STRINGSTRING
ESR1 ESR1 RUNX1 RUNX1 THRB THRB RORA RORA SMAD3 SMAD3 CIT CIT GATA1 GATA1 PPARA PPARA HAND2 HAND2 MED25 MED25 ZBTB8A ZBTB8A RARA RARA NFKB1 NFKB1 TRERF1 TRERF1 VGLL4 VGLL4 GATA3 GATA3 ZBTB17 ZBTB17 HNF1A HNF1A MED1 MED1 TFAM TFAM TERT TERT ATF7 ATF7 EPAS1 EPAS1 RELA RELA LOC108522656 LOC108522656 SMAD4 SMAD4 CCNT2 CCNT2 NFATC1 NFATC1 TEAD2 TEAD2 GATA2 GATA2 CDK9 CDK9 CREBBP CREBBP ZBTB49 ZBTB49 EP300 EP300 PPARD PPARD STAT1 STAT1 ENSRBIP00000038500 ENSRBIP00000038500 HIF1A HIF1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
RUNX1RUNX family transcription factor 1. (264 aa)
THRBThyroid hormone receptor beta. (476 aa)
RORARAR related orphan receptor A. (555 aa)
SMAD3Mothers against decapentaplegic homolog. (480 aa)
CITCitron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2024 aa)
GATA1GATA binding protein 1. (421 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
MED25Mediator complex subunit 25. (707 aa)
ZBTB8AZinc finger and BTB domain containing 8A. (384 aa)
RARARetinoic acid receptor alpha. (478 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
TRERF1Transcriptional regulating factor 1. (1199 aa)
VGLL4Vestigial like family member 4. (296 aa)
GATA3GATA binding protein 3. (444 aa)
ZBTB17Zinc finger and BTB domain containing 17. (803 aa)
HNF1AHNF1 homeobox A. (662 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1547 aa)
TFAMTranscription factor A, mitochondrial. (251 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1167 aa)
ATF7Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (494 aa)
EPAS1Endothelial PAS domain protein 1. (865 aa)
RELAUncharacterized protein. (282 aa)
LOC108522656NR LBD domain-containing protein. (344 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (721 aa)
NFATC1Nuclear factor of activated T cells 1. (989 aa)
TEAD2TEA domain transcription factor 2. (390 aa)
GATA2GATA binding protein 2. (468 aa)
CDK9Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
CREBBPCREB binding protein. (2422 aa)
ZBTB49Zinc finger and BTB domain containing 49. (764 aa)
EP300E1A binding protein p300. (2296 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
ENSRBIP00000038500RHD domain-containing protein. (112 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
Server load: low (26%) [HD]