54 items (Rhinopithecus bieti) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HSPB1	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
	ENSRBIP00000011851	Uncharacterized protein. (107 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (472 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	NLRP3	NLR family pyrin domain containing 3. (1035 aa)
	SMAD3	Mothers against decapentaplegic homolog. (480 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
	TMEM106A	Transmembrane protein 106A. (262 aa)
	FZD5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (443 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (541 aa)
	NLRP2	NLR family pyrin domain containing 2. (1014 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1153 aa)
	NLRC4	NLR family CARD domain containing 4. (1024 aa)
	PANX1	Pannexin; Structural component of the gap junctions and the hemichannels. (426 aa)
	CLEC7A	C-type lectin domain containing 7A. (257 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	IL6	Interleukin 6. (214 aa)
	JAK2	Tyrosine-protein kinase. (1083 aa)
	IL17A	Interleukin 17A. (155 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (542 aa)
	NAIP	NLR family apoptosis inhibitory protein. (1395 aa)
	TLR8	Toll like receptor 8; Belongs to the Toll-like receptor family. (1016 aa)
	LPL	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (529 aa)
	PYDC5	Uncharacterized protein. (101 aa)
	TRIM16	B30.2/SPRY domain-containing protein. (348 aa)
	GSDMD	Gasdermin D. (484 aa)
	CCL19	C-C motif chemokine. (98 aa)
	CASP1	Caspase 1; Belongs to the peptidase C14A family. (404 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (953 aa)
	INAVA	Innate immunity activator. (703 aa)
	LOC108513176	Uncharacterized protein; Belongs to the peptidase C14A family. (406 aa)
	STMP1	Short transmembrane mitochondrial protein 1. (47 aa)
	MEFV	MEFV innate immuity regulator, pyrin. (784 aa)
	LOC108524385	Uncharacterized protein. (348 aa)
	PYDC1	Pyrin domain containing 1. (89 aa)
	NLRP1	NLR family pyrin domain containing 1. (1476 aa)
	APP	Amyloid beta precursor protein. (770 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	AGER	Uncharacterized protein. (417 aa)
	NLRP12	NLR family pyrin domain containing 12. (1055 aa)
	AZU1	Azurocidin 1. (250 aa)
	ENSRBIP00000022247	Uncharacterized protein. (70 aa)
	LILRA5	Uncharacterized protein. (299 aa)
	USP50	Ubiquitin specific peptidase 50; Belongs to the peptidase C19 family. (373 aa)
	IFI16	Interferon gamma inducible protein 16. (729 aa)
	MALT1	MALT1 paracaspase. (811 aa)
	AIM2	Absent in melanoma 2. (343 aa)
	ORM1	Orosomucoid 1. (180 aa)
	ENSRBIP00000013453	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (173 aa)
	PYHIN1	Pyrin and HIN domain family member 1. (492 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGER	APP	ENSRBIP00000023070	ENSRBIP00000038205	Uncharacterized protein.	Amyloid beta precursor protein.	0.520
AIM2	CASP1	ENSRBIP00000015701	ENSRBIP00000031521	Absent in melanoma 2.	Caspase 1; Belongs to the peptidase C14A family.	0.790
AIM2	GSDMD	ENSRBIP00000015701	ENSRBIP00000028056	Absent in melanoma 2.	Gasdermin D.	0.631
AIM2	IFI16	ENSRBIP00000015701	ENSRBIP00000019732	Absent in melanoma 2.	Interferon gamma inducible protein 16.	0.961
AIM2	LOC108513176	ENSRBIP00000015701	ENSRBIP00000035843	Absent in melanoma 2.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.667
AIM2	MEFV	ENSRBIP00000015701	ENSRBIP00000036239	Absent in melanoma 2.	MEFV innate immuity regulator, pyrin.	0.807
AIM2	NAIP	ENSRBIP00000015701	ENSRBIP00000023134	Absent in melanoma 2.	NLR family apoptosis inhibitory protein.	0.684
AIM2	NLRC4	ENSRBIP00000015701	ENSRBIP00000001613	Absent in melanoma 2.	NLR family CARD domain containing 4.	0.705
AIM2	NLRP1	ENSRBIP00000015701	ENSRBIP00000037431	Absent in melanoma 2.	NLR family pyrin domain containing 1.	0.845
AIM2	NLRP12	ENSRBIP00000015701	ENSRBIP00000022982	Absent in melanoma 2.	NLR family pyrin domain containing 12.	0.666
AIM2	NLRP2	ENSRBIP00000015701	ENSRBIP00000003237	Absent in melanoma 2.	NLR family pyrin domain containing 2.	0.625
AIM2	PYCARD	ENSRBIP00000015701	ENSRBIP00000038602	Absent in melanoma 2.	PYD and CARD domain containing.	0.991
AIM2	PYDC1	ENSRBIP00000015701	ENSRBIP00000036955	Absent in melanoma 2.	Pyrin domain containing 1.	0.575
AIM2	TLR4	ENSRBIP00000015701	ENSRBIP00000006333	Absent in melanoma 2.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.611
AIM2	TLR8	ENSRBIP00000015701	ENSRBIP00000024023	Absent in melanoma 2.	Toll like receptor 8; Belongs to the Toll-like receptor family.	0.729
APP	AGER	ENSRBIP00000038205	ENSRBIP00000023070	Amyloid beta precursor protein.	Uncharacterized protein.	0.520
APP	CD36	ENSRBIP00000038205	ENSRBIP00000010002	Amyloid beta precursor protein.	CD36 molecule; Belongs to the CD36 family.	0.479
APP	IL6	ENSRBIP00000038205	ENSRBIP00000041408	Amyloid beta precursor protein.	Interleukin 6.	0.427
APP	LOC108524385	ENSRBIP00000038205	ENSRBIP00000036734	Amyloid beta precursor protein.	Uncharacterized protein.	0.520
APP	ORM1	ENSRBIP00000038205	ENSRBIP00000014145	Amyloid beta precursor protein.	Orosomucoid 1.	0.414