node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BBS2 | BBS4 | ENSRBIP00000032208 | ENSRBIP00000028239 | Bardet-Biedl syndrome 2 protein homolog. | Bardet-Biedl syndrome 4. | 0.997 |
BBS2 | MKKS | ENSRBIP00000032208 | ENSRBIP00000022464 | Bardet-Biedl syndrome 2 protein homolog. | McKusick-Kaufman syndrome. | 0.436 |
BBS4 | BBS2 | ENSRBIP00000028239 | ENSRBIP00000032208 | Bardet-Biedl syndrome 4. | Bardet-Biedl syndrome 2 protein homolog. | 0.997 |
CARTPT | LEP | ENSRBIP00000001289 | ENSRBIP00000041070 | CART prepropeptide. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.499 |
CYP27B1 | MED1 | ENSRBIP00000016600 | ENSRBIP00000014931 | Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.802 |
CYP27B1 | RXRA | ENSRBIP00000016600 | ENSRBIP00000038762 | Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. | Retinoid X receptor alpha. | 0.889 |
CYP27B1 | VDR | ENSRBIP00000016600 | ENSRBIP00000016468 | Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. | Vitamin D receptor. | 0.512 |
GHRL | GHSR | ENSRBIP00000029484 | ENSRBIP00000009607 | Ghrelin and obestatin prepropeptide. | Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. | 0.998 |
GHRL | LEP | ENSRBIP00000029484 | ENSRBIP00000041070 | Ghrelin and obestatin prepropeptide. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.892 |
GHSR | GHRL | ENSRBIP00000009607 | ENSRBIP00000029484 | Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. | Ghrelin and obestatin prepropeptide. | 0.998 |
GHSR | LEP | ENSRBIP00000009607 | ENSRBIP00000041070 | Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.430 |
LEP | CARTPT | ENSRBIP00000041070 | ENSRBIP00000001289 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | CART prepropeptide. | 0.499 |
LEP | GHRL | ENSRBIP00000041070 | ENSRBIP00000029484 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Ghrelin and obestatin prepropeptide. | 0.892 |
LEP | GHSR | ENSRBIP00000041070 | ENSRBIP00000009607 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. | 0.430 |
LEP | PPARA | ENSRBIP00000041070 | ENSRBIP00000007565 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Peroxisome proliferator activated receptor alpha. | 0.530 |
LEP | VDR | ENSRBIP00000041070 | ENSRBIP00000016468 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Vitamin D receptor. | 0.409 |
MED1 | CYP27B1 | ENSRBIP00000014931 | ENSRBIP00000016600 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.802 |
MED1 | PPARA | ENSRBIP00000014931 | ENSRBIP00000007565 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Peroxisome proliferator activated receptor alpha. | 0.857 |
MED1 | RXRA | ENSRBIP00000014931 | ENSRBIP00000038762 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Retinoid X receptor alpha. | 0.978 |
MED1 | VDR | ENSRBIP00000014931 | ENSRBIP00000016468 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Vitamin D receptor. | 0.896 |