STRINGSTRING
LOC108521908 LOC108521908 ENSRBIP00000002140 ENSRBIP00000002140 ADAM22 ADAM22 SLITRK1 SLITRK1 NPC1 NPC1 DRD3 DRD3 NRXN1 NRXN1 EFNB3 EFNB3 ZMPSTE24 ZMPSTE24 NTF4 NTF4 NLGN3 NLGN3 CHRNB1 CHRNB1 ENSRBIP00000006659 ENSRBIP00000006659 HOMER1 HOMER1 PBX3 PBX3 PRKN PRKN NR4A2 NR4A2 PPARA PPARA CHRNB4 CHRNB4 DRD2 DRD2 EN1 EN1 RNF180 RNF180 PREX2 PREX2 GHSR GHSR MAFG MAFG CTNS CTNS FOXA2 FOXA2 PAX5 PAX5 GIGYF2 GIGYF2 INPP5F INPP5F SLITRK5 SLITRK5 GRM2 GRM2 CHRNA5 CHRNA5 HOXD10 HOXD10 DMRT3 DMRT3 SLC1A2 SLC1A2 NCSTN NCSTN NTAN1 NTAN1 CACNB4 CACNB4 GLRA1 GLRA1 CSTB CSTB ENSRBIP00000016831 ENSRBIP00000016831 SCN1A SCN1A NRXN3 NRXN3 KLHL5 KLHL5 ABHD12 ABHD12 SHANK1 SHANK1 SEZ6 SEZ6 TMOD1 TMOD1 CNP CNP EPHA4 EPHA4 NTSR1 NTSR1 BBS1 BBS1 TRH TRH ATP6V1B1 ATP6V1B1 CNTN2 CNTN2 SLC1A1 SLC1A1 HOXD9 HOXD9 LOC108521200 LOC108521200 PPT1 PPT1 TSC1 TSC1 ALK ALK HDAC2 HDAC2 CDK5 CDK5 PARK7 PARK7 LOC108515161 LOC108515161 HTRA2 HTRA2 FADD FADD CNTNAP2 CNTNAP2 UNC79 UNC79 HEXA HEXA FXN FXN PPP1R1B PPP1R1B BBS4 BBS4 ENSRBIP00000028360 ENSRBIP00000028360 LOC108530786 LOC108530786 OTOG OTOG GHRL GHRL HOMER2 HOMER2 ENSRBIP00000030690 ENSRBIP00000030690 CHRNB2 CHRNB2 SHANK3 SHANK3 ZIC1 ZIC1 NLGN2 NLGN2 CRHBP CRHBP ENSRBIP00000031784 ENSRBIP00000031784 OPRM1 OPRM1 EHMT2 EHMT2 DBH DBH GIP GIP BBS2 BBS2 OXR1 OXR1 SHANK2 SHANK2 HIPK2 HIPK2 EPS8 EPS8 SPTBN2 SPTBN2 TSHR TSHR CXCL12 CXCL12 CHRNA4 CHRNA4 ZFHX2 ZFHX2 BTBD9 BTBD9 PTEN PTEN GLRB GLRB CRHR1 CRHR1 SEPTIN5 SEPTIN5 PAFAH1B1 PAFAH1B1 GRIN2D GRIN2D FGF12 FGF12 PUM1 PUM1 ABAT ABAT APP APP SNCG SNCG AGTPBP1 AGTPBP1 MECP2 MECP2 PMP22 PMP22 CCND2 CCND2 HOXB8 HOXB8 CHRNA3 CHRNA3 CHD7 CHD7 SLC7A11 SLC7A11 SDK1 SDK1 LEP LEP PCDH17 PCDH17 SPTBN4 SPTBN4 DMBX1 DMBX1 PCDH15 PCDH15 SEZ6L2 SEZ6L2 LGI4 LGI4 OPRD1 OPRD1 CLN8 CLN8 NRXN2 NRXN2 KALRN KALRN AGRP AGRP CARTPT CARTPT SLITRK6 SLITRK6 CHL1 CHL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC108521908Cystatin domain-containing protein; Belongs to the cystatin family. (98 aa)
ENSRBIP00000002140CUB domain-containing protein. (365 aa)
ADAM22ADAM metallopeptidase domain 22. (935 aa)
SLITRK1SLIT and NTRK like family member 1. (696 aa)
NPC1NPC intracellular cholesterol transporter 1. (1277 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (400 aa)
NRXN1Uncharacterized protein. (879 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (340 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (441 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
NLGN3Neuroligin 3. (826 aa)
CHRNB1Cholinergic receptor nicotinic beta 1 subunit. (501 aa)
ENSRBIP00000006659Protein kinase domain-containing protein. (275 aa)
HOMER1Homer scaffold protein 1. (374 aa)
PBX3PBX homeobox 3. (434 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit. (492 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
EN1Homeobox protein engrailed-like. (374 aa)
RNF180Uncharacterized protein. (416 aa)
PREX2Uncharacterized protein. (1357 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
MAFGMAF bZIP transcription factor G. (162 aa)
CTNSCystinosin, lysosomal cystine transporter. (400 aa)
FOXA2Forkhead box A2. (463 aa)
PAX5Paired box 5. (391 aa)
GIGYF2GRB10 interacting GYF protein 2. (1276 aa)
INPP5FInositol polyphosphate-5-phosphatase F. (1126 aa)
SLITRK5SLIT and NTRK like family member 5. (959 aa)
GRM2Glutamate metabotropic receptor 2. (872 aa)
CHRNA5Cholinergic receptor nicotinic alpha 5 subunit. (376 aa)
HOXD10Homeobox D10. (340 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (466 aa)
SLC1A2Amino acid transporter. (574 aa)
NCSTNNicastrin. (709 aa)
NTAN1Uncharacterized protein. (310 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (520 aa)
GLRA1Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
CSTBCystatin domain-containing protein; Belongs to the cystatin family. (98 aa)
ENSRBIP00000016831Uncharacterized protein. (141 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1943 aa)
NRXN3Neurexin 3. (882 aa)
KLHL5Kelch like family member 5. (709 aa)
ABHD12Abhydrolase domain containing 12. (393 aa)
SHANK1SH3 and multiple ankyrin repeat domains 1. (2054 aa)
SEZ6Seizure related 6 homolog. (968 aa)
TMOD1Tropomodulin 1. (359 aa)
CNP2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family. (421 aa)
EPHA4EPH receptor A4. (978 aa)
NTSR1Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (418 aa)
BBS1BBS1 domain-containing protein. (540 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (242 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
CNTN2Contactin 2. (1040 aa)
SLC1A1Amino acid transporter. (524 aa)
HOXD9Homeobox D9. (356 aa)
LOC108521200LAM_G_DOMAIN domain-containing protein. (470 aa)
PPT1Palmitoyl-protein thioesterase 1. (311 aa)
TSC1TSC complex subunit 1. (1164 aa)
ALKTyrosine-protein kinase receptor. (1316 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
PARK7Parkinsonism associated deglycase. (191 aa)
LOC108515161Uncharacterized protein. (536 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
CNTNAP2Uncharacterized protein. (681 aa)
UNC79Unc-79 homolog, NALCN channel complex subunit. (2637 aa)
HEXABeta-hexosaminidase. (529 aa)
FXNFrataxin. (210 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (204 aa)
BBS4Bardet-Biedl syndrome 4. (347 aa)
ENSRBIP00000028360Uncharacterized protein. (204 aa)
LOC108530786LAM_G_DOMAIN domain-containing protein. (554 aa)
OTOGOtogelin. (2827 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
HOMER2Homer scaffold protein 2. (384 aa)
ENSRBIP00000030690Uncharacterized protein. (126 aa)
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (518 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1432 aa)
ZIC1Zic family member 1. (447 aa)
NLGN2Neuroligin 2. (698 aa)
CRHBPCorticotropin releasing hormone binding protein. (275 aa)
ENSRBIP00000031784Uncharacterized protein. (291 aa)
OPRM1Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1266 aa)
DBHDopamine beta-hydroxylase. (620 aa)
GIPGastric inhibitory polypeptide. (151 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (717 aa)
OXR1Oxidation resistance 1. (846 aa)
SHANK2SH3 and multiple ankyrin repeat domains 2. (1850 aa)
HIPK2Homeodomain interacting protein kinase 2. (1209 aa)
EPS8Epidermal growth factor receptor pathway substrate 8. (837 aa)
SPTBN2Spectrin beta chain; Belongs to the spectrin family. (2389 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
CHRNA4Cholinergic receptor nicotinic alpha 4 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (575 aa)
ZFHX2Zinc finger homeobox 2. (2559 aa)
BTBD9BTB domain containing 9. (548 aa)
PTENUncharacterized protein. (555 aa)
GLRBGlycine receptor beta; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (481 aa)
CRHR1Corticotropin releasing hormone receptor 1; Belongs to the G-protein coupled receptor 2 family. (444 aa)
SEPTIN5Septin 5; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (441 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1079 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
PUM1Pumilio RNA binding family member 1. (1223 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (506 aa)
APPAmyloid beta precursor protein. (770 aa)
SNCGGamma-synuclein; Belongs to the synuclein family. (134 aa)
AGTPBP1ATP/GTP binding protein 1. (1258 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
PMP22Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family. (160 aa)
CCND2Uncharacterized protein; Belongs to the cyclin family. (244 aa)
HOXB8Homeobox B8. (243 aa)
CHRNA3Cholinergic receptor nicotinic alpha 3 subunit. (503 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2986 aa)
SLC7A11Solute carrier family 7 member 11. (501 aa)
SDK1Sidekick cell adhesion molecule 1. (2140 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
PCDH17Protocadherin 17. (1159 aa)
SPTBN4Spectrin beta chain; Belongs to the spectrin family. (2534 aa)
DMBX1Diencephalon/mesencephalon homeobox 1. (377 aa)
PCDH15Protocadherin related 15. (1915 aa)
SEZ6L2Seizure related 6 homolog like 2. (472 aa)
LGI4Leucine rich repeat LGI family member 4. (543 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
CLN8CLN8 transmembrane ER and ERGIC protein. (286 aa)
NRXN2Neurexin 2. (1661 aa)
KALRNKalirin RhoGEF kinase. (2940 aa)
AGRPAgouti related neuropeptide. (132 aa)
CARTPTCART prepropeptide. (116 aa)
SLITRK6SLIT and NTRK like family member 6. (841 aa)
CHL1Cell adhesion molecule L1 like. (1225 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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