Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABRAXAS1 | ATM | ENSRBIP00000027410 | ENSRBIP00000020338 | Abraxas 1, BRCA1 A complex subunit. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.612 |
| ABRAXAS1 | BABAM1 | ENSRBIP00000027410 | ENSRBIP00000040844 | Abraxas 1, BRCA1 A complex subunit. | BRISC and BRCA1 A complex member 1. | 0.999 |
| ABRAXAS1 | BABAM2 | ENSRBIP00000027410 | ENSRBIP00000018048 | Abraxas 1, BRCA1 A complex subunit. | BRISC and BRCA1 A complex member 2. | 0.996 |
| ABRAXAS1 | BARD1 | ENSRBIP00000027410 | ENSRBIP00000040308 | Abraxas 1, BRCA1 A complex subunit. | BRCA1 associated RING domain 1. | 0.995 |
| ABRAXAS1 | BRCA1 | ENSRBIP00000027410 | ENSRBIP00000041182 | Abraxas 1, BRCA1 A complex subunit. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.998 |
| ABRAXAS1 | BRCC3 | ENSRBIP00000027410 | ENSRBIP00000035554 | Abraxas 1, BRCA1 A complex subunit. | MPN domain-containing protein. | 0.981 |
| ABRAXAS1 | CHEK2 | ENSRBIP00000027410 | ENSRBIP00000014351 | Abraxas 1, BRCA1 A complex subunit. | Checkpoint kinase 2. | 0.577 |
| ABRAXAS1 | ENSRBIP00000037358 | ENSRBIP00000027410 | ENSRBIP00000037358 | Abraxas 1, BRCA1 A complex subunit. | DUF1725 domain-containing protein. | 0.971 |
| ABRAXAS1 | LOC108538182 | ENSRBIP00000027410 | ENSRBIP00000010274 | Abraxas 1, BRCA1 A complex subunit. | MPN domain-containing protein. | 0.972 |
| ABRAXAS1 | NABP2 | ENSRBIP00000027410 | ENSRBIP00000030765 | Abraxas 1, BRCA1 A complex subunit. | Nucleic acid binding protein 2. | 0.450 |
| ABRAXAS1 | PAXIP1 | ENSRBIP00000027410 | ENSRBIP00000042085 | Abraxas 1, BRCA1 A complex subunit. | PAX interacting protein 1. | 0.551 |
| ABRAXAS1 | RNF168 | ENSRBIP00000027410 | ENSRBIP00000030472 | Abraxas 1, BRCA1 A complex subunit. | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | 0.719 |
| ABRAXAS1 | RNF8 | ENSRBIP00000027410 | ENSRBIP00000004033 | Abraxas 1, BRCA1 A complex subunit. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.626 |
| ABRAXAS1 | TP53BP1 | ENSRBIP00000027410 | ENSRBIP00000016536 | Abraxas 1, BRCA1 A complex subunit. | Tumor protein p53 binding protein 1. | 0.601 |
| ABRAXAS1 | UIMC1 | ENSRBIP00000027410 | ENSRBIP00000032829 | Abraxas 1, BRCA1 A complex subunit. | Ubiquitin interaction motif containing 1. | 0.996 |
| ATM | ABRAXAS1 | ENSRBIP00000020338 | ENSRBIP00000027410 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Abraxas 1, BRCA1 A complex subunit. | 0.612 |
| ATM | ATR | ENSRBIP00000020338 | ENSRBIP00000027292 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | 0.999 |
| ATM | BABAM1 | ENSRBIP00000020338 | ENSRBIP00000040844 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | BRISC and BRCA1 A complex member 1. | 0.614 |
| ATM | BABAM2 | ENSRBIP00000020338 | ENSRBIP00000018048 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | BRISC and BRCA1 A complex member 2. | 0.676 |
| ATM | BARD1 | ENSRBIP00000020338 | ENSRBIP00000040308 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | BRCA1 associated RING domain 1. | 0.985 |
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