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| | TERF2IP | TERF2 interacting protein. (400 aa) |
| | PML | Promyelocytic leukemia. (932 aa) |
| | ENSRBIP00000035176 | Uncharacterized protein. (360 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1047 aa) |
| | ENSRBIP00000034985 | TINF2_N domain-containing protein. (339 aa) |
| | SETX | Senataxin. (2655 aa) |
| | POT1 | Protection of telomeres 1. (633 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1814 aa) |
| | ENSRBIP00000032469 | Uncharacterized protein. (153 aa) |
| | KDM1A | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (883 aa) |
| | STN1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (568 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (337 aa) |
| | ENSRBIP00000031680 | WD_REPEATS_REGION domain-containing protein. (408 aa) |
| | ZNF827 | Zinc finger protein 827. (1071 aa) |
| | SMC5 | Structural maintenance of chromosomes 5. (1054 aa) |
| | TNKS | Poly [ADP-ribose] polymerase. (1276 aa) |
| | ZBTB48 | Zinc finger and BTB domain containing 48. (813 aa) |
| | NABP2 | Nucleic acid binding protein 2. (211 aa) |
| | MAJIN | Membrane anchored junction protein. (254 aa) |
| | TERB1 | Telomere repeat binding bouquet formation protein 1. (674 aa) |
| | TELO2 | Telomere maintenance 2. (836 aa) |
| | TERF2 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (421 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (435 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | MTA2 | Metastasis associated 1 family member 2. (673 aa) |
| | ENSRBIP00000028523 | ChSh domain-containing protein. (217 aa) |
| | ORC5 | Origin recognition complex subunit 5. (424 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | MACROH2A2 | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa) |
| | LRWD1 | Leucine rich repeats and WD repeat domain containing 1. (681 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (752 aa) |
| | BRCA2 | Uncharacterized protein. (386 aa) |
| | NSMCE2 | SP-RING-type domain-containing protein. (246 aa) |
| | H2AC1 | Histone H2A; Belongs to the histone H2A family. (131 aa) |
| | TNKS2 | Poly [ADP-ribose] polymerase. (1165 aa) |
| | RBBP4 | WD_REPEATS_REGION domain-containing protein. (419 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2444 aa) |
| | ENSRBIP00000001755 | Uncharacterized protein. (218 aa) |
| | TEN1 | Uncharacterized protein. (123 aa) |
| | ENSRBIP00000001977 | HMG box domain-containing protein. (580 aa) |
| | SUN2 | Sad1 and UNC84 domain containing 2. (721 aa) |
| | UPF1 | UPF1 RNA helicase and ATPase. (1068 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | ENSRBIP00000003378 | Metallophos domain-containing protein. (233 aa) |
| | NABP1 | Nucleic acid binding protein 1. (204 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (468 aa) |
| | GAR1 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (217 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (858 aa) |
| | SMG6 | SMG6 nonsense mediated mRNA decay factor. (1419 aa) |
| | LOC108525285 | Uncharacterized protein. (274 aa) |
| | CBX1 | Chromo domain-containing protein. (147 aa) |
| | ENSRBIP00000008661 | Uncharacterized protein. (250 aa) |
| | ENSRBIP00000008912 | CAF1C_H4-bd domain-containing protein. (55 aa) |
| | GATAD2B | GATA zinc finger domain containing 2B. (593 aa) |
| | NAT10 | RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1026 aa) |
| | ENSRBIP00000010478 | SP-RING-type domain-containing protein. (216 aa) |
| | ENSRBIP00000011182 | Ku domain-containing protein. (328 aa) |
| | H3-4 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | SIRT6 | Sirtuin 6. (355 aa) |
| | ORC3 | ORC_WH_C domain-containing protein. (316 aa) |
| | CDC73 | Cell division cycle 73. (531 aa) |
| | ENSRBIP00000012003 | HTH La-type RNA-binding domain-containing protein. (325 aa) |
| | PPP1R10 | Protein phosphatase 1 regulatory subunit 10. (940 aa) |
| | H2BC3 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | NSMCE1 | NSE1 homolog, SMC5-SMC6 complex component. (303 aa) |
| | ENSRBIP00000012931 | CAF1C_H4-bd domain-containing protein. (100 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa) |
| | MEN1 | Menin 1. (610 aa) |
| | TEP1 | Telomerase associated protein 1. (2633 aa) |
| | LOC108513349 | Uncharacterized protein. (165 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (932 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (347 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (907 aa) |
| | SPO11 | SPO11 initiator of meiotic double stranded breaks. (407 aa) |
| | WRN | WRN RecQ like helicase. (1394 aa) |
| | SMC6 | Structural maintenance of chromosomes 6. (1040 aa) |
| | TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1167 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1943 aa) |
| | NSMCE4A | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (385 aa) |
| | ATF7 | Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (494 aa) |
| | DCLRE1B | DNA cross-link repair 1B. (532 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (641 aa) |
| | TERB2 | Telomere repeat binding bouquet formation protein 2. (200 aa) |
| | PINX1 | PIN2 (TERF1) interacting telomerase inhibitor 1. (327 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (805 aa) |
| | HAT1 | Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (486 aa) |
| | ORC2 | Origin recognition complex subunit 2. (575 aa) |
| | RECQL4 | RecQ like helicase 4. (1197 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (907 aa) |
| | MACROH2A1 | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (667 aa) |
| | EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit. (767 aa) |
| | LOC108522364 | Uncharacterized protein. (389 aa) |
| | ENSRBIP00000022500 | Uncharacterized protein. (185 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (231 aa) |
| | WRAP53 | WD repeat containing antisense to TP53. (549 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa) |
| | SP100 | SP100 nuclear antigen. (823 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | ENSRBIP00000025761 | TINF2_N domain-containing protein. (517 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa) |
| | CBX5 | Chromobox 5. (128 aa) |
| | DHX36 | DEAH-box helicase 36. (971 aa) |
| | TFIP11 | Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...] (837 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1050 aa) |
| | ZSCAN4 | Zinc finger and SCAN domain containing 4. (431 aa) |
| | ENSRBIP00000041364 | Ku domain-containing protein. (498 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (289 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (376 aa) |
| | EID3 | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (426 aa) |
| | TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (406 aa) |
| | ACD | ACD shelterin complex subunit and telomerase recruitment factor. (528 aa) |
| | CCDC155 | Coiled-coil domain containing 155. (562 aa) |
| | CTC1 | CST telomere replication complex component 1. (1217 aa) |
| | ENSRBIP00000037689 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (191 aa) |
| | TINF2 | TINF2_N domain-containing protein. (451 aa) |
| | ZBTB10 | Zinc finger and BTB domain containing 10. (873 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (362 aa) |
| | ENSRBIP00000036862 | Ku domain-containing protein. (567 aa) |
| | SSB | HTH La-type RNA-binding domain-containing protein. (373 aa) |
| | ENSRBIP00000036162 | WD_REPEATS_REGION domain-containing protein. (399 aa) |
| | LOC108531288 | RRM domain-containing protein. (350 aa) |
| | CHD4 | Uncharacterized protein. (1906 aa) |
| | ENSRBIP00000035711 | RAD51_interact domain-containing protein. (282 aa) |
| | ENSRBIP00000035529 | WD_REPEATS_REGION domain-containing protein. (235 aa) |
