STRINGSTRING
GHRL GHRL CLEC7A CLEC7A LEP LEP WNT5A WNT5A IL10 IL10 THBS1 THBS1 RIPK1 RIPK1 IL6 IL6 JAK2 JAK2 IL17A IL17A TNFRSF8 TNFRSF8 BTK BTK ENSRBIP00000043094 ENSRBIP00000043094 CD34 CD34 EPHB2 EPHB2 TSPO TSPO ACP5 ACP5 OAS1 OAS1 LY96 LY96 CACTIN CACTIN PIK3R1 PIK3R1 ENSRBIP00000002079 ENSRBIP00000002079 FOXP1 FOXP1 POMC POMC NOD2 NOD2 AKAP12 AKAP12 RIPK2 RIPK2 PSEN1 PSEN1 ENSRBIP00000004373 ENSRBIP00000004373 DICER1 DICER1 FZD5 FZD5 TMEM106A TMEM106A TRIM27 TRIM27 GAS6 GAS6 DDT DDT GPNMB GPNMB TLR4 TLR4 IRAK3 IRAK3 ERRFI1 ERRFI1 ISL1 ISL1 VSIR VSIR OAS3 OAS3 LTF LTF TLR3 TLR3 STAT3 STAT3 ABCC8 ABCC8 NFATC4 NFATC4 IGF1 IGF1 GHSR GHSR ENSRBIP00000009767 ENSRBIP00000009767 CD36 CD36 CARD9 CARD9 MYD88 MYD88 SETD4 SETD4 IFIH1 IFIH1 HAVCR2 HAVCR2 CYBA CYBA ADIPOQ ADIPOQ RARA RARA HSPB1 HSPB1 AKAP8 AKAP8 CD33 CD33 LOC108518721 LOC108518721 CLU CLU GPR18 GPR18 LRRK2 LRRK2 PLCG2 PLCG2 SELENOS SELENOS ENSRBIP00000013453 ENSRBIP00000013453 ENSRBIP00000013454 ENSRBIP00000013454 IL27RA IL27RA ORM1 ORM1 RASGRP1 RASGRP1 AXL AXL LOC108539701 LOC108539701 ARFGEF2 ARFGEF2 CLEC4A CLEC4A ENSRBIP00000016878 ENSRBIP00000016878 NR1H4 NR1H4 TIRAP TIRAP MAVS MAVS FOXP3 FOXP3 TNFAIP3 TNFAIP3 SLAMF1 SLAMF1 IL37 IL37 LILRA5 LILRA5 CX3CL1 CX3CL1 ENSRBIP00000022247 ENSRBIP00000022247 CD14 CD14 CHRNA7 CHRNA7 PF4 PF4 AZU1 AZU1 IFNGR1 IFNGR1 AGER AGER SYK SYK SIRPA SIRPA ARHGEF2 ARHGEF2 IL23A IL23A TUBB3 TUBB3 HDAC2 HDAC2 LPL LPL TICAM1 TICAM1 HLA-E HLA-E MMP8 MMP8 SPHK2 SPHK2 OAS2 OAS2 CYBB CYBB SASH3 SASH3 FADD FADD ENSRBIP00000026419 ENSRBIP00000026419 CIDEA CIDEA IL18 IL18 PTPN11 PTPN11 TREM2 TREM2 ZBTB20 ZBTB20 LOC108521226 LOC108521226 SPON2 SPON2 PTPRJ PTPRJ ZFP36 ZFP36 CCL19 CCL19 FRMD8 FRMD8 BCL3 BCL3 NFKBIL1 NFKBIL1 ARID5A ARID5A PTPN22 PTPN22 MIF MIF NOD1 NOD1 ENSRBIP00000032719 ENSRBIP00000032719 DDX58 DDX58 LOC108516810 LOC108516810 C1QTNF4 C1QTNF4 MC1R MC1R MAPKAPK2 MAPKAPK2 SYT11 SYT11 UBE2J1 UBE2J1 DHX9 DHX9 GSTP1 GSTP1 ILRUN ILRUN IL33 IL33 LOC108524385 LOC108524385 NLRC3 NLRC3 BPI BPI CD84 CD84 ZC3H12A ZC3H12A DEFB114 DEFB114 ARG2 ARG2 ANGPT1 ANGPT1 LBP LBP APP APP CD2 CD2 PYCARD PYCARD CX3CR1 CX3CR1 PTPN6 PTPN6 PTPRC PTPRC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GHRLGhrelin and obestatin prepropeptide. (117 aa)
CLEC7AC-type lectin domain containing 7A. (257 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
IL10Interleukin 10. (178 aa)
THBS1Thrombospondin 1. (1170 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (672 aa)
IL6Interleukin 6. (214 aa)
JAK2Tyrosine-protein kinase. (1083 aa)
IL17AInterleukin 17A. (155 aa)
TNFRSF8TNF receptor superfamily member 8. (576 aa)
BTKTyrosine-protein kinase. (673 aa)
ENSRBIP00000043094Uncharacterized protein. (97 aa)
CD34CD34 molecule. (385 aa)
EPHB2EPH receptor B2. (1082 aa)
TSPOTranslocator protein. (169 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
OAS12'-5'-oligoadenylate synthetase 1. (408 aa)
LY96Lymphocyte antigen 96. (160 aa)
CACTINCactin, spliceosome C complex subunit. (804 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ENSRBIP00000002079Uncharacterized protein. (202 aa)
FOXP1Forkhead box P1. (693 aa)
POMCProopiomelanocortin. (251 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1153 aa)
AKAP12A-kinase anchoring protein 12. (1783 aa)
RIPK2Receptor interacting serine/threonine kinase 2. (443 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (432 aa)
ENSRBIP00000004373Ig-like domain-containing protein; Belongs to the MHC class I family. (391 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1920 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
TMEM106ATransmembrane protein 106A. (262 aa)
TRIM27Tripartite motif containing 27. (513 aa)
GAS6Growth arrest specific 6. (623 aa)
DDTUncharacterized protein. (143 aa)
GPNMBGlycoprotein nmb. (561 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (596 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (462 aa)
ISL1ISL LIM homeobox 1. (349 aa)
VSIRV-set immunoregulatory receptor. (359 aa)
OAS32'-5'-oligoadenylate synthetase 3. (1092 aa)
LTFLactotransferrin; Belongs to the transferrin family. (710 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (903 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
ABCC8ATP binding cassette subfamily C member 8. (1585 aa)
NFATC4Nuclear factor of activated T cells 4. (909 aa)
IGF1Insulin like growth factor 1. (208 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
ENSRBIP00000009767Uncharacterized protein. (546 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
CARD9Caspase recruitment domain family member 9. (536 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
SETD4SET domain containing 4. (440 aa)
IFIH1Interferon induced with helicase C domain 1. (1014 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (294 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (275 aa)
RARARetinoic acid receptor alpha. (478 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
AKAP8A-kinase anchoring protein 8; Belongs to the AKAP95 family. (646 aa)
CD33CD33 molecule. (499 aa)
LOC108518721Ig-like domain-containing protein. (407 aa)
CLUClusterin; Belongs to the clusterin family. (515 aa)
GPR18G protein-coupled receptor 18; Belongs to the G-protein coupled receptor 1 family. (331 aa)
LRRK2Protein kinase domain-containing protein. (537 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
SELENOSSelenoprotein S. (210 aa)
ENSRBIP00000013453SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (173 aa)
ENSRBIP00000013454Uncharacterized protein. (163 aa)
IL27RAInterleukin 27 receptor subunit alpha. (724 aa)
ORM1Orosomucoid 1. (180 aa)
RASGRP1RAS guanyl releasing protein 1. (841 aa)
AXLAXL receptor tyrosine kinase. (892 aa)
LOC108539701Uncharacterized protein. (833 aa)
ARFGEF2ADP ribosylation factor guanine nucleotide exchange factor 2. (1785 aa)
CLEC4AC-type lectin domain family 4 member A. (239 aa)
ENSRBIP00000016878Uncharacterized protein. (251 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (481 aa)
TIRAPTIR domain containing adaptor protein. (233 aa)
MAVSMitochondrial antiviral signaling protein. (539 aa)
FOXP3Forkhead box P3. (456 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (357 aa)
IL37Interleukin-1. (223 aa)
LILRA5Uncharacterized protein. (299 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (407 aa)
ENSRBIP00000022247Uncharacterized protein. (70 aa)
CD14CD14 molecule. (384 aa)
CHRNA7Uncharacterized protein. (503 aa)
PF4C-X-C motif chemokine. (101 aa)
AZU1Azurocidin 1. (250 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
AGERUncharacterized protein. (417 aa)
SYKUncharacterized protein. (331 aa)
SIRPAUncharacterized protein. (505 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1003 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
TUBB3G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the tubulin family. (773 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (529 aa)
TICAM1Toll like receptor adaptor molecule 1. (515 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (359 aa)
MMP8Matrix metallopeptidase 8. (465 aa)
SPHK2Sphingosine kinase 2. (658 aa)
OAS22'-5'-oligoadenylate synthetase 2. (687 aa)
CYBBCytochrome b-245 beta chain. (513 aa)
SASH3SAM and SH3 domain containing 3. (357 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
ENSRBIP00000026419Uncharacterized protein. (249 aa)
CIDEACell death inducing DFFA like effector a. (219 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (231 aa)
ZBTB20Zinc finger and BTB domain containing 20. (741 aa)
LOC108521226Uncharacterized protein. (418 aa)
SPON2Spondin 2. (331 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1336 aa)
ZFP36ZFP36 ring finger protein. (332 aa)
CCL19C-C motif chemokine. (98 aa)
FRMD8FERM domain containing 8. (465 aa)
BCL3BCL3 transcription coactivator. (405 aa)
NFKBIL1NFKB inhibitor like 1. (381 aa)
ARID5AAT-rich interaction domain 5A. (702 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (779 aa)
MIFUncharacterized protein. (115 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
ENSRBIP00000032719SH2 domain-containing protein. (203 aa)
DDX58DExD/H-box helicase 58. (914 aa)
LOC108516810Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (330 aa)
C1QTNF4C1q and TNF related 4. (316 aa)
MC1RMelanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (304 aa)
MAPKAPK2MAPK activated protein kinase 2. (392 aa)
SYT11Synaptotagmin 11. (431 aa)
UBE2J1Ubiquitin conjugating enzyme E2 J1. (317 aa)
DHX9DExH-box helicase 9. (1275 aa)
GSTP1Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa)
ILRUNInflammation and lipid regulator with UBA-like and NBR1-like domains. (263 aa)
IL33Interleukin 33. (269 aa)
LOC108524385Uncharacterized protein. (348 aa)
NLRC3NLR family CARD domain containing 3. (1091 aa)
BPIBactericidal permeability increasing protein. (487 aa)
CD84CD84 molecule. (328 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (570 aa)
DEFB114Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (69 aa)
ARG2Arginase. (354 aa)
ANGPT1Angiopoietin 1. (498 aa)
LBPLipopolysaccharide binding protein. (481 aa)
APPAmyloid beta precursor protein. (770 aa)
CD2CD2 molecule. (351 aa)
PYCARDPYD and CARD domain containing. (195 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (387 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (602 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1310 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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