STRINGSTRING
LEP LEP CARTPT CARTPT NUCB2 NUCB2 PPARA PPARA GHSR GHSR SPX SPX MKKS MKKS BBS4 BBS4 BBS2 BBS2 NENF NENF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
CARTPTCART prepropeptide. (116 aa)
NUCB2Nucleobindin 2. (420 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
SPXSpexin hormone. (116 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
BBS4Bardet-Biedl syndrome 4. (347 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (717 aa)
NENFNeudesin neurotrophic factor; Belongs to the cytochrome b5 family. (170 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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