STRINGSTRING
STAT3 STAT3 EREG EREG CSK CSK TLR3 TLR3 IL1RL2 IL1RL2 ENSRBIP00000007353 ENSRBIP00000007353 ISL1 ISL1 TSLP TSLP ENSRBIP00000006958 ENSRBIP00000006958 IRAK3 IRAK3 TLR4 TLR4 AKIRIN2 AKIRIN2 GAS6 GAS6 TMEM106A TMEM106A LOC108539668 LOC108539668 TLR7 TLR7 SCIMP SCIMP RIPK2 RIPK2 LOC108539768 LOC108539768 NOD2 NOD2 IL17D IL17D ENSRBIP00000002079 ENSRBIP00000002079 MAPKAPK2 MAPKAPK2 SYT11 SYT11 ADORA2B ADORA2B LOC108525313 LOC108525313 INAVA INAVA DHX9 DHX9 AFAP1L2 AFAP1L2 IL33 IL33 TRAF6 TRAF6 IL1RAP IL1RAP TRPV4 TRPV4 LOC108524385 LOC108524385 NLRC3 NLRC3 CD84 CD84 BPI BPI ZC3H12A ZC3H12A LBP LBP CD74 CD74 POU2AF1 POU2AF1 APP APP IL36A IL36A PYCARD PYCARD PTPN6 PTPN6 IL16 IL16 ENSRBIP00000039905 ENSRBIP00000039905 RAB7B RAB7B HGF HGF FOXJ1 FOXJ1 CLEC7A CLEC7A LEP LEP WNT5A WNT5A IL10 IL10 NOS2 NOS2 IL6 IL6 BCL10 BCL10 IL17A IL17A BTK BTK C1QTNF4 C1QTNF4 LOC108516810 LOC108516810 DDX58 DDX58 MAPK13 MAPK13 ENSRBIP00000032719 ENSRBIP00000032719 NOD1 NOD1 IFNG IFNG PTPN22 PTPN22 ARID5A ARID5A IL17RC IL17RC GHRL GHRL TLR9 TLR9 TMEM130 TMEM130 CD200R1 CD200R1 KLF2 KLF2 SPON2 SPON2 ZBTB20 ZBTB20 TREM2 TREM2 PTPN11 PTPN11 NLRX1 NLRX1 MBP MBP ENSRBIP00000026419 ENSRBIP00000026419 RABGEF1 RABGEF1 F2R F2R NMB NMB IL17F IL17F SPHK2 SPHK2 MMP8 MMP8 TICAM1 TICAM1 LPL LPL TLR8 TLR8 AIF1 AIF1 ARHGEF2 ARHGEF2 SIRPA SIRPA SYK SYK AGER AGER NLRP12 NLRP12 ENSRBIP00000022247 ENSRBIP00000022247 TLR1 TLR1 CX3CL1 CX3CL1 LILRA5 LILRA5 XBP1 XBP1 IL37 IL37 SLAMF1 SLAMF1 TNFAIP3 TNFAIP3 INPP5D INPP5D HYAL2 HYAL2 FOXP3 FOXP3 MAVS MAVS TNFSF4 TNFSF4 C1QTNF3 C1QTNF3 POU2F2 POU2F2 TIRAP TIRAP NR1H4 NR1H4 IL1B IL1B NCKAP1L NCKAP1L ENSRBIP00000016878 ENSRBIP00000016878 ENSRBIP00000015630 ENSRBIP00000015630 NLRP10 NLRP10 BANK1 BANK1 ORM1 ORM1 IL27RA IL27RA SELENOS SELENOS IL17RA IL17RA PLCG2 PLCG2 BSG BSG NMBR NMBR LOC108518721 LOC108518721 SOCS5 SOCS5 ENSRBIP00000011851 ENSRBIP00000011851 CYBA CYBA HAVCR2 HAVCR2 IFIH1 IFIH1 SETD4 SETD4 MYD88 MYD88 CARD9 CARD9 CD36 CD36 ENSRBIP00000009767 ENSRBIP00000009767 GHSR GHSR AQP4 AQP4 IL6R IL6R
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STAT3Signal transducer and activator of transcription. (770 aa)
EREGEpiregulin. (169 aa)
CSKTyrosine-protein kinase. (450 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (903 aa)
IL1RL2Interleukin 1 receptor like 2. (652 aa)
ENSRBIP00000007353A20-type domain-containing protein. (128 aa)
ISL1ISL LIM homeobox 1. (349 aa)
TSLPThymic stromal lymphopoietin. (159 aa)
ENSRBIP00000006958TNF receptor-associated factor. (473 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (596 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
AKIRIN2Akirin 2. (203 aa)
GAS6Growth arrest specific 6. (623 aa)
TMEM106ATransmembrane protein 106A. (262 aa)
LOC108539668ASCH domain-containing protein. (158 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
SCIMPSLP adaptor and CSK interacting membrane protein. (143 aa)
RIPK2Receptor interacting serine/threonine kinase 2. (443 aa)
LOC108539768ASCH domain-containing protein. (157 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1153 aa)
IL17DInterleukin 17D. (189 aa)
ENSRBIP00000002079Uncharacterized protein. (202 aa)
MAPKAPK2MAPK activated protein kinase 2. (392 aa)
SYT11Synaptotagmin 11. (431 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (394 aa)
LOC108525313ASCH domain-containing protein. (255 aa)
INAVAInnate immunity activator. (703 aa)
DHX9DExH-box helicase 9. (1275 aa)
AFAP1L2Actin filament associated protein 1 like 2. (820 aa)
IL33Interleukin 33. (269 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
IL1RAPInterleukin 1 receptor accessory protein. (680 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
LOC108524385Uncharacterized protein. (348 aa)
NLRC3NLR family CARD domain containing 3. (1091 aa)
CD84CD84 molecule. (328 aa)
BPIBactericidal permeability increasing protein. (487 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (570 aa)
LBPLipopolysaccharide binding protein. (481 aa)
CD74CD74 molecule. (294 aa)
POU2AF1POU class 2 homeobox associating factor 1. (257 aa)
APPAmyloid beta precursor protein. (770 aa)
IL36AInterleukin-1. (158 aa)
PYCARDPYD and CARD domain containing. (195 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (602 aa)
IL16Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1376 aa)
ENSRBIP00000039905VPS9 domain-containing protein. (259 aa)
RAB7BRAB7B, member RAS oncogene family. (199 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
FOXJ1Forkhead box J1. (421 aa)
CLEC7AC-type lectin domain containing 7A. (257 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
IL10Interleukin 10. (178 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1126 aa)
IL6Interleukin 6. (214 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
IL17AInterleukin 17A. (155 aa)
BTKTyrosine-protein kinase. (673 aa)
C1QTNF4C1q and TNF related 4. (316 aa)
LOC108516810Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (330 aa)
DDX58DExD/H-box helicase 58. (914 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
ENSRBIP00000032719SH2 domain-containing protein. (203 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (159 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (779 aa)
ARID5AAT-rich interaction domain 5A. (702 aa)
IL17RCInterleukin 17 receptor C. (787 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
TLR9TIR domain-containing protein. (1033 aa)
TMEM130Transmembrane protein 130. (424 aa)
CD200R1CD200 receptor 1. (348 aa)
KLF2Uncharacterized protein. (194 aa)
SPON2Spondin 2. (331 aa)
ZBTB20Zinc finger and BTB domain containing 20. (741 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (231 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
NLRX1NLR family member X1. (972 aa)
MBPMyelin basic protein. (330 aa)
ENSRBIP00000026419Uncharacterized protein. (249 aa)
RABGEF1Uncharacterized protein. (430 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
NMBUncharacterized protein. (203 aa)
IL17FInterleukin 17F. (163 aa)
SPHK2Sphingosine kinase 2. (658 aa)
MMP8Matrix metallopeptidase 8. (465 aa)
TICAM1Toll like receptor adaptor molecule 1. (515 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (529 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1016 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1003 aa)
SIRPAUncharacterized protein. (505 aa)
SYKUncharacterized protein. (331 aa)
AGERUncharacterized protein. (417 aa)
NLRP12NLR family pyrin domain containing 12. (1055 aa)
ENSRBIP00000022247Uncharacterized protein. (70 aa)
TLR1Toll like receptor 1. (703 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (407 aa)
LILRA5Uncharacterized protein. (299 aa)
XBP1BZIP domain-containing protein. (380 aa)
IL37Interleukin-1. (223 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (357 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1194 aa)
HYAL2Hyaluronidase. (467 aa)
FOXP3Forkhead box P3. (456 aa)
MAVSMitochondrial antiviral signaling protein. (539 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
C1QTNF3C1q domain-containing protein. (263 aa)
POU2F2POU domain protein. (614 aa)
TIRAPTIR domain containing adaptor protein. (233 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (481 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
ENSRBIP00000016878Uncharacterized protein. (251 aa)
ENSRBIP00000015630Uncharacterized protein. (49 aa)
NLRP10NLR family pyrin domain containing 10. (626 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (762 aa)
ORM1Orosomucoid 1. (180 aa)
IL27RAInterleukin 27 receptor subunit alpha. (724 aa)
SELENOSSelenoprotein S. (210 aa)
IL17RAInterleukin 17 receptor A. (865 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
BSGBasigin (Ok blood group). (385 aa)
NMBRNeuromedin B receptor; Belongs to the G-protein coupled receptor 1 family. (389 aa)
LOC108518721Ig-like domain-containing protein. (407 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
ENSRBIP00000011851Uncharacterized protein. (107 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (294 aa)
IFIH1Interferon induced with helicase C domain 1. (1014 aa)
SETD4SET domain containing 4. (440 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
CARD9Caspase recruitment domain family member 9. (536 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
ENSRBIP00000009767Uncharacterized protein. (546 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
AQP4Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)
IL6RInterleukin 6 receptor. (499 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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