STRINGSTRING
UHRF1 UHRF1 POLD3 POLD3 POLA2 POLA2 RAD18 RAD18 HMCES HMCES RFC3 RFC3 SMARCAD1 SMARCAD1 ENSRBIP00000034615 ENSRBIP00000034615 MUS81 MUS81 RFC1 RFC1 RPA3 RPA3 DMAP1 DMAP1 MCM10 MCM10 PRIM2 PRIM2 SMARCAL1 SMARCAL1 ZRANB3 ZRANB3 MMS22L MMS22L XRCC2 XRCC2 PRIMPOL PRIMPOL RFC5 RFC5 TP53 TP53 DNMT1 DNMT1 RFC4 RFC4 POLD2 POLD2 WDHD1 WDHD1 RPA1 RPA1 POLD4 POLD4 RPA2 RPA2 RAD51B RAD51B TIPIN TIPIN MRE11 MRE11 RFC2 RFC2 TEX264 TEX264 ZMIZ2 ZMIZ2 PIF1 PIF1 POLD1 POLD1 LOC108537870 LOC108537870 EME2 EME2 TP53BP1 TP53BP1 WRN WRN RAD51C RAD51C DNMT1-2 DNMT1-2 XRCC3 XRCC3 ENSRBIP00000013617 ENSRBIP00000013617 RTF2 RTF2 BLM BLM POLH POLH PCNA PCNA ETAA1 ETAA1 ENSRBIP00000003378 ENSRBIP00000003378 TONSL TONSL TIMELESS TIMELESS ENSRBIP00000000804 ENSRBIP00000000804 DONSON DONSON
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UHRF1Ubiquitin like with PHD and ring finger domains 1. (859 aa)
POLD3Uncharacterized protein. (454 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
RAD18RAD18 E3 ubiquitin protein ligase. (494 aa)
HMCESAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (354 aa)
RFC3Replication factor C subunit 3. (356 aa)
SMARCAD1Uncharacterized protein. (1026 aa)
ENSRBIP00000034615TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (275 aa)
MUS81MUS81 structure-specific endonuclease subunit. (551 aa)
RFC1Replication factor C subunit 1. (1114 aa)
RPA3Replication protein A3. (121 aa)
DMAP1DNA methyltransferase 1 associated protein 1. (467 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (904 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (486 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (959 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (998 aa)
MMS22LMMS22 like, DNA repair protein. (1243 aa)
XRCC2X-ray repair cross complementing 2. (281 aa)
PRIMPOLPrimase and DNA directed polymerase. (551 aa)
RFC5Replication factor C subunit 5. (309 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1482 aa)
RFC4Replication factor C subunit 4. (362 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
WDHD1WD repeat and HMG-box DNA binding protein 1. (1123 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
POLD4Uncharacterized protein. (107 aa)
RPA2Replication protein A2. (273 aa)
RAD51BRAD51 paralog B. (426 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (288 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (667 aa)
RFC2Replication factor C subunit 2. (352 aa)
TEX264Testis expressed 264, ER-phagy receptor. (313 aa)
ZMIZ2Zinc finger MIZ-type containing 2. (920 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (641 aa)
POLD1DNA polymerase. (1124 aa)
LOC108537870Uncharacterized protein. (322 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (377 aa)
TP53BP1Tumor protein p53 binding protein 1. (1943 aa)
WRNWRN RecQ like helicase. (1394 aa)
RAD51CRAD51 paralog C. (376 aa)
DNMT1-2DMAP-interaction domain-containing protein. (89 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (347 aa)
ENSRBIP00000013617Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (245 aa)
RTF2Replication termination factor 2. (329 aa)
BLMBLM RecQ like helicase. (1396 aa)
POLHDNA polymerase eta. (697 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
ETAA1ETAA1 activator of ATR kinase. (822 aa)
ENSRBIP00000003378Metallophos domain-containing protein. (233 aa)
TONSLTonsoku like, DNA repair protein. (1367 aa)
TIMELESSTimeless circadian regulator. (1208 aa)
ENSRBIP00000000804RPA_C domain-containing protein. (235 aa)
DONSONDownstream neighbor of SON. (548 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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