72 items (Rhinopithecus bieti) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ZBTB1	Zinc finger and BTB domain containing 1. (668 aa)
	RIPK3	Receptor interacting serine/threonine kinase 3. (518 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (524 aa)
	PVR	Ig-like domain-containing protein. (240 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1153 aa)
	DUSP22	Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (205 aa)
	ENSRBIP00000004373	Ig-like domain-containing protein; Belongs to the MHC class I family. (391 aa)
	IFNB1	Interferon beta 1. (187 aa)
	FZD5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	KLRD1	Killer cell lectin like receptor D1. (179 aa)
	NLRP3	NLR family pyrin domain containing 3. (1035 aa)
	ENSRBIP00000006958	TNF receptor-associated factor. (473 aa)
	FUT7	Fucosyltransferase 7. (342 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
	NECTIN2	Nectin cell adhesion molecule 2. (573 aa)
	IL1R1	Interleukin 1 receptor type 1. (568 aa)
	CEACAM1	Uncharacterized protein. (525 aa)
	STX7	Syntaxin 7; Belongs to the syntaxin family. (261 aa)
	ENSRBIP00000011851	Uncharacterized protein. (107 aa)
	MR1	Major histocompatibility complex, class I-related; Belongs to the MHC class I family. (340 aa)
	LOC108518721	Ig-like domain-containing protein. (407 aa)
	IL23R	Interleukin 23 receptor. (629 aa)
	CLEC4G	C-type lectin domain family 4 member G. (293 aa)
	GATA3	GATA binding protein 3. (444 aa)
	CD55	CD55 molecule (Cromer blood group). (535 aa)
	IL7R	Interleukin 7 receptor. (459 aa)
	MALT1	MALT1 paracaspase. (811 aa)
	NCKAP1L	NCK associated protein 1 like. (1134 aa)
	HFE	Homeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
	CD1C	CD1c molecule. (332 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
	SLC22A13	Solute carrier family 22 member 13. (551 aa)
	CCR2	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	IL12RB1	Interleukin 12 receptor subunit beta 1. (652 aa)
	TNFSF4	TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
	FOXP3	Forkhead box P3. (456 aa)
	WAS	WASP actin nucleation promoting factor. (455 aa)
	CD1D	CD1d molecule. (337 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1310 aa)
	TBX21	T-box transcription factor 21. (524 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
	IL18R1	Interleukin 18 receptor 1. (525 aa)
	PRKCZ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
	CD1B	CD1b molecule. (333 aa)
	LOC108524385	Uncharacterized protein. (348 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
	CD1E	CD1e molecule. (387 aa)
	ARID5A	AT-rich interaction domain 5A. (702 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
	ARG1	Arginase. (322 aa)
	SMAD7	Mothers against decapentaplegic homolog. (431 aa)
	TRPM4	Transient receptor potential cation channel subfamily M member 4. (1052 aa)
	CD1A	CD1a molecule. (323 aa)
	RSAD2	Radical S-adenosyl methionine domain containing 2. (360 aa)
	DENND1B	DENN domain containing 1B. (711 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	SASH3	SAM and SH3 domain containing 3. (357 aa)
	HLA-E	Major histocompatibility complex, class I, E; Belongs to the MHC class I family. (359 aa)
	ENSRBIP00000024399	Uncharacterized protein; Belongs to the tetraspanin (TM4SF) family. (124 aa)
	TNFRSF1B	TNF receptor superfamily member 1B. (462 aa)
	FAM49B	Family with sequence similarity 49 member B. (324 aa)
	HLA-F	Major histocompatibility complex, class I, F; Belongs to the MHC class I family. (369 aa)
	IL23A	Interleukin 23 subunit alpha. (189 aa)
	AGER	Uncharacterized protein. (417 aa)
	CD81	CD81 molecule; Belongs to the tetraspanin (TM4SF) family. (252 aa)
	SLAMF1	Signaling lymphocytic activation molecule family member 1. (357 aa)
	FBXO38	F-box protein 38. (1188 aa)
	IL20RB	Interleukin 20 receptor subunit beta. (311 aa)
	IL4I1	Amine oxidase. (579 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGER	IL4	ENSRBIP00000023070	ENSRBIP00000040124	Uncharacterized protein.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.451
ARG1	CCR2	ENSRBIP00000028204	ENSRBIP00000019067	Arginase.	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.400
ARG1	IL1B	ENSRBIP00000028204	ENSRBIP00000017788	Arginase.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.570
ARG1	IL4	ENSRBIP00000028204	ENSRBIP00000040124	Arginase.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.578
B2M	CD1A	ENSRBIP00000008388	ENSRBIP00000027916	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD1a molecule.	0.681
B2M	CD1B	ENSRBIP00000008388	ENSRBIP00000036787	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD1b molecule.	0.681
B2M	CD1C	ENSRBIP00000008388	ENSRBIP00000017662	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD1c molecule.	0.681
B2M	CD1D	ENSRBIP00000008388	ENSRBIP00000040932	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD1d molecule.	0.985
B2M	CD1E	ENSRBIP00000008388	ENSRBIP00000031575	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD1e molecule.	0.681
B2M	ENSRBIP00000004373	ENSRBIP00000008388	ENSRBIP00000004373	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.889
B2M	HFE	ENSRBIP00000008388	ENSRBIP00000017419	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Homeostatic iron regulator; Belongs to the MHC class I family.	0.924
B2M	HLA-E	ENSRBIP00000008388	ENSRBIP00000024931	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Major histocompatibility complex, class I, E; Belongs to the MHC class I family.	0.989
B2M	HLA-F	ENSRBIP00000008388	ENSRBIP00000023508	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Major histocompatibility complex, class I, F; Belongs to the MHC class I family.	0.969
B2M	KLRD1	ENSRBIP00000008388	ENSRBIP00000006110	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Killer cell lectin like receptor D1.	0.639
B2M	MR1	ENSRBIP00000008388	ENSRBIP00000012006	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Major histocompatibility complex, class I-related; Belongs to the MHC class I family.	0.640
CCR2	ARG1	ENSRBIP00000019067	ENSRBIP00000028204	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family.	Arginase.	0.400
CCR2	IL1B	ENSRBIP00000019067	ENSRBIP00000017788	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.531
CCR2	PTPRC	ENSRBIP00000019067	ENSRBIP00000040406	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family.	Protein tyrosine phosphatase receptor type C.	0.435
CD1A	B2M	ENSRBIP00000027916	ENSRBIP00000008388	CD1a molecule.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.681
CD1A	CD1B	ENSRBIP00000027916	ENSRBIP00000036787	CD1a molecule.	CD1b molecule.	0.667