31 items (Rhinopithecus bieti) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2563 aa)
	ENSRBIP00000000510	Uncharacterized protein. (105 aa)
	MSH3	MutS homolog 3. (1195 aa)
	MSH4	MutS homolog 4. (935 aa)
	MSH6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1305 aa)
	RNASEH2A	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (300 aa)
	UPK3B	Uncharacterized protein. (378 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	MLH1	MutL homolog 1. (754 aa)
	MUTYH	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (536 aa)
	MSH5	DNA_MISMATCH_REPAIR_2 domain-containing protein. (778 aa)
	MCM9	Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1140 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	XPC	XPC complex subunit, DNA damage recognition and repair factor. (939 aa)
	RNASEH2B	Uncharacterized protein. (309 aa)
	ENSRBIP00000013617	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (245 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (932 aa)
	TDG	Thymine DNA glycosylase. (397 aa)
	MLH3	MutL homolog 3. (1449 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
	PMS1	PMS1 homolog 1, mismatch repair system component. (933 aa)
	ENSRBIP00000024237	Uncharacterized protein. (283 aa)
	ENSRBIP00000025209	Uncharacterized protein. (99 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	EXO1	Exonuclease 1. (827 aa)
	PMS2	PMS1 homolog 2, mismatch repair system component. (572 aa)
	POLD3	Uncharacterized protein. (454 aa)
	ERCC1	ERCC excision repair 1, endonuclease non-catalytic subunit. (289 aa)
	LIG1	DNA ligase. (928 aa)
	RPA3	Replication protein A3. (121 aa)
	RNASEH2C	Ribonuclease H2 subunit C. (246 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	TP73	ENSRBIP00000007933	ENSRBIP00000017255	Tyrosine-protein kinase.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.623
ENSRBIP00000000510	ENSRBIP00000013617	ENSRBIP00000000510	ENSRBIP00000013617	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.949
ENSRBIP00000000510	ERCC1	ENSRBIP00000000510	ENSRBIP00000041181	Uncharacterized protein.	ERCC excision repair 1, endonuclease non-catalytic subunit.	0.580
ENSRBIP00000000510	EXO1	ENSRBIP00000000510	ENSRBIP00000025464	Uncharacterized protein.	Exonuclease 1.	0.948
ENSRBIP00000000510	LIG1	ENSRBIP00000000510	ENSRBIP00000040555	Uncharacterized protein.	DNA ligase.	0.715
ENSRBIP00000000510	MCM9	ENSRBIP00000000510	ENSRBIP00000007873	Uncharacterized protein.	Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family.	0.619
ENSRBIP00000000510	MLH1	ENSRBIP00000000510	ENSRBIP00000007384	Uncharacterized protein.	MutL homolog 1.	0.976
ENSRBIP00000000510	MLH3	ENSRBIP00000000510	ENSRBIP00000014905	Uncharacterized protein.	MutL homolog 3.	0.887
ENSRBIP00000000510	MSH2	ENSRBIP00000000510	ENSRBIP00000014641	Uncharacterized protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.990
ENSRBIP00000000510	MSH3	ENSRBIP00000000510	ENSRBIP00000001122	Uncharacterized protein.	MutS homolog 3.	0.904
ENSRBIP00000000510	MSH4	ENSRBIP00000000510	ENSRBIP00000002748	Uncharacterized protein.	MutS homolog 4.	0.451
ENSRBIP00000000510	MUTYH	ENSRBIP00000000510	ENSRBIP00000007408	Uncharacterized protein.	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	0.586
ENSRBIP00000000510	PCNA	ENSRBIP00000000510	ENSRBIP00000007375	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.949
ENSRBIP00000000510	PMS1	ENSRBIP00000000510	ENSRBIP00000022736	Uncharacterized protein.	PMS1 homolog 1, mismatch repair system component.	0.929
ENSRBIP00000000510	PMS2	ENSRBIP00000000510	ENSRBIP00000031396	Uncharacterized protein.	PMS1 homolog 2, mismatch repair system component.	0.973
ENSRBIP00000000510	RPA1	ENSRBIP00000000510	ENSRBIP00000025409	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.874
ENSRBIP00000000510	RPA3	ENSRBIP00000000510	ENSRBIP00000033251	Uncharacterized protein.	Replication protein A3.	0.578
ENSRBIP00000013617	ENSRBIP00000000510	ENSRBIP00000013617	ENSRBIP00000000510	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein.	0.949
ENSRBIP00000013617	ENSRBIP00000024237	ENSRBIP00000013617	ENSRBIP00000024237	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein.	0.558
ENSRBIP00000013617	EXO1	ENSRBIP00000013617	ENSRBIP00000025464	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Exonuclease 1.	0.934