STRINGSTRING
RNF6 RNF6 UBE2I UBE2I ENSRBIP00000003466 ENSRBIP00000003466 ENSRBIP00000003512 ENSRBIP00000003512 ENSRBIP00000000016 ENSRBIP00000000016 TP53INP2 TP53INP2 NSMCE2 NSMCE2 BASP1 BASP1 NFE2 NFE2 TCF7L2 TCF7L2 RPAIN RPAIN RB1 RB1 SUMO2 SUMO2 CHD3 CHD3 TENM2 TENM2 CASP8AP2 CASP8AP2 EIF3E-2 EIF3E-2 LOC108525824 LOC108525824 IKBKE IKBKE GCNA GCNA ENSRBIP00000004541 ENSRBIP00000004541 AKAP8L AKAP8L MTOR MTOR ENSRBIP00000004777 ENSRBIP00000004777 TRIM27 TRIM27 CIART CIART RNF4 RNF4 HIRA HIRA HIPK1 HIPK1 CHFR CHFR HIPK3 HIPK3 SIRT1 SIRT1 ENSRBIP00000010478 ENSRBIP00000010478 BLM BLM ENSRBIP00000011695 ENSRBIP00000011695 RDM1 RDM1 RGS14 RGS14 ZBED1 ZBED1 SP3 SP3 DAXX DAXX ENSRBIP00000013673 ENSRBIP00000013673 MORC3 MORC3 TOP3A TOP3A CHEK2 CHEK2 TDG TDG ENSRBIP00000015800 ENSRBIP00000015800 SMC6 SMC6 TERT TERT PATL1 PATL1 PPARGC1A PPARGC1A ARNTL ARNTL TRIM8 TRIM8 KLHL20 KLHL20 SUMO3 SUMO3 N4BP1 N4BP1 UBN1 UBN1 SKI SKI KAT6A KAT6A ENSRBIP00000021908 ENSRBIP00000021908 EIF4ENIF1 EIF4ENIF1 NR2C1 NR2C1 ENSRBIP00000019981 ENSRBIP00000019981 RNF111 RNF111 ELF4 ELF4 HSF1 HSF1 SPTBN4 SPTBN4 MAX MAX ENSRBIP00000039712 ENSRBIP00000039712 TOPBP1 TOPBP1 ENSRBIP00000039245 ENSRBIP00000039245 EIF3E EIF3E SATB1 SATB1 MAPK7 MAPK7 PIAS4 PIAS4 DAPK3 DAPK3 MLIP MLIP LRCH4 LRCH4 ISG20 ISG20 PML PML PTEN PTEN SQSTM1 SQSTM1 HIPK2 HIPK2 ZNF451 ZNF451 TOPORS TOPORS RAD51 RAD51 SMC5 SMC5 ENSRBIP00000030956 ENSRBIP00000030956 ANKRD2 ANKRD2 CDK9 CDK9 PIAS2 PIAS2 TP53 TP53 MKNK2 MKNK2 ATR ATR USP7 USP7 CIITA CIITA RFWD3 RFWD3 TP53INP1 TP53INP1 TDP2 TDP2 WDFY3 WDFY3 NBN NBN RPA1 RPA1 PARK7 PARK7 SP100 SP100 LOC108537150 LOC108537150 ZMYM2 ZMYM2 PIAS1 PIAS1 ENSRBIP00000022924 ENSRBIP00000022924 ZBTB16 ZBTB16
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RNF6Ring finger protein 6. (701 aa)
UBE2IUbiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (231 aa)
ENSRBIP00000003466Ubiquitin-like domain-containing protein. (128 aa)
ENSRBIP00000003512Small ubiquitin-related modifier. (95 aa)
ENSRBIP00000000016Rad60-SLD domain-containing protein. (55 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (220 aa)
NSMCE2SP-RING-type domain-containing protein. (246 aa)
BASP1Brain abundant membrane attached signal protein 1. (186 aa)
NFE2Nuclear factor, erythroid 2. (373 aa)
TCF7L2HMG box domain-containing protein. (376 aa)
RPAINRPA interacting protein. (219 aa)
RB1RB transcriptional corepressor 1. (815 aa)
SUMO2Ubiquitin-like domain-containing protein. (80 aa)
CHD3Chromodomain helicase DNA binding protein 3. (2012 aa)
TENM2Teneurin transmembrane protein 2. (2602 aa)
CASP8AP2Caspase 8 associated protein 2. (1939 aa)
EIF3E-2Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (418 aa)
LOC108525824Uncharacterized protein. (121 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
GCNAGerm cell nuclear acidic peptidase. (515 aa)
ENSRBIP00000004541Ubiquitin-like domain-containing protein. (62 aa)
AKAP8LA-kinase anchoring protein 8 like; Belongs to the AKAP95 family. (624 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2527 aa)
ENSRBIP00000004777Rad60-SLD domain-containing protein. (51 aa)
TRIM27Tripartite motif containing 27. (513 aa)
CIARTCircadian associated repressor of transcription. (385 aa)
RNF4Ring finger protein 4. (190 aa)
HIRAProtein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (1017 aa)
HIPK1Homeodomain interacting protein kinase 1. (1417 aa)
CHFRCheckpoint with forkhead and ring finger domains. (675 aa)
HIPK3Homeodomain interacting protein kinase 3. (1215 aa)
SIRT1Sirtuin 1. (731 aa)
ENSRBIP00000010478SP-RING-type domain-containing protein. (216 aa)
BLMBLM RecQ like helicase. (1396 aa)
ENSRBIP00000011695Small ubiquitin-related modifier. (101 aa)
RDM1RAD52 motif containing 1. (284 aa)
RGS14Regulator of G protein signaling 14. (610 aa)
ZBED1Zinc finger BED-type containing 1. (694 aa)
SP3Sp3 transcription factor. (775 aa)
DAXXDeath domain associated protein. (740 aa)
ENSRBIP00000013673Ubiquitin-like domain-containing protein. (132 aa)
MORC3MORC family CW-type zinc finger 3. (928 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa)
CHEK2Checkpoint kinase 2. (589 aa)
TDGThymine DNA glycosylase. (397 aa)
ENSRBIP00000015800Ubiquitin-like domain-containing protein. (132 aa)
SMC6Structural maintenance of chromosomes 6. (1040 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1167 aa)
PATL1PAT1 homolog 1, processing body mRNA decay factor. (783 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (594 aa)
TRIM8Tripartite motif containing 8. (551 aa)
KLHL20Kelch like family member 20. (609 aa)
SUMO3Small ubiquitin-related modifier. (97 aa)
N4BP1NEDD4 binding protein 1. (895 aa)
UBN1Ubinuclein 1. (1122 aa)
SKISKI proto-oncogene. (637 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1703 aa)
ENSRBIP00000021908Uncharacterized protein. (91 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E nuclear import factor 1. (985 aa)
NR2C1Nuclear receptor subfamily 2 group C member 1. (604 aa)
ENSRBIP00000019981Rad60-SLD domain-containing protein. (81 aa)
RNF111Ring finger protein 111. (994 aa)
ELF4E74 like ETS transcription factor 4. (662 aa)
HSF1Heat shock transcription factor 1. (489 aa)
SPTBN4Spectrin beta chain; Belongs to the spectrin family. (2534 aa)
MAXMYC associated factor X. (162 aa)
ENSRBIP00000039712Uncharacterized protein. (320 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1527 aa)
ENSRBIP00000039245Ubiquitin-like domain-containing protein. (84 aa)
EIF3EEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (456 aa)
SATB1DNA-binding protein SATB. (795 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
PIAS4Protein inhibitor of activated STAT 4. (508 aa)
DAPK3Death associated protein kinase 3. (365 aa)
MLIPMuscular LMNA interacting protein. (981 aa)
LRCH4Leucine rich repeats and calponin homology domain containing 4. (683 aa)
ISG20Interferon stimulated exonuclease gene 20. (181 aa)
PMLPromyelocytic leukemia. (932 aa)
PTENUncharacterized protein. (555 aa)
SQSTM1Sequestosome 1. (451 aa)
HIPK2Homeodomain interacting protein kinase 2. (1209 aa)
ZNF451Zinc finger protein 451. (1061 aa)
TOPORSTOP1 binding arginine/serine rich protein. (1047 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (337 aa)
SMC5Structural maintenance of chromosomes 5. (1054 aa)
ENSRBIP00000030956Small ubiquitin-related modifier. (123 aa)
ANKRD2Ankyrin repeat domain 2. (237 aa)
CDK9Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
PIAS2Protein inhibitor of activated STAT 2. (620 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (465 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2578 aa)
USP7Uncharacterized protein; Belongs to the peptidase C19 family. (1105 aa)
CIITAClass II major histocompatibility complex transactivator. (1125 aa)
RFWD3Ring finger and WD repeat domain 3. (773 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (241 aa)
TDP2Tyrosyl-DNA phosphodiesterase 2. (358 aa)
WDFY3WD repeat and FYVE domain containing 3. (3516 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (752 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
PARK7Parkinsonism associated deglycase. (191 aa)
SP100SP100 nuclear antigen. (823 aa)
LOC108537150Uncharacterized protein. (678 aa)
ZMYM2Zinc finger MYM-type containing 2. (1362 aa)
PIAS1Protein inhibitor of activated STAT 1. (653 aa)
ENSRBIP00000022924Uncharacterized protein. (571 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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