105 items (Rhinopithecus bieti) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CD81	CD81 molecule; Belongs to the tetraspanin (TM4SF) family. (252 aa)
	CD226	CD226 molecule. (356 aa)
	LOC108529932	FAM35_C domain-containing protein. (210 aa)
	BTK	Tyrosine-protein kinase. (673 aa)
	PAXIP1	PAX interacting protein 1. (1086 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
	HMCES	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (354 aa)
	CD1D	CD1d molecule. (337 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1310 aa)
	TBX21	T-box transcription factor 21. (524 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
	IL18R1	Interleukin 18 receptor 1. (525 aa)
	NSD2	Nuclear receptor binding SET domain protein 2. (1368 aa)
	LOC108536663	MHC_I-like_Ag-recog domain-containing protein. (299 aa)
	SLAMF6	SLAM family member 6. (332 aa)
	LAMP1	Lysosomal associated membrane protein 1. (415 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
	TFRC	Transferrin receptor. (760 aa)
	PRKCZ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
	CD1B	CD1b molecule. (333 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	CD40	CD40 molecule. (278 aa)
	VAV1	Vav guanine nucleotide exchange factor 1. (843 aa)
	ENSRBIP00000033534	MHC_I-like_Ag-recog domain-containing protein. (227 aa)
	KLRK1	Killer cell lectin like receptor K1. (204 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
	HPX	Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (462 aa)
	KIR2DL4	Uncharacterized protein. (357 aa)
	CD1E	CD1e molecule. (387 aa)
	ARID5A	AT-rich interaction domain 5A. (702 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
	LOC108538696	Uncharacterized protein. (351 aa)
	CADM1	Cell adhesion molecule 1. (473 aa)
	KMT5B	Lysine methyltransferase 5B. (870 aa)
	CD1A	CD1a molecule. (323 aa)
	RSAD2	Radical S-adenosyl methionine domain containing 2. (360 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (231 aa)
	SH2D1B	SH2 domain containing 1B. (132 aa)
	DENND1B	DENN domain containing 1B. (711 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	SHLD2	FAM35_C domain-containing protein. (905 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	SASH3	SAM and SH3 domain containing 3. (357 aa)
	CRTAM	Cytotoxic and regulatory T cell molecule. (344 aa)
	KMT5C	Lysine methyltransferase 5C. (461 aa)
	HLA-E	Major histocompatibility complex, class I, E; Belongs to the MHC class I family. (359 aa)
	C17orf99	Chromosome 17 open reading frame 99. (265 aa)
	ENSRBIP00000024399	Uncharacterized protein; Belongs to the tetraspanin (TM4SF) family. (124 aa)
	FAM49B	Family with sequence similarity 49 member B. (324 aa)
	HLA-F	Major histocompatibility complex, class I, F; Belongs to the MHC class I family. (369 aa)
	IL23A	Interleukin 23 subunit alpha. (189 aa)
	LOC108531166	AIG1-type G domain-containing protein. (307 aa)
	NCR3	Natural cytotoxicity triggering receptor 3. (180 aa)
	LAG3	Lymphocyte activating 3. (525 aa)
	SLAMF1	Signaling lymphocytic activation molecule family member 1. (357 aa)
	FBXO38	F-box protein 38. (1188 aa)
	FOXP3	Forkhead box P3. (456 aa)
	TNFSF4	TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
	IL12RB1	Interleukin 12 receptor subunit beta 1. (652 aa)
	SLC22A13	Solute carrier family 22 member 13. (551 aa)
	LTA	Lymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa)
	KIR3DL3	Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3. (428 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
	CD1C	CD1c molecule. (332 aa)
	TP53BP1	Tumor protein p53 binding protein 1. (1943 aa)
	STAT5B	Signal transducer and activator of transcription. (768 aa)
	MALT1	MALT1 paracaspase. (811 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (932 aa)
	RASGRP1	RAS guanyl releasing protein 1. (841 aa)
	CD55	CD55 molecule (Cromer blood group). (535 aa)
	GATA3	GATA binding protein 3. (444 aa)
	IL23R	Interleukin 23 receptor. (629 aa)
	CD28	CD28 molecule. (220 aa)
	CD160	CD160 molecule. (232 aa)
	MR1	Major histocompatibility complex, class I-related; Belongs to the MHC class I family. (340 aa)
	ENSRBIP00000011851	Uncharacterized protein. (107 aa)
	STX7	Syntaxin 7; Belongs to the syntaxin family. (261 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
	STAT6	Signal transducer and activator of transcription. (847 aa)
	CLCF1	Cardiotrophin like cytokine factor 1. (322 aa)
	ATAD5	ATPase family AAA domain containing 5. (1718 aa)
	IL1R1	Interleukin 1 receptor type 1. (568 aa)
	NECTIN2	Nectin cell adhesion molecule 2. (573 aa)
	CLNK	Cytokine dependent hematopoietic cell linker. (428 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
	C3	Complement C3. (1598 aa)
	MLH1	MutL homolog 1. (754 aa)
	MAD2L2	Mitotic arrest deficient 2 like 2. (218 aa)
	ENSRBIP00000006958	TNF receptor-associated factor. (473 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	NLRP3	NLR family pyrin domain containing 3. (1035 aa)
	KLRD1	Killer cell lectin like receptor D1. (179 aa)
	EXOSC3	Exosome component 3. (275 aa)
	SHLD1	Shieldin complex subunit 1. (254 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	FZD5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
	ENSRBIP00000004373	Ig-like domain-containing protein; Belongs to the MHC class I family. (391 aa)
	FCER2	Fc fragment of IgE receptor II. (321 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1153 aa)
	PVR	Ig-like domain-containing protein. (240 aa)
	SH2D1A	SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (128 aa)
	RIF1	Replication timing regulatory factor 1. (2444 aa)
	ZBTB1	Zinc finger and BTB domain containing 1. (668 aa)
	EXOSC6	Exosome component 6. (272 aa)
	ENSRBIP00000000175	MHC_I-like_Ag-recog domain-containing protein. (233 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	B2M	ENSRBIP00000009860	ENSRBIP00000008388	ATPase family AAA domain containing 5.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.553
ATAD5	MAD2L2	ENSRBIP00000009860	ENSRBIP00000007018	ATPase family AAA domain containing 5.	Mitotic arrest deficient 2 like 2.	0.643
ATAD5	MSH2	ENSRBIP00000009860	ENSRBIP00000014641	ATPase family AAA domain containing 5.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.441
B2M	ATAD5	ENSRBIP00000008388	ENSRBIP00000009860	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	ATPase family AAA domain containing 5.	0.553
B2M	CD1A	ENSRBIP00000008388	ENSRBIP00000027916	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD1a molecule.	0.681
B2M	CD1B	ENSRBIP00000008388	ENSRBIP00000036787	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD1b molecule.	0.681
B2M	CD1C	ENSRBIP00000008388	ENSRBIP00000017662	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD1c molecule.	0.681
B2M	CD1D	ENSRBIP00000008388	ENSRBIP00000040932	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD1d molecule.	0.985
B2M	CD1E	ENSRBIP00000008388	ENSRBIP00000031575	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD1e molecule.	0.681
B2M	ENSRBIP00000004373	ENSRBIP00000008388	ENSRBIP00000004373	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.889
B2M	HLA-E	ENSRBIP00000008388	ENSRBIP00000024931	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Major histocompatibility complex, class I, E; Belongs to the MHC class I family.	0.989
B2M	HLA-F	ENSRBIP00000008388	ENSRBIP00000023508	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Major histocompatibility complex, class I, F; Belongs to the MHC class I family.	0.969
B2M	KLRD1	ENSRBIP00000008388	ENSRBIP00000006110	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Killer cell lectin like receptor D1.	0.639
B2M	MAD2L2	ENSRBIP00000008388	ENSRBIP00000007018	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Mitotic arrest deficient 2 like 2.	0.523
B2M	MLH1	ENSRBIP00000008388	ENSRBIP00000007384	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	MutL homolog 1.	0.435
B2M	MR1	ENSRBIP00000008388	ENSRBIP00000012006	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Major histocompatibility complex, class I-related; Belongs to the MHC class I family.	0.640
B2M	MSH2	ENSRBIP00000008388	ENSRBIP00000014641	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.646
B2M	TFRC	ENSRBIP00000008388	ENSRBIP00000037571	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Transferrin receptor.	0.754
BTK	ENSRBIP00000006958	ENSRBIP00000042366	ENSRBIP00000006958	Tyrosine-protein kinase.	TNF receptor-associated factor.	0.425
BTK	PTPRC	ENSRBIP00000042366	ENSRBIP00000040406	Tyrosine-protein kinase.	Protein tyrosine phosphatase receptor type C.	0.410