STRINGSTRING
RAD51D RAD51D CHD8 CHD8 HELB HELB SMARCA4 SMARCA4 SMARCA2 SMARCA2 RTEL1 RTEL1 MPHOSPH9 MPHOSPH9 MCM6 MCM6 LOC108520834 LOC108520834 FBH1 FBH1 MCM4 MCM4 CHD6 CHD6 CHD2 CHD2 ERCC6L ERCC6L MCM3 MCM3 SMARCA1 SMARCA1 RAD51B RAD51B ENSRBIP00000024049 ENSRBIP00000024049 SRCAP SRCAP XRCC2 XRCC2 ENSRBIP00000023338 ENSRBIP00000023338 CHD9 CHD9 C11orf80 C11orf80 MCM5 MCM5 ENSRBIP00000022922 ENSRBIP00000022922 RUVBL2 RUVBL2 ERCC6 ERCC6 PMS1 PMS1 NAV2 NAV2 RECQL RECQL MCM2 MCM2 HFM1 HFM1 CHD3 CHD3 RECQL4 RECQL4 RUVBL1 RUVBL1 XRCC5 XRCC5 ENSRBIP00000017801 ENSRBIP00000017801 PIF1 PIF1 MCM7 MCM7 RAD54L2 RAD54L2 CHD5 CHD5 SMC6 SMC6 INO80 INO80 WRN WRN RAD51C RAD51C SPO11 SPO11 SUPV3L1 SUPV3L1 ERCC2 ERCC2 MLH3 MLH3 XRCC3 XRCC3 MSH2 MSH2 WRNIP1 WRNIP1 ENSRBIP00000012004 ENSRBIP00000012004 BLM BLM ENSRBIP00000011440 ENSRBIP00000011440 ENSRBIP00000011182 ENSRBIP00000011182 CDK7 CDK7 ATAD5 ATAD5 ENSRBIP00000009858 ENSRBIP00000009858 ENSRBIP00000009490 ENSRBIP00000009490 TM4SF19 TM4SF19 CECR2 CECR2 TOP2A TOP2A MCM9 MCM9 ERCC3 ERCC3 MSH5 MSH5 BTAF1 BTAF1 MLH1 MLH1 SHPRH SHPRH BRIP1 BRIP1 TOP2B TOP2B POLQ POLQ GTF2F2 GTF2F2 MSH6 MSH6 ERCC6L2 ERCC6L2 MCM8 MCM8 HLTF HLTF UPF1 UPF1 MSH4 MSH4 FANCM FANCM RECQL5 RECQL5 ENSRBIP00000001755 ENSRBIP00000001755 MSH3 MSH3 ENSRBIP00000000510 ENSRBIP00000000510 PMS2 PMS2 RAD51 RAD51 XRCC6 XRCC6 ZRANB3 ZRANB3 SMARCAL1 SMARCAL1 RFC1 RFC1 SETX SETX DDX11 DDX11 C17orf64 C17orf64 HELLS HELLS DHX9 DHX9 DNA2 DNA2 CHD1L CHD1L CHD4 CHD4 HELQ HELQ DQX1 DQX1 SMARCAD1 SMARCAD1 ENSRBIP00000036862 ENSRBIP00000036862 DDX1 DDX1 G3BP1 G3BP1 ASCC3 ASCC3 TTF2 TTF2 CEP41 CEP41 TWNK TWNK RFC3 RFC3 RSF1 RSF1 RAD54L RAD54L RAD17 RAD17 CHD7 CHD7 DMC1 DMC1 SELENOV SELENOV ENSRBIP00000041364 ENSRBIP00000041364 EP400 EP400 IGHMBP2 IGHMBP2 CHD1 CHD1 DHX36 DHX36 SMARCA5 SMARCA5 MYO18A MYO18A
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAD51DRAD51 paralog D. (347 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2535 aa)
HELBDNA helicase B. (1087 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1679 aa)
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1556 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1343 aa)
MPHOSPH9M-phase phosphoprotein 9. (1132 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
LOC108520834Helicase ATP-binding domain-containing protein. (705 aa)
FBH1F-box DNA helicase 1. (1079 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
CHD6BRK domain-containing protein. (1359 aa)
CHD2Uncharacterized protein. (1799 aa)
ERCC6LERCC excision repair 6 like, spindle assembly checkpoint helicase. (1200 aa)
MCM3DNA helicase; Belongs to the MCM family. (828 aa)
SMARCA1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (752 aa)
RAD51BRAD51 paralog B. (426 aa)
ENSRBIP00000024049EP400_N domain-containing protein. (391 aa)
SRCAPUncharacterized protein. (3230 aa)
XRCC2X-ray repair cross complementing 2. (281 aa)
ENSRBIP00000023338Uncharacterized protein. (572 aa)
CHD9Uncharacterized protein. (2416 aa)
C11orf80Chromosome 11 open reading frame 80. (511 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
ENSRBIP00000022922Protein kinase domain-containing protein. (254 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1484 aa)
PMS1PMS1 homolog 1, mismatch repair system component. (933 aa)
NAV2Neuron navigator 2. (2452 aa)
RECQLATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (649 aa)
MCM2DNA helicase; Belongs to the MCM family. (907 aa)
HFM1Helicase ATP-binding domain-containing protein. (471 aa)
CHD3Chromodomain helicase DNA binding protein 3. (2012 aa)
RECQL4RecQ like helicase 4. (1197 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
XRCC5X-ray repair cross complementing 5. (805 aa)
ENSRBIP00000017801Uncharacterized protein. (86 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (641 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
RAD54L2RAD54 like 2. (1467 aa)
CHD5Chromodomain helicase DNA binding protein 5. (1978 aa)
SMC6Structural maintenance of chromosomes 6. (1040 aa)
INO80INO80 complex ATPase subunit. (1555 aa)
WRNWRN RecQ like helicase. (1394 aa)
RAD51CRAD51 paralog C. (376 aa)
SPO11SPO11 initiator of meiotic double stranded breaks. (407 aa)
SUPV3L1Suv3 like RNA helicase. (544 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (675 aa)
MLH3MutL homolog 3. (1449 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (347 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (932 aa)
WRNIP1WRN helicase interacting protein 1. (663 aa)
ENSRBIP00000012004Uncharacterized protein. (450 aa)
BLMBLM RecQ like helicase. (1396 aa)
ENSRBIP00000011440HELICc2 domain-containing protein. (117 aa)
ENSRBIP00000011182Ku domain-containing protein. (328 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
ATAD5ATPase family AAA domain containing 5. (1718 aa)
ENSRBIP00000009858Uncharacterized protein. (392 aa)
ENSRBIP00000009490Uncharacterized protein. (81 aa)
TM4SF19Uncharacterized protein. (295 aa)
CECR2CECR2 histone acetyl-lysine reader. (1419 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1515 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1140 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa)
MSH5DNA_MISMATCH_REPAIR_2 domain-containing protein. (778 aa)
BTAF1B-TFIID TATA-box binding protein associated factor 1. (1857 aa)
MLH1MutL homolog 1. (754 aa)
SHPRHSNF2 histone linker PHD RING helicase. (1682 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1226 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1559 aa)
POLQDNA polymerase theta. (2717 aa)
GTF2F2General transcription factor IIF subunit 2. (232 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1305 aa)
ERCC6L2ERCC excision repair 6 like 2. (691 aa)
MCM8MCM domain-containing protein; Belongs to the MCM family. (880 aa)
HLTFHelicase like transcription factor. (999 aa)
UPF1UPF1 RNA helicase and ATPase. (1068 aa)
MSH4MutS homolog 4. (935 aa)
FANCMFA complementation group M. (2047 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (991 aa)
ENSRBIP00000001755Uncharacterized protein. (218 aa)
MSH3MutS homolog 3. (1195 aa)
ENSRBIP00000000510Uncharacterized protein. (105 aa)
PMS2PMS1 homolog 2, mismatch repair system component. (572 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (337 aa)
XRCC6X-ray repair cross complementing 6. (568 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (998 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (959 aa)
RFC1Replication factor C subunit 1. (1114 aa)
SETXSenataxin. (2655 aa)
DDX11DEAD/H-box helicase 11. (906 aa)
C17orf64Chromosome 17 open reading frame 64. (236 aa)
HELLSHelicase, lymphoid specific. (877 aa)
DHX9DExH-box helicase 9. (1275 aa)
DNA2DNA replication helicase/nuclease 2. (1047 aa)
CHD1LChromodomain helicase DNA binding protein 1 like. (899 aa)
CHD4Uncharacterized protein. (1906 aa)
HELQHelicase, POLQ like. (1101 aa)
DQX1DEAQ-box RNA dependent ATPase 1. (717 aa)
SMARCAD1Uncharacterized protein. (1026 aa)
ENSRBIP00000036862Ku domain-containing protein. (567 aa)
DDX1DEAD-box helicase 1. (734 aa)
G3BP1G3BP stress granule assembly factor 1. (466 aa)
ASCC3Helicase C-terminal domain-containing protein. (665 aa)
TTF2Transcription termination factor 2. (1170 aa)
CEP41Centrosomal protein 41. (373 aa)
TWNKTwinkle mtDNA helicase. (684 aa)
RFC3Replication factor C subunit 3. (356 aa)
RSF1Remodeling and spacing factor 1. (1441 aa)
RAD54LRAD54 like. (747 aa)
RAD17RAD17 checkpoint clamp loader component. (676 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2986 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (376 aa)
SELENOVSelenoprotein V. (327 aa)
ENSRBIP00000041364Ku domain-containing protein. (498 aa)
EP400E1A binding protein p400. (3059 aa)
IGHMBP2Immunoglobulin mu DNA binding protein 2. (985 aa)
CHD1Chromodomain helicase DNA binding protein 1. (1686 aa)
DHX36DEAH-box helicase 36. (971 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1053 aa)
MYO18AMyosin XVIIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2212 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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