STRINGSTRING
RARA RARA LOC108518721 LOC108518721 IL23R IL23R LOC108527168 LOC108527168 IL27RA IL27RA GATA3 GATA3 RASGRP1 RASGRP1 AXL AXL ENSRBIP00000015630 ENSRBIP00000015630 SLC7A5 SLC7A5 IL1B IL1B NR1H4 NR1H4 NLRP6 NLRP6 LTA LTA HLA-DPA1 HLA-DPA1 TXK TXK IL12RB1 IL12RB1 TNFSF4 TNFSF4 ENSRBIP00000019541 ENSRBIP00000019541 FOXP3 FOXP3 IL20RB IL20RB SLAMF1 SLAMF1 INHBA INHBA HRAS HRAS ZNF683 ZNF683 ENSRBIP00000022247 ENSRBIP00000022247 CD14 CD14 LOC108531166 LOC108531166 SIRPA SIRPA ISL1 ISL1 VSIR VSIR SLC11A1 SLC11A1 TLR3 TLR3 ABL1 ABL1 TYK2 TYK2 IL1R1 IL1R1 C1QBP C1QBP CEBPG CEBPG HAVCR2 HAVCR2 PGLYRP2 PGLYRP2 PRNP PRNP RIPK3 RIPK3 NOD2 NOD2 RIPK2 RIPK2 CD226 CD226 IL27 IL27 SCRIB SCRIB IL12RB2 IL12RB2 JAK2 JAK2 IL21 IL21 IL10 IL10 WNT5A WNT5A PDE4D PDE4D CLEC7A CLEC7A IL18R1 IL18R1 PDE4B PDE4B PDCD1LG2 PDCD1LG2 LOC108539010 LOC108539010 ENSRBIP00000039311 ENSRBIP00000039311 SLAMF6 SLAMF6 PYCARD PYCARD IL2 IL2 CD2 CD2 ZC3H12A ZC3H12A ZFPM1 ZFPM1 IL33 IL33 PGLYRP1 PGLYRP1 DDIT3 DDIT3 HLA-DPB1 HLA-DPB1 KLRK1 KLRK1 IL12A IL12A IRF8 IRF8 ENSRBIP00000032286 ENSRBIP00000032286 PGLYRP3 PGLYRP3 PTPN22 PTPN22 ARID5A ARID5A BCL3 BCL3 ISG15 ISG15 IL1RL1 IL1RL1 ENSRBIP00000028325 ENSRBIP00000028325 IL18 IL18 FADD FADD SASH3 SASH3 CRTAM CRTAM CCR7 CCR7 TLR8 TLR8 INHA INHA HMHB1 HMHB1 FAM49B FAM49B IL23A IL23A TLR7 TLR7 FZD5 FZD5 TRIM27 TRIM27 GAS6 GAS6 CD96 CD96 TLR4 TLR4 LRRC1 LRRC1 CD3E CD3E CD244 CD244 CD276 CD276 BTN3A1 BTN3A1 CD160 CD160
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RARARetinoic acid receptor alpha. (478 aa)
LOC108518721Ig-like domain-containing protein. (407 aa)
IL23RInterleukin 23 receptor. (629 aa)
LOC108527168Uncharacterized protein. (200 aa)
IL27RAInterleukin 27 receptor subunit alpha. (724 aa)
GATA3GATA binding protein 3. (444 aa)
RASGRP1RAS guanyl releasing protein 1. (841 aa)
AXLAXL receptor tyrosine kinase. (892 aa)
ENSRBIP00000015630Uncharacterized protein. (49 aa)
SLC7A5Solute carrier family 7 member 5. (507 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (481 aa)
NLRP6NLR family pyrin domain containing 6. (1041 aa)
LTALymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
TXKTyrosine-protein kinase. (498 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (652 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
ENSRBIP00000019541Ig-like domain-containing protein. (264 aa)
FOXP3Forkhead box P3. (456 aa)
IL20RBInterleukin 20 receptor subunit beta. (311 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (357 aa)
INHBAInhibin subunit beta A. (426 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ZNF683Zinc finger protein 683. (541 aa)
ENSRBIP00000022247Uncharacterized protein. (70 aa)
CD14CD14 molecule. (384 aa)
LOC108531166AIG1-type G domain-containing protein. (307 aa)
SIRPAUncharacterized protein. (505 aa)
ISL1ISL LIM homeobox 1. (349 aa)
VSIRV-set immunoregulatory receptor. (359 aa)
SLC11A1Solute carrier family 11 member 1. (497 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (903 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
TYK2Tyrosine-protein kinase. (1187 aa)
IL1R1Interleukin 1 receptor type 1. (568 aa)
C1QBPComplement C1q binding protein. (281 aa)
CEBPGCCAAT enhancer binding protein gamma. (150 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (294 aa)
PGLYRP2Peptidoglycan recognition protein 2. (620 aa)
PRNPPrion protein; Belongs to the prion family. (223 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1153 aa)
RIPK2Receptor interacting serine/threonine kinase 2. (443 aa)
CD226CD226 molecule. (356 aa)
IL27Interleukin 27. (244 aa)
SCRIBScribble planar cell polarity protein. (1660 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (817 aa)
JAK2Tyrosine-protein kinase. (1083 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
IL10Interleukin 10. (178 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PDE4DPhosphodiesterase. (809 aa)
CLEC7AC-type lectin domain containing 7A. (257 aa)
IL18R1Interleukin 18 receptor 1. (525 aa)
PDE4BPhosphodiesterase. (736 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (248 aa)
LOC108539010Galectin. (136 aa)
ENSRBIP00000039311Galectin. (126 aa)
SLAMF6SLAM family member 6. (332 aa)
PYCARDPYD and CARD domain containing. (195 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
CD2CD2 molecule. (351 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (570 aa)
ZFPM1Uncharacterized protein. (143 aa)
IL33Interleukin 33. (269 aa)
PGLYRP1Peptidoglycan-recognition protein; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity. (196 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
KLRK1Killer cell lectin like receptor K1. (204 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
IRF8Interferon regulatory factor 8. (426 aa)
ENSRBIP00000032286Uncharacterized protein. (185 aa)
PGLYRP3Peptidoglycan recognition protein 3. (341 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (779 aa)
ARID5AAT-rich interaction domain 5A. (702 aa)
BCL3BCL3 transcription coactivator. (405 aa)
ISG15ISG15 ubiquitin like modifier. (167 aa)
IL1RL1Interleukin 1 receptor like 1. (556 aa)
ENSRBIP00000028325Galectin. (129 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
SASH3SAM and SH3 domain containing 3. (357 aa)
CRTAMCytotoxic and regulatory T cell molecule. (344 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (375 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1016 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (367 aa)
HMHB1Histocompatibility minor HB-1. (40 aa)
FAM49BFamily with sequence similarity 49 member B. (324 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
TRIM27Tripartite motif containing 27. (513 aa)
GAS6Growth arrest specific 6. (623 aa)
CD96CD96 molecule. (587 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
CD3ECD3e molecule. (198 aa)
CD244CD244 molecule. (367 aa)
CD276Uncharacterized protein. (299 aa)
BTN3A1Butyrophilin subfamily 3 member A1. (524 aa)
CD160CD160 molecule. (232 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.