STRINGSTRING
PRKN PRKN WAC WAC TRIM21 TRIM21 RAG1 RAG1 FANCA FANCA KDM2B KDM2B TRIM56 TRIM56 KLHL22 KLHL22 ZNF598 ZNF598 LOC108544295 LOC108544295 UBE2W UBE2W PEX12 PEX12 UBE2O UBE2O LOC108532799 LOC108532799 BRCA2 BRCA2 ENSRBIP00000039481 ENSRBIP00000039481 TRIM25 TRIM25 CBL CBL PCGF1 PCGF1 TRIM37 TRIM37 SKP1 SKP1 PCGF5 PCGF5 PCGF3 PCGF3 RNF20 RNF20 ENSRBIP00000032723 ENSRBIP00000032723 DTX3L DTX3L TOPORS TOPORS FANCB FANCB ENSRBIP00000039839 ENSRBIP00000039839 OBI1 OBI1 BARD1 BARD1 TSG101 TSG101 RBX1 RBX1 RAD18 RAD18 FANCE FANCE CTR9 CTR9 FANCC FANCC DTL DTL RAD51 RAD51 ENSRBIP00000031768 ENSRBIP00000031768 KBTBD8 KBTBD8 RNF168 RNF168 TRIM41 TRIM41 MGRN1 MGRN1 FAAP100 FAAP100 RYBP RYBP UBE2T UBE2T ENSRBIP00000027334 ENSRBIP00000027334 LEO1 LEO1 DDB2 DDB2 LOC108537150 LOC108537150 FANCL FANCL MARCHF7 MARCHF7 PCGF6 PCGF6 HUWE1 HUWE1 RNF220 RNF220 UBE2E1 UBE2E1 ENSRBIP00000020047 ENSRBIP00000020047 RNF2 RNF2 DDB1 DDB1 UBE2R2 UBE2R2 UHRF1 UHRF1 FANCG FANCG RING1 RING1 KLHL12 KLHL12 RNF40 RNF40 ENSRBIP00000016521 ENSRBIP00000016521 NEURL1 NEURL1 ENSRBIP00000015804 ENSRBIP00000015804 ZC4H2 ZC4H2 CUL1 CUL1 PCGF2 PCGF2 CDC73 CDC73 FBXL2 FBXL2 ATXN7L3 ATXN7L3 BCOR BCOR CUL3 CUL3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
WACWW domain containing adaptor with coiled-coil. (626 aa)
TRIM21Tripartite motif containing 21. (475 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
FANCAFA complementation group A. (1375 aa)
KDM2BLysine demethylase 2B. (1369 aa)
TRIM56Tripartite motif containing 56. (755 aa)
KLHL22Kelch like family member 22. (634 aa)
ZNF598Zinc finger protein 598. (838 aa)
LOC108544295Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
UBE2WUBIQUITIN_CONJUGAT_2 domain-containing protein. (209 aa)
PEX12Peroxisomal biogenesis factor 12. (473 aa)
UBE2OUbiquitin conjugating enzyme E2 O. (1324 aa)
LOC108532799FANCA_interact domain-containing protein. (135 aa)
BRCA2Uncharacterized protein. (386 aa)
ENSRBIP00000039481RING-type domain-containing protein. (268 aa)
TRIM25Tripartite motif containing 25. (630 aa)
CBLCbl proto-oncogene. (802 aa)
PCGF1Polycomb group ring finger 1. (259 aa)
TRIM37Tripartite motif containing 37. (951 aa)
SKP1Uncharacterized protein; Belongs to the SKP1 family. (154 aa)
PCGF5Polycomb group ring finger 5. (255 aa)
PCGF3Polycomb group ring finger 3. (242 aa)
RNF20E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa)
ENSRBIP00000032723RAWUL domain-containing protein. (144 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (744 aa)
TOPORSTOP1 binding arginine/serine rich protein. (1047 aa)
FANCBFA complementation group B. (516 aa)
ENSRBIP00000039839Uncharacterized protein; Belongs to the SKP1 family. (129 aa)
OBI1ORC ubiquitin ligase 1. (716 aa)
BARD1BRCA1 associated RING domain 1. (771 aa)
TSG101Tumor susceptibility 101. (381 aa)
RBX1Ring-box 1. (108 aa)
RAD18RAD18 E3 ubiquitin protein ligase. (494 aa)
FANCEFA complementation group E. (536 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1171 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (558 aa)
DTLDenticleless E3 ubiquitin protein ligase homolog. (730 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (337 aa)
ENSRBIP00000031768Uncharacterized protein. (245 aa)
KBTBD8Kelch repeat and BTB domain containing 8. (601 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa)
TRIM41Tripartite motif containing 41. (612 aa)
MGRN1Mahogunin ring finger 1. (594 aa)
FAAP100FA core complex associated protein 100. (881 aa)
RYBPRING1 and YY1 binding protein. (260 aa)
UBE2TUbiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (240 aa)
ENSRBIP00000027334CULLIN_2 domain-containing protein; Belongs to the cullin family. (299 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (666 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
LOC108537150Uncharacterized protein. (678 aa)
FANCLFA complementation group L. (383 aa)
MARCHF7Membrane associated ring-CH-type finger 7. (704 aa)
PCGF6Polycomb group ring finger 6. (350 aa)
HUWE1HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. (4151 aa)
RNF220RNF220 domain-containing protein. (234 aa)
UBE2E1Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa)
ENSRBIP00000020047Uncharacterized protein; Belongs to the SKP1 family. (162 aa)
RNF2Ring finger protein 2. (336 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
UBE2R2Ubiquitin conjugating enzyme E2 R2; Belongs to the ubiquitin-conjugating enzyme family. (234 aa)
UHRF1Ubiquitin like with PHD and ring finger domains 1. (859 aa)
FANCGFA complementation group G. (622 aa)
RING1Ring finger protein 1. (387 aa)
KLHL12BTB domain-containing protein. (568 aa)
RNF40E3 ubiquitin protein ligase; Belongs to the BRE1 family. (1001 aa)
ENSRBIP00000016521BTB domain-containing protein. (544 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (652 aa)
ENSRBIP00000015804Cullin domain-containing protein; Belongs to the cullin family. (280 aa)
ZC4H2Zinc finger C4H2-type containing. (201 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
CDC73Cell division cycle 73. (531 aa)
FBXL2F-box and leucine rich repeat protein 2. (404 aa)
ATXN7L3Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and EN [...] (354 aa)
BCORBCL6 corepressor. (1778 aa)
CUL3Cullin 3; Belongs to the cullin family. (715 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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