(84 nodes) Regulation of cellular pH network (Rhinopithecus bieti)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GRN	Granulin precursor. (593 aa)
	SLC26A6	Solute carrier family 26 member 6. (759 aa)
	CA7	Carbonic anhydrase 7; Belongs to the alpha-carbonic anhydrase family. (264 aa)
	SLC4A3	Anion exchange protein. (1233 aa)
	TMEM106B	Transmembrane protein 106B. (274 aa)
	ATP6V1B2	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (540 aa)
	TMEM199	Transmembrane protein 199. (209 aa)
	ATP6V1F	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (147 aa)
	LACC1	Uncharacterized protein. (430 aa)
	AVP	Arginine vasopressin; Belongs to the vasopressin/oxytocin family. (164 aa)
	SLC9B1	Solute carrier family 9 member B1. (615 aa)
	SLAMF8	SLAM family member 8. (285 aa)
	ATP6V0A2	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
	SLC12A5	Solute carrier family 12 member 5. (1138 aa)
	SLC4A10	Anion exchange protein. (1144 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (877 aa)
	SLC9A2	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (812 aa)
	ENSRBIP00000032066	WD_REPEATS_REGION domain-containing protein. (360 aa)
	ENSRBIP00000031796	HECT domain-containing protein. (669 aa)
	NOX1	NADPH oxidase 1. (532 aa)
	CLIC4	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
	SLC9A4	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (797 aa)
	CA2	Carbonic anhydrase 2; Belongs to the alpha-carbonic anhydrase family. (284 aa)
	CFTR	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa)
	SNAPIN	SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
	RAB20	RAB20, member RAS oncogene family. (234 aa)
	TMEM175	Transmembrane protein 175. (504 aa)
	ENSRBIP00000026864	GPHR_N domain-containing protein. (157 aa)
	SLC9A6	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (540 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
	DMXL1	Dmx like 1. (2961 aa)
	ATP6AP1	ATPase H+ transporting accessory protein 1. (470 aa)
	TCIRG1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
	ATP6V0C	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
	ATP6V0A4	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (836 aa)
	MAFG	MAF bZIP transcription factor G. (162 aa)
	ATP1A4	Sodium/potassium-transporting ATPase subunit alpha. (1029 aa)
	TMEM9	Transmembrane protein 9. (183 aa)
	ENSRBIP00000004343	EF-hand domain-containing protein. (165 aa)
	AQP11	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (307 aa)
	SLC9C2	Solute carrier family 9 member C2 (putative). (1115 aa)
	SLC9C1	Solute carrier family 9 member C1. (1172 aa)
	CLN6	CLN6 transmembrane ER protein. (336 aa)
	SLC11A1	Solute carrier family 11 member 1. (497 aa)
	SLC26A3	Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (772 aa)
	ATP6V1H	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
	ATP6V0B	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (253 aa)
	PPT1	Palmitoyl-protein thioesterase 1. (311 aa)
	TMEM165	GDT1 family protein. (324 aa)
	ENSRBIP00000023020	Na_H_Exchanger domain-containing protein. (640 aa)
	RAB7A	RAB7A, member RAS oncogene family. (207 aa)
	CLN3	Battenin. (438 aa)
	SLC9A3	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (836 aa)
	LOC108531593	Uncharacterized protein. (446 aa)
	AVPR1B	Vasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (424 aa)
	TM9SF4	Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (644 aa)
	ATP6AP2	ATPase H+ transporting accessory protein 2. (290 aa)
	SLC4A1	Anion exchange protein. (959 aa)
	AVPR1A	Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (421 aa)
	SLC9A7	Solute carrier family 9 member A7. (591 aa)
	SLC4A4	Anion exchange protein. (1110 aa)
	SLC4A5	Anion exchange protein. (1088 aa)
	ENSRBIP00000015707	Uncharacterized protein. (239 aa)
	HVCN1	Hydrogen voltage gated channel 1. (273 aa)
	LOC108539701	Uncharacterized protein. (833 aa)
	VPS33A	VPS33A core subunit of CORVET and HOPS complexes; Belongs to the STXBP/unc-18/SEC1 family. (596 aa)
	CCDC115	Coiled-coil domain containing 115. (99 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
	RAB39A	RAB39A, member RAS oncogene family. (177 aa)
	RNASEK	Ribonuclease K. (133 aa)
	CXorf21	Chromosome X open reading frame 21. (301 aa)
	SLC4A8	Anion exchange protein. (1082 aa)
	SLC9A5	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (896 aa)
	ENSRBIP00000000376	Uncharacterized protein. (129 aa)
	SLC4A7	Anion exchange protein. (1259 aa)
	ATP6AP1L	ATPase H+ transporting accessory protein 1 like. (324 aa)
	CHP1	Uncharacterized protein. (163 aa)
	LRRK2	Protein kinase domain-containing protein. (537 aa)
	ATP5F1B	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (529 aa)
	SLC9A9	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (645 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	SLC9A1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
	RAB38	RAB38, member RAS oncogene family. (211 aa)
	SLC4A9	Anion exchange protein. (985 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP1A4	MAPK1	ENSRBIP00000010187	ENSRBIP00000026426	Sodium/potassium-transporting ATPase subunit alpha.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.909
ATP1A4	MAPK3	ENSRBIP00000010187	ENSRBIP00000000532	Sodium/potassium-transporting ATPase subunit alpha.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.909
ATP1A4	SLC9A1	ENSRBIP00000010187	ENSRBIP00000004877	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.673
ATP1A4	SLC9A2	ENSRBIP00000010187	ENSRBIP00000033042	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.490
ATP1A4	SLC9A3	ENSRBIP00000010187	ENSRBIP00000020194	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.423
ATP1A4	SLC9A4	ENSRBIP00000010187	ENSRBIP00000030168	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.510
ATP1A4	SLC9A5	ENSRBIP00000010187	ENSRBIP00000010247	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.599
ATP1A4	SLC9A7	ENSRBIP00000010187	ENSRBIP00000016821	Sodium/potassium-transporting ATPase subunit alpha.	Solute carrier family 9 member A7.	0.471
ATP1A4	SLC9A9	ENSRBIP00000010187	ENSRBIP00000012175	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.451
ATP5F1B	ATP6V0B	ENSRBIP00000012778	ENSRBIP00000006812	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family.	0.641
ATP5F1B	ATP6V0C	ENSRBIP00000012778	ENSRBIP00000025135	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.877
ATP5F1B	ATP6V1B2	ENSRBIP00000012778	ENSRBIP00000039280	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.701
ATP5F1B	ATP6V1F	ENSRBIP00000012778	ENSRBIP00000038207	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.784
ATP5F1B	ATP6V1H	ENSRBIP00000012778	ENSRBIP00000007200	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.	0.500
ATP6AP1	ATP6AP2	ENSRBIP00000025642	ENSRBIP00000018542	ATPase H+ transporting accessory protein 1.	ATPase H+ transporting accessory protein 2.	0.996
ATP6AP1	ATP6V0A2	ENSRBIP00000025642	ENSRBIP00000034544	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.990
ATP6AP1	ATP6V0A4	ENSRBIP00000025642	ENSRBIP00000023804	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.992
ATP6AP1	ATP6V0B	ENSRBIP00000025642	ENSRBIP00000006812	ATPase H+ transporting accessory protein 1.	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family.	0.998
ATP6AP1	ATP6V0C	ENSRBIP00000025642	ENSRBIP00000025135	ATPase H+ transporting accessory protein 1.	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.999
ATP6AP1	ATP6V1B2	ENSRBIP00000025642	ENSRBIP00000039280	ATPase H+ transporting accessory protein 1.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.989