STRINGSTRING
FGF10 FGF10 FGF4 FGF4 KLB KLB FGF1 FGF1 FGF3 FGF3 FGFR2 FGFR2 FGFRL1 FGFRL1 FGF19 FGF19 FGFR1 FGFR1 LOC108512216 LOC108512216 FGFR4 FGFR4 FGF7 FGF7 FGF23 FGF23 FGF8 FGF8 FRS2 FRS2 FGF9 FGF9 FGF2 FGF2 FGF17 FGF17 FGFR3 FGFR3 KL KL FGF18 FGF18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
KLBKlotho beta. (947 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
FGFRL1Fibroblast growth factor receptor like 1. (487 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGFR1Fibroblast growth factor receptor. (829 aa)
LOC108512216Uncharacterized protein. (377 aa)
FGFR4Fibroblast growth factor receptor. (749 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (263 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGFR3Fibroblast growth factor receptor. (783 aa)
KLKlotho. (951 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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