113 items (Rhinopithecus bieti) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GALM	Aldose 1-epimerase; Converts alpha-aldose to the beta-anomer. (344 aa)
	ENSRBIP00000020118	Uncharacterized protein. (222 aa)
	ENSRBIP00000020149	Uncharacterized protein. (395 aa)
	TKTL1	Transketolase like 1. (596 aa)
	HECTD4	HECT domain E3 ubiquitin protein ligase 4. (4416 aa)
	CRTC2	CREB regulated transcription coactivator 2. (699 aa)
	HK2	Hexokinase 2. (917 aa)
	GCK	Phosphotransferase. (466 aa)
	CRY1	Cryptochrome circadian regulator 1. (586 aa)
	FBP1	Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (293 aa)
	PGAM2	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
	G6PC3	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
	SERPINA12	Serpin family A member 12; Belongs to the serpin family. (414 aa)
	ENSRBIP00000023654	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (612 aa)
	PGM1	Phosphoglucomutase 1; Belongs to the phosphohexose mutase family. (580 aa)
	PFKFB1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (452 aa)
	HK3	Hexokinase 3. (960 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (574 aa)
	ATF3	Activating transcription factor 3. (181 aa)
	GCG	Glucagon. (180 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	LEPR	Leptin receptor. (1169 aa)
	ENO2	Enolase 2. (434 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
	GHRL	Ghrelin and obestatin prepropeptide. (117 aa)
	KBTBD2	Kelch repeat and BTB domain containing 2. (326 aa)
	PFKM	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
	ENSRBIP00000030628	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (118 aa)
	PDK1	Protein-serine/threonine kinase. (436 aa)
	PDX1	Pancreatic and duodenal homeobox 1. (284 aa)
	LOC108528963	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (791 aa)
	GPI	Glucose-6-phosphate isomerase; Belongs to the GPI family. (573 aa)
	TFAP2B	Transcription factor AP-2 beta. (442 aa)
	INPPL1	Inositol polyphosphate phosphatase like 1. (1257 aa)
	WDTC1	WD and tetratricopeptide repeats 1. (666 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	ENO3	Uncharacterized protein. (433 aa)
	PCK2	Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
	TSTD1	Thiosulfate sulfurtransferase like domain containing 1. (115 aa)
	TPI1	Triosephosphate isomerase. (286 aa)
	PDK4	Protein-serine/threonine kinase. (411 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (441 aa)
	FOXK1	Forkhead box K1. (616 aa)
	ENSRBIP00000036593	Triosephosphate isomerase. (140 aa)
	H6PD	Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. (802 aa)
	DCXR	Dicarbonyl and L-xylulose reductase. (244 aa)
	GPD1	Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
	NPY1R	Neuropeptide Y receptor Y1; Belongs to the G-protein coupled receptor 1 family. (383 aa)
	ENSRBIP00000038661	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (104 aa)
	IGF2	Insulin like growth factor 2. (236 aa)
	G6PC	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
	PGM2L1	Phosphoglucomutase 2 like 1. (625 aa)
	PGM2	Phosphoglucomutase 2. (622 aa)
	OMA1	OMA1 zinc metallopeptidase. (524 aa)
	WDR5	WD repeat domain 5. (334 aa)
	SLC25A10	Solute carrier family 25 member 10; Belongs to the mitochondrial carrier (TC 2.A.29) family. (355 aa)
	G6PD	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (545 aa)
	PDK2	Protein-serine/threonine kinase. (559 aa)
	FBP2	Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (339 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (275 aa)
	ENSRBIP00000011405	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (348 aa)
	ENSRBIP00000040599	Triosephosphate isomerase. (267 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	FBN1	Fibrillin 1. (2871 aa)
	KCNQ1	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (452 aa)
	BAD	BCL2 associated agonist of cell death. (167 aa)
	AKT1	AKT serine/threonine kinase 1. (486 aa)
	G6PC2	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (354 aa)
	APOD	Apolipoprotein D. (215 aa)
	PER2	Period circadian regulator 2. (1311 aa)
	SLC25A1	Solute carrier family 25 member 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (423 aa)
	DLAT	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (647 aa)
	CDV3	CDV3 homolog. (244 aa)
	PC	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1179 aa)
	LRP5L	LDL receptor related protein 5 like. (251 aa)
	ENSRBIP00000042810	Uncharacterized protein. (113 aa)
	ENSRBIP00000043645	Uncharacterized protein. (401 aa)
	PDHA1	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (382 aa)
	KAT2B	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (798 aa)
	TIGAR	TP53 induced glycolysis regulatory phosphatase. (316 aa)
	HKDC1	Hexokinase domain containing 1. (917 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (468 aa)
	PDK3	Protein-serine/threonine kinase. (363 aa)
	ENSRBIP00000006642	Enolase_C domain-containing protein. (184 aa)
	KAT2A	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
	FOXK2	Forkhead box K2. (548 aa)
	KCNJ11	Potassium voltage-gated channel subfamily J member 11. (390 aa)
	FABP5-2	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
	PDHA2	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (388 aa)
	ENSRBIP00000003284	Gp_dh_N domain-containing protein. (260 aa)
	TKTL2	Transketolase like 2. (722 aa)
	ENSRBIP00000002993	Uncharacterized protein. (237 aa)
	CPT1A	Carnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (762 aa)
	ENSRBIP00000001673	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (101 aa)
	BRAT1	BRCA1 associated ATM activator 1. (821 aa)
	SLC37A4	Solute carrier family 37 member 4. (451 aa)
	ENSRBIP00000000642	FABP domain-containing protein. (121 aa)
	OAS1	2'-5'-oligoadenylate synthetase 1. (408 aa)
	PDHB	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
	GDPGP1	Uncharacterized protein. (385 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	FABP5	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (115 aa)
	SLC39A14	Solute carrier family 39 member 14. (489 aa)
	IRS2	Insulin receptor substrate 2. (904 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (798 aa)
	ATF4	Activating transcription factor 4. (351 aa)
	SDS	Serine dehydratase. (328 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	RBP4	Retinol-binding protein; Retinol-binding protein that mediates retinol transport in blood plasma. (201 aa)
	ENSRBIP00000018495	Glyceraldehyde-3-phosphate dehydrogenase. (321 aa)
	ENO1	Enolase 1. (382 aa)
	C1QTNF12	C1q and TNF related 12. (278 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	GHRL	ENSRBIP00000011648	ENSRBIP00000029484	Adiponectin, C1Q and collagen domain containing.	Ghrelin and obestatin prepropeptide.	0.557
ADIPOQ	INS	ENSRBIP00000011648	ENSRBIP00000015729	Adiponectin, C1Q and collagen domain containing.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.653
ADIPOQ	LEP	ENSRBIP00000011648	ENSRBIP00000041070	Adiponectin, C1Q and collagen domain containing.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.833
ADIPOQ	LEPR	ENSRBIP00000011648	ENSRBIP00000028381	Adiponectin, C1Q and collagen domain containing.	Leptin receptor.	0.564
ADIPOQ	PPARA	ENSRBIP00000011648	ENSRBIP00000007565	Adiponectin, C1Q and collagen domain containing.	Peroxisome proliferator activated receptor alpha.	0.609
ADIPOQ	PPARGC1A	ENSRBIP00000011648	ENSRBIP00000016637	Adiponectin, C1Q and collagen domain containing.	PPARG coactivator 1 alpha.	0.611
ADIPOQ	RBP4	ENSRBIP00000011648	ENSRBIP00000017822	Adiponectin, C1Q and collagen domain containing.	Retinol-binding protein; Retinol-binding protein that mediates retinol transport in blood plasma.	0.440
AKT1	AKT2	ENSRBIP00000010710	ENSRBIP00000034007	AKT serine/threonine kinase 1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.708
AKT1	BAD	ENSRBIP00000010710	ENSRBIP00000041804	AKT serine/threonine kinase 1.	BCL2 associated agonist of cell death.	0.823
AKT1	ENSRBIP00000018495	ENSRBIP00000010710	ENSRBIP00000018495	AKT serine/threonine kinase 1.	Glyceraldehyde-3-phosphate dehydrogenase.	0.595
AKT1	HK2	ENSRBIP00000010710	ENSRBIP00000021190	AKT serine/threonine kinase 1.	Hexokinase 2.	0.479
AKT1	HK3	ENSRBIP00000010710	ENSRBIP00000025559	AKT serine/threonine kinase 1.	Hexokinase 3.	0.403
AKT1	HKDC1	ENSRBIP00000010710	ENSRBIP00000007605	AKT serine/threonine kinase 1.	Hexokinase domain containing 1.	0.403
AKT1	IGF2	ENSRBIP00000010710	ENSRBIP00000038768	AKT serine/threonine kinase 1.	Insulin like growth factor 2.	0.444
AKT1	INPPL1	ENSRBIP00000010710	ENSRBIP00000033248	AKT serine/threonine kinase 1.	Inositol polyphosphate phosphatase like 1.	0.587
AKT1	INS	ENSRBIP00000010710	ENSRBIP00000015729	AKT serine/threonine kinase 1.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.580
AKT1	IRS2	ENSRBIP00000010710	ENSRBIP00000016567	AKT serine/threonine kinase 1.	Insulin receptor substrate 2.	0.624
AKT1	LEP	ENSRBIP00000010710	ENSRBIP00000041070	AKT serine/threonine kinase 1.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.551
AKT1	MAPK14	ENSRBIP00000010710	ENSRBIP00000027919	AKT serine/threonine kinase 1.	Mitogen-activated protein kinase.	0.623
AKT1	PDK1	ENSRBIP00000010710	ENSRBIP00000030655	AKT serine/threonine kinase 1.	Protein-serine/threonine kinase.	0.488