STRINGSTRING
VWA5B1 VWA5B1 NEBL NEBL MYH7 MYH7 BMP2 BMP2 IFRD1 IFRD1 CACNA1G CACNA1G MAML1 MAML1 BMP7 BMP7 SHOX2 SHOX2 ENSRBIP00000042195 ENSRBIP00000042195 NPPA NPPA WNT2 WNT2 NEB NEB HEG1 HEG1 WNT5A WNT5A ENSRBIP00000040815 ENSRBIP00000040815 SGCD SGCD ADRA1A ADRA1A CXADR CXADR CHD7 CHD7 FHL2 FHL2 SGCG SGCG MYH11 MYH11 GATA5 GATA5 BMP4 BMP4 MYL7 MYL7 LMNA LMNA SGCB SGCB ZFPM1 ZFPM1 ALPK2 ALPK2 NOTCH2 NOTCH2 NDRG4 NDRG4 SAV1 SAV1 ARID2 ARID2 NKX2-6 NKX2-6 DSG2 DSG2 PTEN PTEN PLEC PLEC ADAMTS9 ADAMTS9 MAPK11 MAPK11 ENG ENG TGFBR1 TGFBR1 PKP2 PKP2 PROX1 PROX1 GATA4 GATA4 MYBPC3 MYBPC3 MEF2C MEF2C DSP DSP TGFBR3 TGFBR3 TNNC1 TNNC1 WNT3A WNT3A XIRP2 XIRP2 NRG1 NRG1 WT1 WT1 AKAP13 AKAP13 ASB2 ASB2 MAP2K4 MAP2K4 FGF9 FGF9 FOXH1 FOXH1 SORBS2 SORBS2 ACTN2 ACTN2 C10orf113 C10orf113 SEMA3C SEMA3C VWA5A VWA5A ENSRBIP00000028070 ENSRBIP00000028070 SMAD7 SMAD7 TTN TTN NPRL3 NPRL3 PRMT1 PRMT1 BMP5 BMP5 MYOCD MYOCD WNT8A WNT8A ENSRBIP00000025903 ENSRBIP00000025903 SGCZ SGCZ MYLK2 MYLK2 TSC1 TSC1 TNNT2 TNNT2 OBSL1 OBSL1 MYL3 MYL3 NOTCH1 NOTCH1 TAZ TAZ TBX2 TBX2 HEY2 HEY2 TENM4 TENM4 COL11A1 COL11A1 TBX3 TBX3 POU4F1 POU4F1 ENSRBIP00000019241 ENSRBIP00000019241 TBX5 TBX5 SMAD4 SMAD4 MYL2 MYL2 BVES BVES PTCD2 PTCD2 NRAP NRAP TBX18 TBX18 CSRP3 CSRP3 SMAD1 SMAD1 DLL4 DLL4 ALDH1A2 ALDH1A2 MESP1 MESP1 ENSRBIP00000016494 ENSRBIP00000016494 KDM6B KDM6B NPPB NPPB VWA5B2 VWA5B2 LOC108520322 LOC108520322 PGM5 PGM5 HNRNPU HNRNPU TBX20 TBX20 ZFPM2 ZFPM2 BMPR1A BMPR1A IFRD2 IFRD2 PDGFRB PDGFRB MED1 MED1 FGFR2 FGFR2 EYA2 EYA2 HAND1 HAND1 ZIC3 ZIC3 SCN5A SCN5A MYL10 MYL10 EDNRA EDNRA BMP10 BMP10 RARA RARA MEF2A MEF2A RARB RARB SIRT6 SIRT6 SHH SHH LRP2 LRP2 TCAP TCAP TNNI1 TNNI1 HOPX HOPX PPP1R13L PPP1R13L CBY1 CBY1 MSC MSC RYR2 RYR2 EGLN1 EGLN1 PLN PLN ACVR1 ACVR1 ISL1 ISL1 TGFB1 TGFB1 JARID2 JARID2 ALPK3 ALPK3 IRX3 IRX3 GJC1 GJC1 PDLIM5 PDLIM5 ANKRD1 ANKRD1 SLC9A1 SLC9A1 ZMPSTE24 ZMPSTE24 HEY1 HEY1 MTOR MTOR GJA5 GJA5 TNNI3 TNNI3 SLC8A1 SLC8A1 EYA1 EYA1 IFT20 IFT20 MYO18B MYO18B NOG NOG TGFB2 TGFB2 S1PR1 S1PR1 LOC108517114 LOC108517114 ATG5 ATG5 DIPK2A DIPK2A CAV3 CAV3 NKX2-5 NKX2-5 LRRC10 LRRC10 FHOD3 FHOD3 ENSRBIP00000000203 ENSRBIP00000000203 SRF SRF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VWA5B1Von Willebrand factor A domain containing 5B1. (1215 aa)
NEBLNebulette. (979 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa)
BMP2Bone morphogenetic protein 2. (321 aa)
IFRD1Interferon related developmental regulator 1. (451 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2377 aa)
MAML1Mastermind like transcriptional coactivator 1. (961 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SHOX2Short stature homeobox 2. (355 aa)
ENSRBIP00000042195Uncharacterized protein. (122 aa)
NPPANatriuretic peptide A. (142 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
NEBNebulin. (7505 aa)
HEG1Heart development protein with EGF like domains 1. (1347 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ENSRBIP00000040815Uncharacterized protein. (5512 aa)
SGCDUncharacterized protein. (102 aa)
ADRA1AAdrenoceptor alpha 1A. (455 aa)
CXADRCXADR Ig-like cell adhesion molecule. (365 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2986 aa)
FHL2Four and a half LIM domains 2. (389 aa)
SGCGSarcoglycan gamma. (215 aa)
MYH11Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2018 aa)
GATA5GATA binding protein 5. (263 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
MYL7Myosin light chain 7. (199 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (728 aa)
SGCBSarcoglycan beta. (313 aa)
ZFPM1Uncharacterized protein. (143 aa)
ALPK2Alpha kinase 2. (2166 aa)
NOTCH2Notch receptor 2. (2532 aa)
NDRG4NDRG family member 4. (391 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
ARID2AT-rich interaction domain 2. (1830 aa)
NKX2-6NK2 homeobox 6. (301 aa)
DSG2Desmoglein 2. (1118 aa)
PTENUncharacterized protein. (555 aa)
PLECPlectin. (4578 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif 9. (1916 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
ENGEndoglin. (607 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
PKP2Plakophilin 2. (882 aa)
PROX1Prospero homeobox 1. (737 aa)
GATA4GATA binding protein 4. (432 aa)
MYBPC3Myosin binding protein C, cardiac. (1195 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
DSPDesmoplakin. (2857 aa)
TGFBR3Transforming growth factor beta receptor 3. (861 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
XIRP2Uncharacterized protein. (962 aa)
NRG1Neuregulin 1. (713 aa)
WT1WT1 transcription factor. (515 aa)
AKAP13A-kinase anchoring protein 13. (2816 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (714 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (408 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FOXH1Forkhead box H1. (366 aa)
SORBS2Sorbin and SH3 domain containing 2. (1200 aa)
ACTN2Actinin alpha 2. (857 aa)
C10orf113Chromosome 10 open reading frame 113. (152 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
VWA5AVon Willebrand factor A domain containing 5A. (790 aa)
ENSRBIP00000028070Uncharacterized protein. (490 aa)
SMAD7Mothers against decapentaplegic homolog. (431 aa)
TTNUncharacterized protein. (563 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (562 aa)
PRMT1Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
BMP5TGF_BETA_2 domain-containing protein. (154 aa)
MYOCDMyocardin. (832 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ENSRBIP00000025903Uncharacterized protein. (1795 aa)
SGCZSarcoglycan zeta. (170 aa)
MYLK2Myosin light chain kinase 2. (603 aa)
TSC1TSC complex subunit 1. (1164 aa)
TNNT2Troponin T2, cardiac type. (302 aa)
OBSL1Obscurin like 1. (1896 aa)
MYL3Myosin light chain 3. (213 aa)
NOTCH1Notch receptor 1. (2438 aa)
TAZTafazzin family protein; Some isoforms may be involved in cardiolipin metabolism. (295 aa)
TBX2T-box transcription factor 2. (686 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
TENM4Teneurin transmembrane protein 4. (2848 aa)
COL11A1Collagen type XI alpha 1 chain. (1745 aa)
TBX3T-box transcription factor 3. (743 aa)
POU4F1POU domain protein. (424 aa)
ENSRBIP00000019241Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (458 aa)
TBX5T-box transcription factor 5. (518 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
MYL2Myosin light chain 2. (166 aa)
BVESBlood vessel epicardial substance. (360 aa)
PTCD2Pentatricopeptide repeat domain 2. (369 aa)
NRAPNebulin related anchoring protein. (1731 aa)
TBX18T-box transcription factor 18. (607 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (272 aa)
ENSRBIP00000016494Protein kinase domain-containing protein. (253 aa)
KDM6BLysine demethylase 6B. (1591 aa)
NPPBNatriuretic peptide B. (124 aa)
VWA5B2Von Willebrand factor A domain containing 5B2. (1023 aa)
LOC108520322Fork-head domain-containing protein. (198 aa)
PGM5Phosphoglucomutase 5; Belongs to the phosphohexose mutase family. (567 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (793 aa)
TBX20T-box transcription factor 20. (447 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1257 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
IFRD2Uncharacterized protein. (510 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1102 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1547 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (530 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
ZIC3Zic family member 3. (466 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
MYL10Myosin light chain 10. (225 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (426 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
RARARetinoic acid receptor alpha. (478 aa)
MEF2AMyocyte enhancer factor 2A. (511 aa)
RARBRetinoic acid receptor beta. (448 aa)
SIRT6Sirtuin 6. (355 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (427 aa)
LRP2LDL receptor related protein 2. (4655 aa)
TCAPTitin-cap. (167 aa)
TNNI1Troponin I1, slow skeletal type. (187 aa)
HOPXHOP homeobox. (109 aa)
PPP1R13LUncharacterized protein. (389 aa)
CBY1Chibby family member 1, beta catenin antagonist. (169 aa)
MSCMusculin. (206 aa)
RYR2Ryanodine receptor 2. (4866 aa)
EGLN1Egl-9 family hypoxia inducible factor 1. (409 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (511 aa)
ISL1ISL LIM homeobox 1. (349 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1246 aa)
ALPK3Alpha kinase 3. (1860 aa)
IRX3Iroquois homeobox 3. (502 aa)
GJC1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa)
PDLIM5PDZ and LIM domain 5. (588 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (441 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2527 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
TNNI3Troponin I3, cardiac type. (210 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
IFT20Intraflagellar transport 20. (158 aa)
MYO18BMyosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2562 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (231 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
LOC108517114Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
DIPK2ADivergent protein kinase domain 2A. (430 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
NKX2-5NK2 homeobox 5. (325 aa)
LRRC10Leucine rich repeat containing 10. (279 aa)
FHOD3Formin homology 2 domain containing 3. (1504 aa)
ENSRBIP00000000203Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (250 aa)
SRFSerum response factor. (508 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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