STRINGSTRING
TERF2IP TERF2IP PML PML ENSRBIP00000035176 ENSRBIP00000035176 DNA2 DNA2 ENSRBIP00000034985 ENSRBIP00000034985 SETX SETX POT1 POT1 SLX4 SLX4 ENSRBIP00000032469 ENSRBIP00000032469 KDM1A KDM1A STN1 STN1 XRCC6 XRCC6 RAD51 RAD51 ENSRBIP00000031680 ENSRBIP00000031680 ZNF827 ZNF827 SMC5 SMC5 TNKS TNKS ZBTB48 ZBTB48 NABP2 NABP2 MAJIN MAJIN TERB1 TERB1 TELO2 TELO2 TERF2 TERF2 ORC4 ORC4 MCM6 MCM6 MTA2 MTA2 ENSRBIP00000028523 ENSRBIP00000028523 ORC5 ORC5 MCM4 MCM4 MACROH2A2 MACROH2A2 LRWD1 LRWD1 NBN NBN BRCA2 BRCA2 NSMCE2 NSMCE2 H2AC1 H2AC1 TNKS2 TNKS2 RBBP4 RBBP4 RIF1 RIF1 ENSRBIP00000001755 ENSRBIP00000001755 TEN1 TEN1 ENSRBIP00000001977 ENSRBIP00000001977 SUN2 SUN2 UPF1 UPF1 FEN1 FEN1 ENSRBIP00000003378 ENSRBIP00000003378 NABP1 NABP1 RNF8 RNF8 GAR1 GAR1 ORC1 ORC1 SMG6 SMG6 LOC108525285 LOC108525285 CBX1 CBX1 ENSRBIP00000008661 ENSRBIP00000008661 ENSRBIP00000008912 ENSRBIP00000008912 GATAD2B GATAD2B NAT10 NAT10 ENSRBIP00000010478 ENSRBIP00000010478 ENSRBIP00000011182 ENSRBIP00000011182 H3-4 H3-4 SIRT6 SIRT6 ORC3 ORC3 CDC73 CDC73 ENSRBIP00000012003 ENSRBIP00000012003 PPP1R10 PPP1R10 H2BC3 H2BC3 NSMCE1 NSMCE1 ENSRBIP00000012931 ENSRBIP00000012931 PRKDC PRKDC MEN1 MEN1 TEP1 TEP1 LOC108513349 LOC108513349 MSH2 MSH2 XRCC3 XRCC3 ERCC4 ERCC4 SPO11 SPO11 WRN WRN SMC6 SMC6 TERT TERT TP53BP1 TP53BP1 NSMCE4A NSMCE4A ATF7 ATF7 DCLRE1B DCLRE1B MCM7 MCM7 PIF1 PIF1 TERB2 TERB2 PINX1 PINX1 XRCC5 XRCC5 HAT1 HAT1 ORC2 ORC2 RECQL4 RECQL4 MCM2 MCM2 MACROH2A1 MACROH2A1 MRE11 MRE11 EZH2 EZH2 LOC108522364 LOC108522364 ENSRBIP00000022500 ENSRBIP00000022500 MCM5 MCM5 XRCC4 XRCC4 WRAP53 WRAP53 HDAC2 HDAC2 SP100 SP100 RPA1 RPA1 ENSRBIP00000025761 ENSRBIP00000025761 PARP1 PARP1 CBX5 CBX5 DHX36 DHX36 TFIP11 TFIP11 SLF1 SLF1 ZSCAN4 ZSCAN4 ENSRBIP00000041364 ENSRBIP00000041364 ERCC1 ERCC1 DMC1 DMC1 EID3 EID3 TERF1 TERF1 ACD ACD CCDC155 CCDC155 CTC1 CTC1 ENSRBIP00000037689 ENSRBIP00000037689 TINF2 TINF2 ZBTB10 ZBTB10 CDK2 CDK2 ENSRBIP00000036862 ENSRBIP00000036862 SSB SSB ENSRBIP00000036162 ENSRBIP00000036162 LOC108531288 LOC108531288 CHD4 CHD4 ENSRBIP00000035711 ENSRBIP00000035711 ENSRBIP00000035529 ENSRBIP00000035529
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TERF2IPTERF2 interacting protein. (400 aa)
PMLPromyelocytic leukemia. (932 aa)
ENSRBIP00000035176Uncharacterized protein. (360 aa)
DNA2DNA replication helicase/nuclease 2. (1047 aa)
ENSRBIP00000034985TINF2_N domain-containing protein. (339 aa)
SETXSenataxin. (2655 aa)
POT1Protection of telomeres 1. (633 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1814 aa)
ENSRBIP00000032469Uncharacterized protein. (153 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (883 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
XRCC6X-ray repair cross complementing 6. (568 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (337 aa)
ENSRBIP00000031680WD_REPEATS_REGION domain-containing protein. (408 aa)
ZNF827Zinc finger protein 827. (1071 aa)
SMC5Structural maintenance of chromosomes 5. (1054 aa)
TNKSPoly [ADP-ribose] polymerase. (1276 aa)
ZBTB48Zinc finger and BTB domain containing 48. (813 aa)
NABP2Nucleic acid binding protein 2. (211 aa)
MAJINMembrane anchored junction protein. (254 aa)
TERB1Telomere repeat binding bouquet formation protein 1. (674 aa)
TELO2Telomere maintenance 2. (836 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (421 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (435 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
MTA2Metastasis associated 1 family member 2. (673 aa)
ENSRBIP00000028523ChSh domain-containing protein. (217 aa)
ORC5Origin recognition complex subunit 5. (424 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
MACROH2A2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
LRWD1Leucine rich repeats and WD repeat domain containing 1. (681 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (752 aa)
BRCA2Uncharacterized protein. (386 aa)
NSMCE2SP-RING-type domain-containing protein. (246 aa)
H2AC1Histone H2A; Belongs to the histone H2A family. (131 aa)
TNKS2Poly [ADP-ribose] polymerase. (1165 aa)
RBBP4WD_REPEATS_REGION domain-containing protein. (419 aa)
RIF1Replication timing regulatory factor 1. (2444 aa)
ENSRBIP00000001755Uncharacterized protein. (218 aa)
TEN1Uncharacterized protein. (123 aa)
ENSRBIP00000001977HMG box domain-containing protein. (580 aa)
SUN2Sad1 and UNC84 domain containing 2. (721 aa)
UPF1UPF1 RNA helicase and ATPase. (1068 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
ENSRBIP00000003378Metallophos domain-containing protein. (233 aa)
NABP1Nucleic acid binding protein 1. (204 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (468 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (217 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (858 aa)
SMG6SMG6 nonsense mediated mRNA decay factor. (1419 aa)
LOC108525285Uncharacterized protein. (274 aa)
CBX1Chromo domain-containing protein. (147 aa)
ENSRBIP00000008661Uncharacterized protein. (250 aa)
ENSRBIP00000008912CAF1C_H4-bd domain-containing protein. (55 aa)
GATAD2BGATA zinc finger domain containing 2B. (593 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1026 aa)
ENSRBIP00000010478SP-RING-type domain-containing protein. (216 aa)
ENSRBIP00000011182Ku domain-containing protein. (328 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
SIRT6Sirtuin 6. (355 aa)
ORC3ORC_WH_C domain-containing protein. (316 aa)
CDC73Cell division cycle 73. (531 aa)
ENSRBIP00000012003HTH La-type RNA-binding domain-containing protein. (325 aa)
PPP1R10Protein phosphatase 1 regulatory subunit 10. (940 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
NSMCE1NSE1 homolog, SMC5-SMC6 complex component. (303 aa)
ENSRBIP00000012931CAF1C_H4-bd domain-containing protein. (100 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa)
MEN1Menin 1. (610 aa)
TEP1Telomerase associated protein 1. (2633 aa)
LOC108513349Uncharacterized protein. (165 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (932 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (347 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (907 aa)
SPO11SPO11 initiator of meiotic double stranded breaks. (407 aa)
WRNWRN RecQ like helicase. (1394 aa)
SMC6Structural maintenance of chromosomes 6. (1040 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1167 aa)
TP53BP1Tumor protein p53 binding protein 1. (1943 aa)
NSMCE4ANon-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (385 aa)
ATF7Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (494 aa)
DCLRE1BDNA cross-link repair 1B. (532 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (641 aa)
TERB2Telomere repeat binding bouquet formation protein 2. (200 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (327 aa)
XRCC5X-ray repair cross complementing 5. (805 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (486 aa)
ORC2Origin recognition complex subunit 2. (575 aa)
RECQL4RecQ like helicase 4. (1197 aa)
MCM2DNA helicase; Belongs to the MCM family. (907 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (667 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (767 aa)
LOC108522364Uncharacterized protein. (389 aa)
ENSRBIP00000022500Uncharacterized protein. (185 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
XRCC4X-ray repair cross complementing 4. (231 aa)
WRAP53WD repeat containing antisense to TP53. (549 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
SP100SP100 nuclear antigen. (823 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
ENSRBIP00000025761TINF2_N domain-containing protein. (517 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
CBX5Chromobox 5. (128 aa)
DHX36DEAH-box helicase 36. (971 aa)
TFIP11Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...] (837 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1050 aa)
ZSCAN4Zinc finger and SCAN domain containing 4. (431 aa)
ENSRBIP00000041364Ku domain-containing protein. (498 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (289 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (376 aa)
EID3Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (426 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (406 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (528 aa)
CCDC155Coiled-coil domain containing 155. (562 aa)
CTC1CST telomere replication complex component 1. (1217 aa)
ENSRBIP00000037689H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (191 aa)
TINF2TINF2_N domain-containing protein. (451 aa)
ZBTB10Zinc finger and BTB domain containing 10. (873 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (362 aa)
ENSRBIP00000036862Ku domain-containing protein. (567 aa)
SSBHTH La-type RNA-binding domain-containing protein. (373 aa)
ENSRBIP00000036162WD_REPEATS_REGION domain-containing protein. (399 aa)
LOC108531288RRM domain-containing protein. (350 aa)
CHD4Uncharacterized protein. (1906 aa)
ENSRBIP00000035711RAD51_interact domain-containing protein. (282 aa)
ENSRBIP00000035529WD_REPEATS_REGION domain-containing protein. (235 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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