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PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa) | ||||
WAC | WW domain containing adaptor with coiled-coil. (626 aa) | ||||
TRIM21 | Tripartite motif containing 21. (475 aa) | ||||
RAG1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa) | ||||
FANCA | FA complementation group A. (1375 aa) | ||||
KDM2B | Lysine demethylase 2B. (1369 aa) | ||||
TRIM56 | Tripartite motif containing 56. (755 aa) | ||||
KLHL22 | Kelch like family member 22. (634 aa) | ||||
ZNF598 | Zinc finger protein 598. (838 aa) | ||||
LOC108544295 | Uncharacterized protein; Belongs to the SKP1 family. (163 aa) | ||||
UBE2W | UBIQUITIN_CONJUGAT_2 domain-containing protein. (209 aa) | ||||
PEX12 | Peroxisomal biogenesis factor 12. (473 aa) | ||||
UBE2O | Ubiquitin conjugating enzyme E2 O. (1324 aa) | ||||
LOC108532799 | FANCA_interact domain-containing protein. (135 aa) | ||||
BRCA2 | Uncharacterized protein. (386 aa) | ||||
ENSRBIP00000039481 | RING-type domain-containing protein. (268 aa) | ||||
TRIM25 | Tripartite motif containing 25. (630 aa) | ||||
CBL | Cbl proto-oncogene. (802 aa) | ||||
PCGF1 | Polycomb group ring finger 1. (259 aa) | ||||
TRIM37 | Tripartite motif containing 37. (951 aa) | ||||
SKP1 | Uncharacterized protein; Belongs to the SKP1 family. (154 aa) | ||||
PCGF5 | Polycomb group ring finger 5. (255 aa) | ||||
PCGF3 | Polycomb group ring finger 3. (242 aa) | ||||
RNF20 | E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa) | ||||
ENSRBIP00000032723 | RAWUL domain-containing protein. (144 aa) | ||||
DTX3L | Deltex E3 ubiquitin ligase 3L. (744 aa) | ||||
TOPORS | TOP1 binding arginine/serine rich protein. (1047 aa) | ||||
FANCB | FA complementation group B. (516 aa) | ||||
ENSRBIP00000039839 | Uncharacterized protein; Belongs to the SKP1 family. (129 aa) | ||||
OBI1 | ORC ubiquitin ligase 1. (716 aa) | ||||
BARD1 | BRCA1 associated RING domain 1. (771 aa) | ||||
TSG101 | Tumor susceptibility 101. (381 aa) | ||||
RBX1 | Ring-box 1. (108 aa) | ||||
RAD18 | RAD18 E3 ubiquitin protein ligase. (494 aa) | ||||
FANCE | FA complementation group E. (536 aa) | ||||
CTR9 | CTR9 homolog, Paf1/RNA polymerase II complex component. (1171 aa) | ||||
FANCC | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (558 aa) | ||||
DTL | Denticleless E3 ubiquitin protein ligase homolog. (730 aa) | ||||
RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (337 aa) | ||||
ENSRBIP00000031768 | Uncharacterized protein. (245 aa) | ||||
KBTBD8 | Kelch repeat and BTB domain containing 8. (601 aa) | ||||
RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa) | ||||
TRIM41 | Tripartite motif containing 41. (612 aa) | ||||
MGRN1 | Mahogunin ring finger 1. (594 aa) | ||||
FAAP100 | FA core complex associated protein 100. (881 aa) | ||||
RYBP | RING1 and YY1 binding protein. (260 aa) | ||||
UBE2T | Ubiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (240 aa) | ||||
ENSRBIP00000027334 | CULLIN_2 domain-containing protein; Belongs to the cullin family. (299 aa) | ||||
LEO1 | LEO1 homolog, Paf1/RNA polymerase II complex component. (666 aa) | ||||
DDB2 | Damage specific DNA binding protein 2. (427 aa) | ||||
LOC108537150 | Uncharacterized protein. (678 aa) | ||||
FANCL | FA complementation group L. (383 aa) | ||||
MARCHF7 | Membrane associated ring-CH-type finger 7. (704 aa) | ||||
PCGF6 | Polycomb group ring finger 6. (350 aa) | ||||
HUWE1 | HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. (4151 aa) | ||||
RNF220 | RNF220 domain-containing protein. (234 aa) | ||||
UBE2E1 | Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa) | ||||
ENSRBIP00000020047 | Uncharacterized protein; Belongs to the SKP1 family. (162 aa) | ||||
RNF2 | Ring finger protein 2. (336 aa) | ||||
DDB1 | Damage specific DNA binding protein 1. (1140 aa) | ||||
UBE2R2 | Ubiquitin conjugating enzyme E2 R2; Belongs to the ubiquitin-conjugating enzyme family. (234 aa) | ||||
UHRF1 | Ubiquitin like with PHD and ring finger domains 1. (859 aa) | ||||
FANCG | FA complementation group G. (622 aa) | ||||
RING1 | Ring finger protein 1. (387 aa) | ||||
KLHL12 | BTB domain-containing protein. (568 aa) | ||||
RNF40 | E3 ubiquitin protein ligase; Belongs to the BRE1 family. (1001 aa) | ||||
ENSRBIP00000016521 | BTB domain-containing protein. (544 aa) | ||||
NEURL1 | Neuralized E3 ubiquitin protein ligase 1. (652 aa) | ||||
ENSRBIP00000015804 | Cullin domain-containing protein; Belongs to the cullin family. (280 aa) | ||||
ZC4H2 | Zinc finger C4H2-type containing. (201 aa) | ||||
CUL1 | Cullin 1; Belongs to the cullin family. (776 aa) | ||||
PCGF2 | Polycomb group ring finger 2. (344 aa) | ||||
CDC73 | Cell division cycle 73. (531 aa) | ||||
FBXL2 | F-box and leucine rich repeat protein 2. (404 aa) | ||||
ATXN7L3 | Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and EN [...] (354 aa) | ||||
BCOR | BCL6 corepressor. (1778 aa) | ||||
CUL3 | Cullin 3; Belongs to the cullin family. (715 aa) |