85 items (Rhinopithecus bieti) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	SPPL3	Signal peptide peptidase like 3. (347 aa)
	STING1	Transmembrane protein 173. (379 aa)
	IDE	Insulin degrading enzyme; Belongs to the peptidase M16 family. (1019 aa)
	ARHGEF7	Rho guanine nucleotide exchange factor 7. (755 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (400 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	MFNG	Beta-1,3-N-acetylglucosaminyltransferase. (321 aa)
	TICAM1	Toll like receptor adaptor molecule 1. (515 aa)
	MMP9	Matrix metallopeptidase 9. (703 aa)
	AMFR	Autocrine motility factor receptor. (645 aa)
	FLOT1	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
	GCG	Glucagon. (180 aa)
	CTHRC1	Collagen triple helix repeat containing 1. (243 aa)
	ENSRBIP00000030563	Uncharacterized protein. (332 aa)
	ADD2	Adducin 2. (738 aa)
	TAF1	TATA-box binding protein associated factor 1. (1713 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	TRIB3	Tribbles pseudokinase 3. (385 aa)
	DTX3L	Deltex E3 ubiquitin ligase 3L. (744 aa)
	ZNF268	Zinc finger protein 268. (946 aa)
	HIPK2	Homeodomain interacting protein kinase 2. (1209 aa)
	EP300	E1A binding protein p300. (2296 aa)
	ANXA2	Annexin. (357 aa)
	ENSRBIP00000035705	Uncharacterized protein. (200 aa)
	DERL1	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa)
	APP	Amyloid beta precursor protein. (770 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	PLCL2	Phosphoinositide phospholipase C. (1035 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	HSF1	Heat shock transcription factor 1. (489 aa)
	MARK3	Non-specific serine/threonine protein kinase. (744 aa)
	BLK	Tyrosine-protein kinase. (505 aa)
	EPHB6	EPH receptor B6. (1018 aa)
	PPP2CA	Serine/threonine-protein phosphatase. (309 aa)
	BMP2	Bone morphogenetic protein 2. (321 aa)
	MAPRE3	Microtubule associated protein RP/EB family member 3. (266 aa)
	PLXND1	Plexin D1. (1884 aa)
	ENSRBIP00000004311	Uncharacterized protein. (856 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (432 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (443 aa)
	RAPGEF2	Rap guanine nucleotide exchange factor 2. (1474 aa)
	ADD1	Adducin 1. (754 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4129 aa)
	TCF7L2	HMG box domain-containing protein. (376 aa)
	HIP1R	Huntingtin interacting protein 1 related. (1068 aa)
	APOE	Apolipoprotein E. (317 aa)
	BAMBI	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
	TIAM1	T cell lymphoma invasion and metastasis 1. (1591 aa)
	CAPRIN2	Caprin family member 2. (1096 aa)
	NVL	Uncharacterized protein. (857 aa)
	HFE	Homeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
	KRIT1	Uncharacterized protein. (736 aa)
	PPP2CB	Serine/threonine-protein phosphatase. (304 aa)
	ENSRBIP00000016589	Uncharacterized protein. (267 aa)
	TERT	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1167 aa)
	LRP1	LDL receptor related protein 1. (4461 aa)
	CSF3	Colony stimulating factor 3. (204 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
	LOC108539701	Uncharacterized protein. (833 aa)
	POLDIP2	DNA polymerase delta interacting protein 2. (408 aa)
	MEN1	Menin 1. (610 aa)
	PLCL1	Phosphoinositide phospholipase C. (997 aa)
	LRRK2	Protein kinase domain-containing protein. (537 aa)
	SPTA1	Spectrin alpha, erythrocytic 1. (2490 aa)
	ENSRBIP00000012047	Peptidyl-prolyl cis-trans isomerase. (154 aa)
	DACT1	Dishevelled binding antagonist of beta catenin 1. (837 aa)
	CLDN5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
	EPB41L5	Erythrocyte membrane protein band 4.1 like 5. (716 aa)
	EPB41	Erythrocyte membrane protein band 4.1. (865 aa)
	RFNG	RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (317 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
	BDNF	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (312 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	PRKN	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
	LFNG	Beta-1,3-N-acetylglucosaminyltransferase. (349 aa)
	SPON1	Spondin 1. (924 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (163 aa)
	ENSRBIP00000006659	Protein kinase domain-containing protein. (275 aa)
	SPAG8	Sperm associated antigen 8. (475 aa)
	TRIM21	Tripartite motif containing 21. (475 aa)
	ACE	Angiotensin-converting enzyme. (1307 aa)
	AKTIP	AKT interacting protein. (168 aa)
	ENSRBIP00000022247	Uncharacterized protein. (70 aa)
	STK3	Serine/threonine kinase 3. (490 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	CDK5	ENSRBIP00000007933	ENSRBIP00000024465	Tyrosine-protein kinase.	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	0.410
ABL1	ENSRBIP00000006659	ENSRBIP00000007933	ENSRBIP00000006659	Tyrosine-protein kinase.	Protein kinase domain-containing protein.	0.410
ABL1	EPHB6	ENSRBIP00000007933	ENSRBIP00000042440	Tyrosine-protein kinase.	EPH receptor B6.	0.907
ACE	ADD1	ENSRBIP00000005789	ENSRBIP00000003494	Angiotensin-converting enzyme.	Adducin 1.	0.443
ACE	APOE	ENSRBIP00000005789	ENSRBIP00000021650	Angiotensin-converting enzyme.	Apolipoprotein E.	0.558
ADD1	ACE	ENSRBIP00000003494	ENSRBIP00000005789	Adducin 1.	Angiotensin-converting enzyme.	0.443
ADD1	ADD2	ENSRBIP00000003494	ENSRBIP00000031146	Adducin 1.	Adducin 2.	0.914
ADD1	EPB41	ENSRBIP00000003494	ENSRBIP00000009741	Adducin 1.	Erythrocyte membrane protein band 4.1.	0.695
ADD2	ADD1	ENSRBIP00000031146	ENSRBIP00000003494	Adducin 2.	Adducin 1.	0.914
ADD2	EPB41	ENSRBIP00000031146	ENSRBIP00000009741	Adducin 2.	Erythrocyte membrane protein band 4.1.	0.694
AMFR	DERL1	ENSRBIP00000026873	ENSRBIP00000037845	Autocrine motility factor receptor.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.985
AMFR	ENSRBIP00000004311	ENSRBIP00000026873	ENSRBIP00000004311	Autocrine motility factor receptor.	Uncharacterized protein.	0.419
AMFR	NVL	ENSRBIP00000026873	ENSRBIP00000017733	Autocrine motility factor receptor.	Uncharacterized protein.	0.419
ANXA2	APP	ENSRBIP00000035599	ENSRBIP00000038205	Annexin.	Amyloid beta precursor protein.	0.406
ANXA2	CAV1	ENSRBIP00000035599	ENSRBIP00000015374	Annexin.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.432
APOE	ACE	ENSRBIP00000021650	ENSRBIP00000005789	Apolipoprotein E.	Angiotensin-converting enzyme.	0.558
APOE	APP	ENSRBIP00000021650	ENSRBIP00000038205	Apolipoprotein E.	Amyloid beta precursor protein.	0.908
APOE	BDNF	ENSRBIP00000021650	ENSRBIP00000008117	Apolipoprotein E.	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	0.479
APOE	CAV1	ENSRBIP00000021650	ENSRBIP00000015374	Apolipoprotein E.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.406
APOE	LRP1	ENSRBIP00000021650	ENSRBIP00000016050	Apolipoprotein E.	LDL receptor related protein 1.	0.983