STRINGSTRING
DCLRE1B DCLRE1B PARP1 PARP1 INO80D INO80D ZSCAN4 ZSCAN4 ENSRBIP00000041364 ENSRBIP00000041364 ERCC1 ERCC1 TERF1 TERF1 INO80B INO80B FBXO4 FBXO4 ACD ACD CTC1 CTC1 LTO1 LTO1 ENSRBIP00000037689 ENSRBIP00000037689 TINF2 TINF2 ENSRBIP00000036862 ENSRBIP00000036862 PINX1 PINX1 DNA2 DNA2 ENSRBIP00000034985 ENSRBIP00000034985 CCNE2 CCNE2 PARP3 PARP3 RFC1 RFC1 RPA3 RPA3 POT1 POT1 SLX4 SLX4 SMARCAL1 SMARCAL1 STN1 STN1 XRCC6 XRCC6 RAD51 RAD51 ZNF827 ZNF827 SMC5 SMC5 ZBTB48 ZBTB48 TELO2 TELO2 TERF2 TERF2 RTEL1 RTEL1 APEX1 APEX1 TFPT TFPT ACTR8 ACTR8 HUS1 HUS1 ATR ATR INO80E INO80E NBN NBN ENSRBIP00000025761 ENSRBIP00000025761 EXO1 EXO1 RPA1 RPA1 ACTL6A ACTL6A SP100 SP100 WRAP53 WRAP53 XRCC4 XRCC4 RUVBL2 RUVBL2 SLX1A SLX1A ATM ATM RAD50 RAD50 RECQL4 RECQL4 RUVBL1 RUVBL1 XRCC5 XRCC5 TERF2IP TERF2IP PIF1 PIF1 DCLRE1A DCLRE1A CCNE1 CCNE1 TERT TERT SMC6 SMC6 INO80 INO80 WRN WRN RAD51C RAD51C ERCC4 ERCC4 XRCC3 XRCC3 TEP1 TEP1 PRKDC PRKDC ENSRBIP00000013617 ENSRBIP00000013617 BLM BLM ENSRBIP00000011182 ENSRBIP00000011182 ENSRBIP00000010478 ENSRBIP00000010478 HUS1B HUS1B DKC1 DKC1 MCRS1 MCRS1 NFRKB NFRKB PCNA PCNA MAD2L2 MAD2L2 ENSRBIP00000005985 ENSRBIP00000005985 SHLD1 SHLD1 LOC108517067 LOC108517067 ZNF365 ZNF365 GAR1 GAR1 TPRKB TPRKB NHP2 NHP2 UPF1 UPF1 ENSRBIP00000001755 ENSRBIP00000001755 UCHL5 UCHL5 RIF1 RIF1 NSMCE2 NSMCE2 BRCA2 BRCA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DCLRE1BDNA cross-link repair 1B. (532 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
INO80DINO80 complex subunit D. (1028 aa)
ZSCAN4Zinc finger and SCAN domain containing 4. (431 aa)
ENSRBIP00000041364Ku domain-containing protein. (498 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (289 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (406 aa)
INO80BPAPA-1 domain-containing protein. (373 aa)
FBXO4F-box protein 4. (375 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (528 aa)
CTC1CST telomere replication complex component 1. (1217 aa)
LTO1LTO1 maturation factor of ABCE1. (216 aa)
ENSRBIP00000037689H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (191 aa)
TINF2TINF2_N domain-containing protein. (451 aa)
ENSRBIP00000036862Ku domain-containing protein. (567 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (327 aa)
DNA2DNA replication helicase/nuclease 2. (1047 aa)
ENSRBIP00000034985TINF2_N domain-containing protein. (339 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (403 aa)
PARP3Poly [ADP-ribose] polymerase. (531 aa)
RFC1Replication factor C subunit 1. (1114 aa)
RPA3Replication protein A3. (121 aa)
POT1Protection of telomeres 1. (633 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1814 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (959 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
XRCC6X-ray repair cross complementing 6. (568 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (337 aa)
ZNF827Zinc finger protein 827. (1071 aa)
SMC5Structural maintenance of chromosomes 5. (1054 aa)
ZBTB48Zinc finger and BTB domain containing 48. (813 aa)
TELO2Telomere maintenance 2. (836 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (421 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1343 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (322 aa)
TFPTTCF3 fusion partner. (253 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2578 aa)
INO80EINO80 complex subunit E. (244 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (752 aa)
ENSRBIP00000025761TINF2_N domain-containing protein. (517 aa)
EXO1Exonuclease 1. (827 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
ACTL6AActin like 6A; Belongs to the actin family. (429 aa)
SP100SP100 nuclear antigen. (823 aa)
WRAP53WD repeat containing antisense to TP53. (549 aa)
XRCC4X-ray repair cross complementing 4. (231 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3026 aa)
RAD50Zinc-hook domain-containing protein. (1281 aa)
RECQL4RecQ like helicase 4. (1197 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
XRCC5X-ray repair cross complementing 5. (805 aa)
TERF2IPTERF2 interacting protein. (400 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (641 aa)
DCLRE1ADNA cross-link repair 1A. (1040 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (451 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1167 aa)
SMC6Structural maintenance of chromosomes 6. (1040 aa)
INO80INO80 complex ATPase subunit. (1555 aa)
WRNWRN RecQ like helicase. (1394 aa)
RAD51CRAD51 paralog C. (376 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (907 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (347 aa)
TEP1Telomerase associated protein 1. (2633 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa)
ENSRBIP00000013617Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (245 aa)
BLMBLM RecQ like helicase. (1396 aa)
ENSRBIP00000011182Ku domain-containing protein. (328 aa)
ENSRBIP00000010478SP-RING-type domain-containing protein. (216 aa)
HUS1BCheckpoint protein; Belongs to the HUS1 family. (277 aa)
DKC1Dyskerin pseudouridine synthase 1. (597 aa)
MCRS1Microspherule protein 1. (475 aa)
NFRKBNuclear factor related to kappaB binding protein. (1311 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (218 aa)
ENSRBIP00000005985Uncharacterized protein. (64 aa)
SHLD1Shieldin complex subunit 1. (254 aa)
LOC108517067Uncharacterized protein. (64 aa)
ZNF365Zinc finger protein 365. (411 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (217 aa)
TPRKBTP53RK binding protein; Belongs to the CGI121/TPRKB family. (175 aa)
NHP2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa)
UPF1UPF1 RNA helicase and ATPase. (1068 aa)
ENSRBIP00000001755Uncharacterized protein. (218 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (369 aa)
RIF1Replication timing regulatory factor 1. (2444 aa)
NSMCE2SP-RING-type domain-containing protein. (246 aa)
BRCA2Uncharacterized protein. (386 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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