STRINGSTRING
SFRP4 SFRP4 SFRP2 SFRP2 SCUBE3 SCUBE3 SMURF2 SMURF2 FSTL3 FSTL3 CHRD CHRD SKOR1 SKOR1 ABL1 ABL1 CHRDL2 CHRDL2 KIAA1324L KIAA1324L HTRA3 HTRA3 ACVRL1 ACVRL1 SULF1 SULF1 LRP2 LRP2 CHRDL1 CHRDL1 CER1 CER1 ENSRBIP00000011698 ENSRBIP00000011698 SMAD2 SMAD2 BMPR2 BMPR2 HJV HJV LEMD2 LEMD2 ITGA3 ITGA3 TBX20 TBX20 SFRP1 SFRP1 CRIM1 CRIM1 GDF5 GDF5 SMAD4 SMAD4 GDF3 GDF3 SFRP5 SFRP5 BMPER BMPER NUMA1 NUMA1 BAMBI BAMBI DLX1 DLX1 SKI SKI NOTCH1 NOTCH1 SMURF1 SMURF1 FST FST PPM1A PPM1A CTDSPL2 CTDSPL2 DKK1 DKK1 VWC2L VWC2L SOST SOST HES5 HES5 TMPRSS6 TMPRSS6 SPART SPART GDF2 GDF2 HTRA1 HTRA1 RGMA RGMA SMAD7 SMAD7 PCSK6 PCSK6 CCN1 CCN1 FKBP8 FKBP8 SMAD6 SMAD6 TWSG1 TWSG1 CRB2 CRB2 HIPK2 HIPK2 ZNF423 ZNF423 TFAP2B TFAP2B WNT1 WNT1 VWC2 VWC2 GATA4 GATA4 CDH5 CDH5 ENG ENG NOTCH2 NOTCH2 LEMD3 LEMD3 TNFAIP6 TNFAIP6 FBXL15 FBXL15 DAND5 DAND5 ENSRBIP00000037879 ENSRBIP00000037879 SORL1 SORL1 NEO1 NEO1 BMP4 BMP4 WNT5A WNT5A SKOR2 SKOR2 FBN1 FBN1 TRIM33 TRIM33 KDR KDR UBE2O UBE2O GREM2 GREM2 NOG NOG MSX1 MSX1 NBL1 NBL1 SOSTDC1 SOSTDC1 RNF165 RNF165 PELO PELO HOXA13 HOXA13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SFRP4Secreted frizzled related protein 4. (368 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
SCUBE3Signal peptide, CUB domain and EGF like domain containing 3. (993 aa)
SMURF2SMAD specific E3 ubiquitin protein ligase 2. (719 aa)
FSTL3Follistatin like 3. (263 aa)
CHRDChordin. (906 aa)
SKOR1SKI family transcriptional corepressor 1. (956 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
CHRDL2Chordin like 2. (452 aa)
KIAA1324LKIAA1324 like. (1016 aa)
HTRA3HtrA serine peptidase 3. (386 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (872 aa)
LRP2LDL receptor related protein 2. (4655 aa)
CHRDL1Chordin like 1. (458 aa)
CER1Cerberus 1, DAN family BMP antagonist. (267 aa)
ENSRBIP00000011698Uncharacterized protein. (103 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
HJVHemojuvelin BMP co-receptor. (425 aa)
LEMD2LEM domain containing 2. (437 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1087 aa)
TBX20T-box transcription factor 20. (447 aa)
SFRP1Secreted frizzled related protein 1. (313 aa)
CRIM1Cysteine rich transmembrane BMP regulator 1. (1041 aa)
GDF5Growth differentiation factor 5. (499 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GDF3Growth differentiation factor 3. (364 aa)
SFRP5Secreted frizzled related protein 5. (315 aa)
BMPERBMP binding endothelial regulator. (685 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2118 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
DLX1Distal-less homeobox 1. (255 aa)
SKISKI proto-oncogene. (637 aa)
NOTCH1Notch receptor 1. (2438 aa)
SMURF1SMAD specific E3 ubiquitin protein ligase 1. (704 aa)
FSTFollistatin. (333 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
CTDSPL2CTD small phosphatase like 2. (465 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
VWC2LVon Willebrand factor C domain containing 2 like. (222 aa)
SOSTSclerostin. (213 aa)
HES5Hes family bHLH transcription factor 5. (152 aa)
TMPRSS6Transmembrane serine protease 6; Belongs to the peptidase S1 family. (823 aa)
SPARTSpartin. (666 aa)
GDF2Growth differentiation factor 2. (429 aa)
HTRA1HtrA serine peptidase 1. (451 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (458 aa)
SMAD7Mothers against decapentaplegic homolog. (431 aa)
PCSK6Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (921 aa)
CCN1Cellular communication network factor 1. (381 aa)
FKBP8Peptidylprolyl isomerase. (431 aa)
SMAD6Mothers against decapentaplegic homolog. (452 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
CRB2Crumbs cell polarity complex component 2. (1108 aa)
HIPK2Homeodomain interacting protein kinase 2. (1209 aa)
ZNF423Zinc finger protein 423. (1233 aa)
TFAP2BTranscription factor AP-2 beta. (442 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
VWC2Von Willebrand factor C domain containing 2. (325 aa)
GATA4GATA binding protein 4. (432 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (788 aa)
ENGEndoglin. (607 aa)
NOTCH2Notch receptor 2. (2532 aa)
LEMD3LEM domain containing 3. (911 aa)
TNFAIP6TNF alpha induced protein 6. (226 aa)
FBXL15F-box and leucine rich repeat protein 15. (300 aa)
DAND5DAN domain BMP antagonist family member 5. (189 aa)
ENSRBIP00000037879PPM-type phosphatase domain-containing protein. (342 aa)
SORL1Sortilin related receptor 1. (2209 aa)
NEO1Neogenin 1. (1416 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
SKOR2SKI family transcriptional corepressor 2. (964 aa)
FBN1Fibrillin 1. (2871 aa)
TRIM33Tripartite motif containing 33. (1123 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
UBE2OUbiquitin conjugating enzyme E2 O. (1324 aa)
GREM2Gremlin. (168 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (231 aa)
MSX1Msh homeobox 1. (303 aa)
NBL1NBL1, DAN family BMP antagonist. (193 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
RNF165Ring finger protein 165. (384 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
HOXA13Homeobox domain-containing protein. (214 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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