8 items (Rhinopithecus bieti) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	RMI1	RecQ mediated genome instability 1. (625 aa)
	BLM	BLM RecQ like helicase. (1396 aa)
	TOP3A	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa)
	WRN	WRN RecQ like helicase. (1394 aa)
	RPA2	Replication protein A2. (273 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	RMI2	RecQ mediated genome instability 2. (150 aa)
	RPA3	Replication protein A3. (121 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BLM	RMI1	ENSRBIP00000011579	ENSRBIP00000007133	BLM RecQ like helicase.	RecQ mediated genome instability 1.	0.998
BLM	RMI2	ENSRBIP00000011579	ENSRBIP00000027836	BLM RecQ like helicase.	RecQ mediated genome instability 2.	0.991
BLM	RPA1	ENSRBIP00000011579	ENSRBIP00000025409	BLM RecQ like helicase.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.998
BLM	RPA2	ENSRBIP00000011579	ENSRBIP00000024682	BLM RecQ like helicase.	Replication protein A2.	0.988
BLM	RPA3	ENSRBIP00000011579	ENSRBIP00000033251	BLM RecQ like helicase.	Replication protein A3.	0.997
BLM	TOP3A	ENSRBIP00000011579	ENSRBIP00000014152	BLM RecQ like helicase.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.999
BLM	WRN	ENSRBIP00000011579	ENSRBIP00000015492	BLM RecQ like helicase.	WRN RecQ like helicase.	0.686
RMI1	BLM	ENSRBIP00000007133	ENSRBIP00000011579	RecQ mediated genome instability 1.	BLM RecQ like helicase.	0.998
RMI1	RMI2	ENSRBIP00000007133	ENSRBIP00000027836	RecQ mediated genome instability 1.	RecQ mediated genome instability 2.	0.999
RMI1	RPA1	ENSRBIP00000007133	ENSRBIP00000025409	RecQ mediated genome instability 1.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.998
RMI1	RPA2	ENSRBIP00000007133	ENSRBIP00000024682	RecQ mediated genome instability 1.	Replication protein A2.	0.986
RMI1	RPA3	ENSRBIP00000007133	ENSRBIP00000033251	RecQ mediated genome instability 1.	Replication protein A3.	0.997
RMI1	TOP3A	ENSRBIP00000007133	ENSRBIP00000014152	RecQ mediated genome instability 1.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.999
RMI1	WRN	ENSRBIP00000007133	ENSRBIP00000015492	RecQ mediated genome instability 1.	WRN RecQ like helicase.	0.991
RMI2	BLM	ENSRBIP00000027836	ENSRBIP00000011579	RecQ mediated genome instability 2.	BLM RecQ like helicase.	0.991
RMI2	RMI1	ENSRBIP00000027836	ENSRBIP00000007133	RecQ mediated genome instability 2.	RecQ mediated genome instability 1.	0.999
RMI2	RPA1	ENSRBIP00000027836	ENSRBIP00000025409	RecQ mediated genome instability 2.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.963
RMI2	RPA2	ENSRBIP00000027836	ENSRBIP00000024682	RecQ mediated genome instability 2.	Replication protein A2.	0.937
RMI2	RPA3	ENSRBIP00000027836	ENSRBIP00000033251	RecQ mediated genome instability 2.	Replication protein A3.	0.961
RMI2	TOP3A	ENSRBIP00000027836	ENSRBIP00000014152	RecQ mediated genome instability 2.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.993