STRINGSTRING
ERAS ERAS SOS1 SOS1 MAP2K1 MAP2K1 IKBKB IKBKB AKT1 AKT1 RASGRP3 RASGRP3 RAF1 RAF1 PPP3CC PPP3CC NFKB1 NFKB1 NFKBIE NFKBIE PPP3CA PPP3CA DAPP1 DAPP1 MAP2K2 MAP2K2 ENSLCNP00005006164 ENSLCNP00005006164 IGHM IGHM PTPN6 PTPN6 PIK3R2 PIK3R2 JUN JUN PPP3R1 PPP3R1 NFKBIA NFKBIA SOS2 SOS2 NFATC2 NFATC2 FOS FOS INPPL1 INPPL1 PIK3CD PIK3CD BCL10 BCL10 BLNK BLNK LOC115519995 LOC115519995 RAC2 RAC2 PIK3R1 PIK3R1 PIK3CA PIK3CA INPP5D INPP5D MALT1 MALT1 ENSLCNP00005018662 ENSLCNP00005018662 CHUK CHUK SYK SYK VAV3 VAV3 RELA RELA PIK3AP1 PIK3AP1 NFATC1 NFATC1 LOC115525097 LOC115525097 MAPK1 MAPK1 HRAS HRAS GSK3B GSK3B KRAS KRAS PLCG2 PLCG2 PIK3CB PIK3CB AKT2 AKT2 CR2 CR2 ENSLCNP00005027352 ENSLCNP00005027352 CD19 CD19 ENSLCNP00005027560 ENSLCNP00005027560 NFATC3 NFATC3 ENSLCNP00005027962 ENSLCNP00005027962 BTK BTK ENSLCNP00005028746 ENSLCNP00005028746 RAC3 RAC3 CD22 CD22 RAC1 RAC1 MAPK3 MAPK3 NRAS NRAS CSDE1 CSDE1 NFKBIB NFKBIB LOC115505601 LOC115505601 CD79A CD79A LYN LYN ENSLCNP00005031923 ENSLCNP00005031923 ENSLCNP00005032151 ENSLCNP00005032151 ENSLCNP00005032175 ENSLCNP00005032175 AKT3 AKT3 IKBKG IKBKG CARD11 CARD11 CD79B CD79B VAV1 VAV1 VAV2 VAV2 PRKCB PRKCB GRB2 GRB2 PPP3CB PPP3CB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERASES cell expressed Ras. (233 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (783 aa)
AKT1AKT serine/threonine kinase 1. (754 aa)
RASGRP3RAS guanyl releasing protein 3. (692 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
PPP3CCProtein phosphatase 3 catalytic subunit gamma. (530 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
NFKBIENFKB inhibitor epsilon. (362 aa)
PPP3CAProtein phosphatase 3 catalytic subunit alpha. (521 aa)
DAPP1Dual adaptor of phosphotyrosine and 3-phosphoinositides 1. (280 aa)
MAP2K2Mitogen-activated protein kinase kinase 2. (426 aa)
ENSLCNP00005006164annotation not available (454 aa)
IGHMImmunoglobulin heavy constant mu. (558 aa)
PTPN6Protein tyrosine phosphatase non-receptor type 6. (597 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit. (334 aa)
PPP3R1Protein phosphatase 3 regulatory subunit B, alpha. (170 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
NFATC2Nuclear factor of activated T cells 2. (695 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1265 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta. (1044 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
BLNKB cell linker. (475 aa)
LOC115519995Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
RAC2Rac family small GTPase 2. (192 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha. (1068 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1182 aa)
MALT1MALT1 paracaspase. (826 aa)
ENSLCNP00005018662annotation not available (99 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
PIK3AP1Phosphoinositide-3-kinase adaptor protein 1. (805 aa)
NFATC1Nuclear factor of activated T cells 1. (649 aa)
LOC115525097Interferon-induced transmembrane protein 1-like. (125 aa)
MAPK1Mitogen-activated protein kinase 1. (360 aa)
HRASHRas proto-oncogene, GTPase. (195 aa)
GSK3BGlycogen synthase kinase 3 beta. (433 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PLCG2Phospholipase C gamma 2. (1265 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta. (1070 aa)
AKT2AKT serine/threonine kinase 2. (481 aa)
CR2Complement C3d receptor 2. (1097 aa)
ENSLCNP00005027352annotation not available (452 aa)
CD19CD19 molecule. (558 aa)
ENSLCNP00005027560annotation not available (634 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
ENSLCNP00005027962annotation not available (665 aa)
BTKBruton tyrosine kinase. (659 aa)
ENSLCNP00005028746annotation not available (663 aa)
RAC3Rac family small GTPase 3. (192 aa)
CD22CD22 molecule. (846 aa)
RAC1Rac family small GTPase 1. (211 aa)
MAPK3Mitogen-activated protein kinase 3. (379 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CSDE1Cold shock domain containing E1. (844 aa)
NFKBIBNFKB inhibitor beta. (354 aa)
LOC115505601Low affinity immunoglobulin gamma Fc region receptor II-like. (270 aa)
CD79ACD79a molecule. (236 aa)
LYNLYN proto-oncogene, Src family tyrosine kinase. (660 aa)
ENSLCNP00005031923annotation not available (121 aa)
ENSLCNP00005032151annotation not available (190 aa)
ENSLCNP00005032175annotation not available (134 aa)
AKT3AKT serine/threonine kinase 3. (479 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
CARD11Caspase recruitment domain family member 11. (1336 aa)
CD79BCD79b molecule. (224 aa)
VAV1Vav guanine nucleotide exchange factor 1. (768 aa)
VAV2Vav guanine nucleotide exchange factor 2. (756 aa)
PRKCBProtein kinase C beta. (673 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PPP3CBProtein phosphatase 3 catalytic subunit beta. (537 aa)
Your Current Organism:
Lynx canadensis
NCBI taxonomy Id: 61383
Other names: Canada lynx, Felis canadensis, L. canadensis
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