(38 nodes) Mixed, incl. GMP biosynthetic process, and Metal-dependent hydrolase, composite domain superfamily network (Rhinopithecus bieti)

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Predicted Interactions

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Your Input:
	IMPDH	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (494 aa)
	DSTYK	Dual serine/threonine and tyrosine protein kinase. (931 aa)
	PRTFDC1	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (225 aa)
	PAICS	AIRC domain-containing protein. (450 aa)
	CAD	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2225 aa)
	CYB5RL	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (315 aa)
	CYB5R4	Cytochrome b5 reductase 4. (538 aa)
	SLC23A2	Solute carrier family 23 member 2. (650 aa)
	GDA	Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (420 aa)
	DPYSL4	Dihydropyrimidinase like 4. (675 aa)
	GPR143	G protein-coupled receptor 143. (407 aa)
	DPYSL5	Dihydropyrimidinase like 5. (565 aa)
	ADK	PfkB domain-containing protein. (166 aa)
	GOLT1A	Golgi transport 1A. (132 aa)
	ENKUR	Enkurin, TRPC channel interacting protein. (230 aa)
	ADSL	Adenylosuccinate lyase. (378 aa)
	DHODH	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (367 aa)
	FES	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
	GOLT1B	Golgi transport 1B. (138 aa)
	CYB5R2	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (276 aa)
	DPYD	Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (996 aa)
	DPYS	Dihydropyrimidinase. (519 aa)
	UPB1	Beta-ureidopropionase 1. (384 aa)
	DPYSL2	Dihydropyrimidinase like 2. (677 aa)
	PPAT	Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (517 aa)
	ENSRBIP00000034365	PNP_UDP_1 domain-containing protein. (198 aa)
	OXNAD1	Oxidoreductase NAD binding domain containing 1. (312 aa)
	LOC108520458	Uncharacterized protein. (150 aa)
	CRMP1	Collapsin response mediator protein 1. (668 aa)
	IMPDH-2	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (628 aa)
	AMPD1	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (738 aa)
	ENSRBIP00000038323	CBS domain-containing protein. (456 aa)
	ADA2	Adenosine deaminase 2. (472 aa)
	ENSRBIP00000039782	Uncharacterized protein. (486 aa)
	DPYSL3	Dihydropyrimidinase like 3. (682 aa)
	SLC23A1	Solute carrier family 23 member 1. (598 aa)
	UMPS	Uridine monophosphate synthetase. (480 aa)
	ENSRBIP00000042716	A_deaminase domain-containing protein. (344 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADA2	ADK	ENSRBIP00000038552	ENSRBIP00000015771	Adenosine deaminase 2.	PfkB domain-containing protein.	0.611
ADA2	AMPD1	ENSRBIP00000038552	ENSRBIP00000038315	Adenosine deaminase 2.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.418
ADA2	ENKUR	ENSRBIP00000038552	ENSRBIP00000018881	Adenosine deaminase 2.	Enkurin, TRPC channel interacting protein.	0.532
ADA2	ENSRBIP00000034365	ENSRBIP00000038552	ENSRBIP00000034365	Adenosine deaminase 2.	PNP_UDP_1 domain-containing protein.	0.500
ADA2	ENSRBIP00000042716	ENSRBIP00000038552	ENSRBIP00000042716	Adenosine deaminase 2.	A_deaminase domain-containing protein.	0.455
ADA2	PRTFDC1	ENSRBIP00000038552	ENSRBIP00000004224	Adenosine deaminase 2.	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.553
ADK	ADA2	ENSRBIP00000015771	ENSRBIP00000038552	PfkB domain-containing protein.	Adenosine deaminase 2.	0.611
ADK	ADSL	ENSRBIP00000015771	ENSRBIP00000019131	PfkB domain-containing protein.	Adenylosuccinate lyase.	0.498
ADK	AMPD1	ENSRBIP00000015771	ENSRBIP00000038315	PfkB domain-containing protein.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.497
ADK	ENSRBIP00000034365	ENSRBIP00000015771	ENSRBIP00000034365	PfkB domain-containing protein.	PNP_UDP_1 domain-containing protein.	0.508
ADK	ENSRBIP00000042716	ENSRBIP00000015771	ENSRBIP00000042716	PfkB domain-containing protein.	A_deaminase domain-containing protein.	0.606
ADK	LOC108520458	ENSRBIP00000015771	ENSRBIP00000035226	PfkB domain-containing protein.	Uncharacterized protein.	0.498
ADK	UMPS	ENSRBIP00000015771	ENSRBIP00000041690	PfkB domain-containing protein.	Uridine monophosphate synthetase.	0.424
ADSL	ADK	ENSRBIP00000019131	ENSRBIP00000015771	Adenylosuccinate lyase.	PfkB domain-containing protein.	0.498
ADSL	CAD	ENSRBIP00000019131	ENSRBIP00000005077	Adenylosuccinate lyase.	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase.	0.427
ADSL	DHODH	ENSRBIP00000019131	ENSRBIP00000019320	Adenylosuccinate lyase.	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.	0.498
ADSL	DPYD	ENSRBIP00000019131	ENSRBIP00000022456	Adenylosuccinate lyase.	Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family.	0.498
ADSL	ENKUR	ENSRBIP00000019131	ENSRBIP00000018881	Adenylosuccinate lyase.	Enkurin, TRPC channel interacting protein.	0.800
ADSL	ENSRBIP00000038323	ENSRBIP00000019131	ENSRBIP00000038323	Adenylosuccinate lyase.	CBS domain-containing protein.	0.539
ADSL	ENSRBIP00000039782	ENSRBIP00000019131	ENSRBIP00000039782	Adenylosuccinate lyase.	Uncharacterized protein.	0.539