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| | CDCA7L | Cell division cycle associated 7 like. (455 aa) |
| | BRCA2 | Uncharacterized protein. (386 aa) |
| | ENSRBIP00000000510 | Uncharacterized protein. (105 aa) |
| | FANCI | FA complementation group I. (1288 aa) |
| | ENSRBIP00000000804 | RPA_C domain-containing protein. (235 aa) |
| | MSH3 | MutS homolog 3. (1195 aa) |
| | RAD51D | RAD51 paralog D. (347 aa) |
| | CETN2 | Centrin 2. (172 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (991 aa) |
| | LOC108532799 | FANCA_interact domain-containing protein. (135 aa) |
| | GINS1 | GINS complex subunit 1. (196 aa) |
| | FANCM | FA complementation group M. (2047 aa) |
| | ORC6 | Origin recognition complex subunit 6. (252 aa) |
| | TIMELESS | Timeless circadian regulator. (1208 aa) |
| | MSH4 | MutS homolog 4. (935 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | ENSRBIP00000003378 | Metallophos domain-containing protein. (233 aa) |
| | MCM8 | MCM domain-containing protein; Belongs to the MCM family. (880 aa) |
| | CHTF18 | Chromosome transmission fidelity factor 18. (999 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1305 aa) |
| | FSBP | Uncharacterized protein. (908 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (858 aa) |
| | NUTF2 | NTF2 domain-containing protein. (127 aa) |
| | CHTF8 | Chromosome transmission fidelity factor 8. (121 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1226 aa) |
| | LOC108521487 | BIVM-ERCC5 readthrough. (1654 aa) |
| | FANCA | FA complementation group A. (1375 aa) |
| | FANCD2 | Uncharacterized protein. (1422 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (218 aa) |
| | RMI1 | RecQ mediated genome instability 1. (625 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | MLH1 | MutL homolog 1. (754 aa) |
| | MSH5 | DNA_MISMATCH_REPAIR_2 domain-containing protein. (778 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (419 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1140 aa) |
| | XPC | XPC complex subunit, DNA damage recognition and repair factor. (939 aa) |
| | RBPMS2 | Uncharacterized protein. (98 aa) |
| | TM4SF19 | Uncharacterized protein. (295 aa) |
| | ENSRBIP00000008844 | NTF2 domain-containing protein. (108 aa) |
| | POLH | DNA polymerase eta. (697 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1149 aa) |
| | ENSRBIP00000009490 | Uncharacterized protein. (81 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1718 aa) |
| | HUS1B | Checkpoint protein; Belongs to the HUS1 family. (277 aa) |
| | ENSRBIP00000010861 | NTF2 domain-containing protein. (127 aa) |
| | BLM | BLM RecQ like helicase. (1396 aa) |
| | ORC3 | ORC_WH_C domain-containing protein. (316 aa) |
| | DBF4 | DBF4 zinc finger. (648 aa) |
| | MEIOB | Meiosis specific with OB-fold. (449 aa) |
| | WRNIP1 | WRN helicase interacting protein 1. (663 aa) |
| | RHNO1 | Uncharacterized protein. (240 aa) |
| | CLSPN | Claspin. (1301 aa) |
| | GMNN | Geminin DNA replication inhibitor. (209 aa) |
| | ENSRBIP00000013617 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (245 aa) |
| | ENSRBIP00000013688 | Uncharacterized protein. (232 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (621 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa) |
| | TDRD3 | Tudor domain containing 3. (749 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (932 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (347 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (907 aa) |
| | REV1 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1241 aa) |
| | MLH3 | MutL homolog 3. (1449 aa) |
| | SPO11 | SPO11 initiator of meiotic double stranded breaks. (407 aa) |
| | RAD51C | RAD51 paralog C. (376 aa) |
| | WRN | WRN RecQ like helicase. (1394 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (390 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (377 aa) |
| | LOC108537870 | Uncharacterized protein. (322 aa) |
| | DCLRE1B | DNA cross-link repair 1B. (532 aa) |
| | POLD1 | DNA polymerase. (1124 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | DCLRE1A | DNA cross-link repair 1A. (1040 aa) |
| | WDR48 | WD repeat domain 48. (644 aa) |
| | ENSRBIP00000017801 | Uncharacterized protein. (86 aa) |
| | POLI | DNA polymerase iota. (738 aa) |
| | ORC2 | Origin recognition complex subunit 2. (575 aa) |
| | LOC108523819 | Piezo_RRas_bdg domain-containing protein. (489 aa) |
| | FANCG | FA complementation group G. (622 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (571 aa) |
| | RECQL4 | RecQ like helicase 4. (1197 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1281 aa) |
| | MCPH1 | Microcephalin 1. (749 aa) |
| | ENSRBIP00000019958 | Uncharacterized protein. (231 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1017 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (908 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3026 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | DSCC1 | DNA replication and sister chromatid cohesion 1. (416 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (907 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (667 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2253 aa) |
| | TOP3B | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa) |
| | LOC108522364 | Uncharacterized protein. (389 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (288 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa) |
| | PMS1 | PMS1 homolog 1, mismatch repair system component. (933 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1484 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (670 aa) |
| | PSMC3IP | PSMC3 interacting protein. (217 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (404 aa) |
| | FANCL | FA complementation group L. (383 aa) |
| | RAD51B | RAD51 paralog B. (426 aa) |
| | RAD1 | Uncharacterized protein. (280 aa) |
| | RPA2 | Replication protein A2. (273 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (828 aa) |
| | TMEM208 | Transmembrane protein 208. (173 aa) |
| | POLD4 | Uncharacterized protein. (107 aa) |
| | MND1 | Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (190 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (117 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | EXO1 | Exonuclease 1. (827 aa) |
| | WDHD1 | WD repeat and HMG-box DNA binding protein 1. (1123 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (752 aa) |
| | XPA | XPA, DNA damage recognition and repair factor. (303 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (504 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (492 aa) |
| | RFWD3 | Ring finger and WD repeat domain 3. (773 aa) |
| | POLK | DNA polymerase kappa. (866 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2578 aa) |
| | RFC4 | Replication factor C subunit 4. (362 aa) |
| | UBE2T | Ubiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (240 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | RMI2 | RecQ mediated genome instability 2. (150 aa) |
| | ORC5 | Origin recognition complex subunit 5. (424 aa) |
| | FBH1 | F-box DNA helicase 1. (1079 aa) |
| | CDC45 | Cell division cycle 45. (552 aa) |
| | FAAP100 | FA core complex associated protein 100. (881 aa) |
| | RFC5 | Replication factor C subunit 5. (309 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1343 aa) |
| | PRIMPOL | Primase and DNA directed polymerase. (551 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (435 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (281 aa) |
| | PMS2 | PMS1 homolog 2, mismatch repair system component. (572 aa) |
| | PRIM1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (337 aa) |
| | GINS3 | GINS complex subunit 3. (255 aa) |
| | ZRANB3 | Zinc finger RANBP2-type containing 3. (998 aa) |
| | FANCB | FA complementation group B. (516 aa) |
| | SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (959 aa) |
| | PRIM2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (486 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1814 aa) |
| | MCM10 | Minichromosome maintenance 10 replication initiation factor. (904 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | RFC1 | Replication factor C subunit 1. (1114 aa) |
| | CDC7 | Cell division cycle 7. (574 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (551 aa) |
| | ENSRBIP00000034615 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (275 aa) |
| | DDX11 | DEAD/H-box helicase 11. (906 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3106 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1047 aa) |
| | ENSRBIP00000035711 | RAD51_interact domain-containing protein. (282 aa) |
| | USP1 | Ubiquitin specific peptidase 1; Belongs to the peptidase C19 family. (773 aa) |
| | SH2D2A | SH2 domain containing 2A. (412 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (147 aa) |
| | FAAP24 | FA core complex associated protein 24. (215 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1527 aa) |
| | MCMBP | Minichromosome maintenance complex binding protein. (639 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | RAD54L | RAD54 like. (747 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (676 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (771 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (376 aa) |
| | DBF4B | DBF4 zinc finger B. (520 aa) |
| | LIG1 | DNA ligase. (928 aa) |
| | ENSRBIP00000040579 | Sld5 domain-containing protein. (151 aa) |
| | SFR1 | SWI5 dependent homologous recombination repair protein 1. (245 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (289 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1818 aa) |
| | ATRIP | ATR interacting protein. (790 aa) |
| | FANCE | FA complementation group E. (536 aa) |
| | POLA2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1050 aa) |
| | POLD3 | Uncharacterized protein. (454 aa) |
| | LOC108532656 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (172 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (898 aa) |
| | ENSRBIP00000043218 | Uncharacterized protein. (153 aa) |
| | FANCC | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (558 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (512 aa) |
| | PIEZO1 | Piezo-type mechanosensitive ion channel component. (2423 aa) |
