ENSLCNP00005026793 ENSLCNP00005026793 LAT LAT AKT2 AKT2 PRKCG PRKCG MAPK8 MAPK8 ENSLCNP00005026019 ENSLCNP00005026019 FOXO4 FOXO4 RASA4B RASA4B ANGPT1 ANGPT1 PLA2G12B PLA2G12B PVALEF PVALEF RASA2 RASA2 PIK3CB PIK3CB GNG13 GNG13 MRAS MRAS PLA2G10 PLA2G10 PLCG2 PLCG2 FGF3 FGF3 FGF4 FGF4 FGF19 FGF19 RRAS RRAS PLA1A PLA1A KRAS KRAS RAB17 RAB17 ENSLCNP00005023008 ENSLCNP00005023008 ENSLCNP00005023001 ENSLCNP00005023001 TRBV18 TRBV18 ENSLCNP00005022959 ENSLCNP00005022959 TRBV13 TRBV13 ENSLCNP00005022936 ENSLCNP00005022936 ENSLCNP00005022927 ENSLCNP00005022927 ENSLCNP00005022920 ENSLCNP00005022920 ENSLCNP00005022908 ENSLCNP00005022908 ENSLCNP00005022895 ENSLCNP00005022895 HRAS HRAS CSF1 CSF1 MAPK1 MAPK1 PLD2 PLD2 NF1 NF1 KSR1 KSR1 NTRK2 NTRK2 PLA2G3 PLA2G3 GRIN1 GRIN1 FGFR2 FGFR2 RELA RELA SHOC2 SHOC2 LOC115526480 LOC115526480 INS INS RAB5C RAB5C CDC42 CDC42 CEP152 CEP152 SHC4 SHC4 RALBP1 RALBP1 GALK2 GALK2 SHC3 SHC3 CHUK CHUK RIN1 RIN1 PLA2G2C PLA2G2C PLA2G2F PLA2G2F PLA2G2D PLA2G2D PLA2G5 PLA2G5 FGF8 FGF8 PLA2G2E PLA2G2E RAB5A RAB5A RASGRP2 RASGRP2 ENSLCNP00005018044 ENSLCNP00005018044 PAK2 PAK2 GNB5 GNB5 GNG10 GNG10 HTR7 HTR7 ENSLCNP00005017177 ENSLCNP00005017177 PAK1 PAK1 PDGFD PDGFD BAD BAD BRAP BRAP RRAS2 RRAS2 PPP1R14B PPP1R14B VEGFB VEGFB GNB4 GNB4 GAB2 GAB2 PIK3CA PIK3CA PTPN11 PTPN11 ETS2 ETS2 ENSLCNP00005015940 ENSLCNP00005015940 ENSLCNP00005015924 ENSLCNP00005015924 ANGPT2 ANGPT2 GNG14 GNG14 PIK3R1 PIK3R1 RAC2 RAC2 LOC115519995 LOC115519995 GNG12 GNG12 ETS1 ETS1 PIK3CD PIK3CD GNG2 GNG2 RASGRF1 RASGRF1 RAPGEF5 RAPGEF5 GRIN2B GRIN2B RHOA RHOA GNG5 GNG5 PRKACB PRKACB TIAM1 TIAM1 PGF PGF HGF HGF RPS6KL1 RPS6KL1 ENSLCNP00005011486 ENSLCNP00005011486 FGF10 FGF10 GAB1 GAB1 TGFA TGFA SOS2 SOS2 ARF6 ARF6 PDGFB PDGFB AFDN AFDN FGFR4 FGFR4 EXOC2 EXOC2 IGF1 IGF1 PLA2G6 PLA2G6 ENSLCNP00005009418 ENSLCNP00005009418 ENSLCNP00005009362 ENSLCNP00005009362 ENSLCNP00005009348 ENSLCNP00005009348 PDGFRB PDGFRB PIK3R2 PIK3R2 RASGRP1 RASGRP1 PDGFC PDGFC EFNA5 EFNA5 REL REL FGF5 FGF5 IGF1R IGF1R RALA RALA CALML3 CALML3 CALML5 CALML5 EGFR EGFR PAK6 PAK6 RAB5B RAB5B FGF22 FGF22 MET MET FGF20 FGF20 CALML4 CALML4 ENSLCNP00005006752 ENSLCNP00005006752 FGFR1 FGFR1 FGFR3 FGFR3 GNB3 GNB3 SYNGAP1 SYNGAP1 LOC115516057 LOC115516057 ENSLCNP00005006099 ENSLCNP00005006099 PLCG1 PLCG1 MAP2K2 MAP2K2 PLA2G4E PLA2G4E PLA2G4D PLA2G4D RGL2 RGL2 ENSLCNP00005005812 ENSLCNP00005005812 PLA2G4F PLA2G4F MAPK10 MAPK10 FGF17 FGF17 GNG11 GNG11 NFKB1 NFKB1 GNGT1 GNGT1 PDGFRA PDGFRA KIT KIT KDR KDR PAK5 PAK5 RAF1 RAF1 CALM2 CALM2 VEGFA VEGFA STK4 STK4 KITLG KITLG ENSLCNP00005003700 ENSLCNP00005003700 RASGRP3 RASGRP3 AKT1 AKT1 GNG7 GNG7 RAP1B RAP1B RASAL3 RASAL3 NTF3 NTF3 RASA1 RASA1 IKBKB IKBKB FGF6 FGF6 FGF23 FGF23 MAPK9 MAPK9 INSR INSR TBK1 TBK1 FLT4 FLT4 ZAP70 ZAP70 CALM1 CALM1 VEGFC VEGFC EGF EGF MAP2K1 MAP2K1 FGF1 FGF1 RASGRF2 RASGRF2 EFNA2 EFNA2 SOS1 SOS1 RASSF1 RASSF1 FGF18 FGF18 RASA3 RASA3 FLT1 FLT1 FLT3 FLT3 ENSLCNP00005000048 ENSLCNP00005000048 EPHA2 EPHA2 GRB2 GRB2 ENSLCNP00005034880 ENSLCNP00005034880 TEK TEK GNGT2 GNGT2 NGFR NGFR PRKCB PRKCB ABL1 ABL1 PLA2G4A PLA2G4A KSR2 KSR2 IKBKG IKBKG ABL2 ABL2 PLAAT3 PLAAT3 ENSLCNP00005032826 ENSLCNP00005032826 GNG8 GNG8 ENSLCNP00005032808 ENSLCNP00005032808 CALM3 CALM3 AKT3 AKT3 FLT3LG FLT3LG RASAL2 RASAL2 GNG3 GNG3 PAK4 PAK4 NGF NGF PLA2G1B PLA2G1B ERAS ERAS FGF16 FGF16 NTRK1 NTRK1 VEGFD VEGFD BDNF BDNF CSDE1 CSDE1 NTF4 NTF4 NRAS NRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK3Mitogen-activated protein kinase 3. (379 aa)
RAC1Rac family small GTPase 1. (211 aa)
GNB2G protein subunit beta 2. (340 aa)
RAC3Rac family small GTPase 3. (192 aa)
ELK1ETS transcription factor ELK1. (435 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1327 aa)
ANGPT4Angiopoietin 4. (499 aa)
RGL1Ral guanine nucleotide dissociation stimulator like 1. (807 aa)
RASGRP4RAS guanyl releasing protein 4. (671 aa)
SHC1SHC adaptor protein 1. (584 aa)
FGF21Fibroblast growth factor 21. (210 aa)
PAK3P21 (RAC1) activated kinase 3. (580 aa)
ENSLCNP00005028782annotation not available (85 aa)
PRKCAProtein kinase C alpha. (688 aa)
ADAM15ADAM metallopeptidase domain 15. (869 aa)
FASLGFas ligand. (280 aa)
CALML6Calmodulin like 6. (232 aa)
GNB1G protein subunit beta 1. (340 aa)
EFNA4Ephrin A4. (203 aa)
ENSLCNP00005027979annotation not available (191 aa)
EFNA3Ephrin A3. (237 aa)
EFNA1Ephrin A1. (205 aa)
GNG4G protein subunit gamma 4. (75 aa)
RASSF5Ras association domain family member 5. (450 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
BCL2L1BCL2 like 1. (233 aa)
ENSLCNP00005026793annotation not available (75 aa)
LATLinker for activation of T cells. (231 aa)
AKT2AKT serine/threonine kinase 2. (481 aa)
PRKCGProtein kinase C gamma. (697 aa)
MAPK8Mitogen-activated protein kinase 8. (384 aa)
ENSLCNP00005026019annotation not available (570 aa)
FOXO4Forkhead box O4. (509 aa)
RASA4BRAS p21 protein activator 4B. (817 aa)
ANGPT1Angiopoietin 1. (498 aa)
PLA2G12BPhospholipase A2 group XIIB. (195 aa)
PVALEFParvalbumin like EF-hand containing. (134 aa)
RASA2RAS p21 protein activator 2. (854 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta. (1070 aa)
GNG13G protein subunit gamma 13. (67 aa)
MRASMuscle RAS oncogene homolog. (254 aa)
PLA2G10Group 10 secretory phospholipase A2-like. (161 aa)
PLCG2Phospholipase C gamma 2. (1265 aa)
FGF3Fibroblast growth factor 3. (230 aa)
FGF4Fibroblast growth factor 4. (207 aa)
FGF19Fibroblast growth factor 19. (219 aa)
RRASRAS related. (286 aa)
PLA1AProtein ADP-ribosylarginine hydrolase. (694 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
RAB17RAB17, member RAS oncogene family. (233 aa)
ENSLCNP00005023008annotation not available (172 aa)
ENSLCNP00005023001annotation not available (152 aa)
TRBV18T cell receptor beta variable 18. (147 aa)
ENSLCNP00005022959annotation not available (164 aa)
TRBV13T cell receptor beta variable 13. (142 aa)
ENSLCNP00005022936annotation not available (160 aa)
ENSLCNP00005022927annotation not available (197 aa)
ENSLCNP00005022920annotation not available (247 aa)
ENSLCNP00005022908annotation not available (149 aa)
ENSLCNP00005022895annotation not available (142 aa)
HRASHRas proto-oncogene, GTPase. (195 aa)
CSF1Colony stimulating factor 1. (569 aa)
MAPK1Mitogen-activated protein kinase 1. (360 aa)
PLD2Phospholipase D2. (933 aa)
NF1Neurofibromin 1. (2851 aa)
KSR1Kinase suppressor of ras 1. (928 aa)
NTRK2Neurotrophic receptor tyrosine kinase 2. (827 aa)
PLA2G3Phospholipase A2 group III. (522 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (925 aa)
FGFR2Fibroblast growth factor receptor 2. (841 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
SHOC2SHOC2 leucine rich repeat scaffold protein. (582 aa)
LOC115526480Insulin. (156 aa)
INSInsulin. (170 aa)
RAB5CRAB5C, member RAS oncogene family. (216 aa)
CDC42Cell division cycle 42. (191 aa)
CEP152Centrosomal protein 152. (1712 aa)
SHC4SHC adaptor protein 4. (630 aa)
RALBP1ralA binding protein 1. (647 aa)
GALK2Galactokinase 2. (458 aa)
SHC3SHC adaptor protein 3. (587 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
RIN1Ras and Rab interactor 1. (819 aa)
PLA2G2CPhospholipase A2 group IIC. (155 aa)
PLA2G2FPhospholipase A2 group IIF. (221 aa)
PLA2G2DPhospholipase A2 group IID. (145 aa)
PLA2G5Phospholipase A2 group V. (138 aa)
FGF8Fibroblast growth factor 8. (244 aa)
PLA2G2EGroup IIE secretory phospholipase A2. (142 aa)
RAB5ARas-related protein Rab-5A. (215 aa)
RASGRP2RAS guanyl releasing protein 2. (626 aa)
ENSLCNP00005018044annotation not available (65 aa)
PAK2P21 (RAC1) activated kinase 2. (524 aa)
GNB5G protein subunit beta 5. (353 aa)
GNG10G protein subunit gamma 10. (68 aa)
HTR75-hydroxytryptamine receptor 7. (448 aa)
ENSLCNP00005017177annotation not available (76 aa)
PAK1P21 (RAC1) activated kinase 1. (544 aa)
PDGFDPlatelet derived growth factor D. (405 aa)
BADBCL2 associated agonist of cell death. (168 aa)
BRAPBRCA1 associated protein. (592 aa)
RRAS2RAS related 2. (204 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (147 aa)
VEGFBVascular endothelial growth factor B. (185 aa)
GNB4G protein subunit beta 4. (340 aa)
GAB2GRB2 associated binding protein 2. (640 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha. (1068 aa)
PTPN11Protein tyrosine phosphatase non-receptor type 11. (597 aa)
ETS2ETS proto-oncogene 2, transcription factor. (486 aa)
ENSLCNP00005015940annotation not available (58 aa)
ENSLCNP00005015924annotation not available (566 aa)
ANGPT2Angiopoietin 2. (482 aa)
GNG14G protein subunit gamma 14. (72 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
RAC2Rac family small GTPase 2. (192 aa)
LOC115519995Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
GNG12G protein subunit gamma 12. (72 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta. (1044 aa)
GNG2G protein subunit gamma 2. (102 aa)
RASGRF1Ras protein specific guanine nucleotide releasing factor 1. (1021 aa)
RAPGEF5Rap guanine nucleotide exchange factor 5. (723 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1485 aa)
RHOARas homolog family member A. (193 aa)
GNG5G protein subunit gamma 5. (121 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta. (397 aa)
TIAM1TIAM Rac1 associated GEF 1. (1488 aa)
PGFPlacental growth factor. (176 aa)
HGFHepatocyte growth factor. (728 aa)
RPS6KL1Ribosomal protein S6 kinase like 1. (673 aa)
ENSLCNP00005011486annotation not available (82 aa)
FGF10Fibroblast growth factor 10. (218 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
TGFATransforming growth factor alpha. (184 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
ARF6ADP ribosylation factor 6. (175 aa)
PDGFBPlatelet derived growth factor subunit B. (245 aa)
AFDNAfadin, adherens junction formation factor. (1813 aa)
FGFR4Fibroblast growth factor receptor 4. (801 aa)
EXOC2Exocyst complex component 2. (924 aa)
IGF1Insulin like growth factor 1. (195 aa)
PLA2G6Phospholipase A2 group VI. (840 aa)
ENSLCNP00005009418annotation not available (85 aa)
ENSLCNP00005009362annotation not available (210 aa)
ENSLCNP00005009348annotation not available (306 aa)
PDGFRBPlatelet derived growth factor receptor beta. (1102 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
RASGRP1RAS guanyl releasing protein 1. (797 aa)
PDGFCPlatelet derived growth factor C. (345 aa)
EFNA5Ephrin A5. (228 aa)
RELREL proto-oncogene, NF-kB subunit. (561 aa)
FGF5Fibroblast growth factor 5. (270 aa)
IGF1RInsulin like growth factor 1 receptor. (1367 aa)
RALARAS like proto-oncogene A. (206 aa)
CALML3Calmodulin-like protein 3. (149 aa)
CALML5Calmodulin-like. (149 aa)
EGFREpidermal growth factor receptor. (1194 aa)
PAK6P21 (RAC1) activated kinase 6. (681 aa)
RAB5BRAB5B, member RAS oncogene family. (215 aa)
FGF22Fibroblast growth factor 22. (170 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1408 aa)
FGF20Fibroblast growth factor 20. (211 aa)
CALML4Calmodulin like 4. (196 aa)
ENSLCNP00005006752annotation not available (582 aa)
FGFR1Fibroblast growth factor receptor 1. (852 aa)
FGFR3Fibroblast growth factor receptor 3. (861 aa)
GNB3G protein subunit beta 3. (340 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1331 aa)
LOC115516057Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7. (781 aa)
ENSLCNP00005006099annotation not available (139 aa)
PLCG1Phospholipase C gamma 1. (1290 aa)
MAP2K2Mitogen-activated protein kinase kinase 2. (426 aa)
PLA2G4EPhospholipase A2 group IVE. (861 aa)
PLA2G4DPhospholipase A2 group IVD. (814 aa)
RGL2Ral guanine nucleotide dissociation stimulator like 2. (862 aa)
ENSLCNP00005005812annotation not available (150 aa)
PLA2G4FPhospholipase A2 group IVF. (849 aa)
MAPK10Mitogen-activated protein kinase 10. (465 aa)
FGF17Fibroblast growth factor 17. (216 aa)
GNG11G protein subunit gamma 11. (73 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
GNGT1G protein subunit gamma transducin 1. (74 aa)
PDGFRAPlatelet derived growth factor receptor alpha. (1089 aa)
KITKIT proto-oncogene, receptor tyrosine kinase. (977 aa)
KDRKinase insert domain receptor. (1356 aa)
PAK5P21 (RAC1) activated kinase 5. (719 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CALM2Calmodulin 2. (154 aa)
VEGFAVascular endothelial growth factor A. (450 aa)
STK4Serine/threonine kinase 4. (487 aa)
KITLGKIT ligand. (182 aa)
ENSLCNP00005003700annotation not available (54 aa)
RASGRP3RAS guanyl releasing protein 3. (692 aa)
AKT1AKT serine/threonine kinase 1. (754 aa)
GNG7G protein subunit gamma 7. (68 aa)
RAP1BRAP1B, member of RAS oncogene family. (184 aa)
RASAL3RAS protein activator like 3. (1012 aa)
NTF3Neurotrophin 3. (277 aa)
RASA1RAS p21 protein activator 1. (1002 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (783 aa)
FGF6Fibroblast growth factor 6. (208 aa)
FGF23Fibroblast growth factor 23. (245 aa)
MAPK9Mitogen-activated protein kinase 9. (424 aa)
INSRInsulin receptor. (1381 aa)
TBK1TANK binding kinase 1. (729 aa)
FLT4Fms related tyrosine kinase 4. (1364 aa)
ZAP70Tyrosine-protein kinase ZAP-70. (619 aa)
CALM1Calmodulin 3. (150 aa)
VEGFCVascular endothelial growth factor C. (423 aa)
EGFEpidermal growth factor. (1213 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
FGF1Fibroblast growth factor 1. (170 aa)
RASGRF2Ras protein specific guanine nucleotide releasing factor 2. (1239 aa)
EFNA2Ephrin A2. (214 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
RASSF1Ras association domain family member 1. (344 aa)
FGF18Fibroblast growth factor 18. (207 aa)
RASA3RAS p21 protein activator 3. (834 aa)
FLT1Fms related tyrosine kinase 1. (1338 aa)
FLT3Fms related tyrosine kinase 3. (994 aa)
ENSLCNP00005000048annotation not available (164 aa)
EPHA2EPH receptor A2. (1008 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ENSLCNP00005034880annotation not available (920 aa)
TEKTEK receptor tyrosine kinase. (738 aa)
GNGT2G protein subunit gamma transducin 2. (118 aa)
NGFRNerve growth factor receptor. (430 aa)
PRKCBProtein kinase C beta. (673 aa)
ABL1ABL proto-oncogene 1, non-receptor tyrosine kinase. (1150 aa)
PLA2G4APhospholipase A2 group IVA. (749 aa)
KSR2Kinase suppressor of ras 2. (949 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
ABL2ABL proto-oncogene 2, non-receptor tyrosine kinase. (1182 aa)
PLAAT3Phospholipase A and acyltransferase 3. (234 aa)
ENSLCNP00005032826annotation not available (156 aa)
GNG8G protein subunit gamma 8. (123 aa)
ENSLCNP00005032808annotation not available (191 aa)
CALM3Calmodulin 3. (149 aa)
AKT3AKT serine/threonine kinase 3. (479 aa)
FLT3LGFms related tyrosine kinase 3 ligand. (238 aa)
RASAL2RAS protein activator like 2. (1433 aa)
GNG3G protein subunit gamma 3. (75 aa)
PAK4P21 (RAC1) activated kinase 4. (592 aa)
NGFNerve growth factor. (294 aa)
PLA2G1BPhospholipase A2 group IB. (148 aa)
ERASES cell expressed Ras. (233 aa)
FGF16Fibroblast growth factor 16. (207 aa)
NTRK1Neurotrophic receptor tyrosine kinase 1. (785 aa)
VEGFDVascular endothelial growth factor D. (354 aa)
BDNFBrain derived neurotrophic factor. (255 aa)
CSDE1Cold shock domain containing E1. (844 aa)
NTF4Neurotrophin 4. (210 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
Your Current Organism:
Lynx canadensis
NCBI taxonomy Id: 61383
Other names: Canada lynx, Felis canadensis, L. canadensis
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