41 items (Rhinopithecus bieti) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

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protein homology

Your Input:
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
	IRF5	Interferon regulatory factor 5. (617 aa)
	IL17A	Interleukin 17A. (155 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	CLEC7A	C-type lectin domain containing 7A. (257 aa)
	IL16	Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1376 aa)
	ENSRBIP00000038500	RHD domain-containing protein. (112 aa)
	LTB	Lymphotoxin beta; Belongs to the tumor necrosis factor family. (244 aa)
	LOC108524385	Uncharacterized protein. (348 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	CD40	CD40 molecule. (278 aa)
	MAPK11	Mitogen-activated protein kinase. (364 aa)
	ENSRBIP00000033881	Uncharacterized protein. (61 aa)
	LOC108516810	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (330 aa)
	IRF8	Interferon regulatory factor 8. (426 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (159 aa)
	CCL19	C-C motif chemokine. (98 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (375 aa)
	IL23A	Interleukin 23 subunit alpha. (189 aa)
	SYK	Uncharacterized protein. (331 aa)
	AGER	Uncharacterized protein. (417 aa)
	ENSRBIP00000022247	Uncharacterized protein. (70 aa)
	ENSRBIP00000021702	Uncharacterized protein. (144 aa)
	TNFSF4	TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
	MDK	Uncharacterized protein. (143 aa)
	TIRAP	TIR domain containing adaptor protein. (233 aa)
	RELA	Uncharacterized protein. (282 aa)
	IDO1	Indoleamine 2,3-dioxygenase 1. (401 aa)
	IL23R	Interleukin 23 receptor. (629 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (472 aa)
	IRF1	Interferon regulatory factor. (325 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (903 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1079 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	ENSRBIP00000006958	TNF receptor-associated factor. (473 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
	SCIMP	SLP adaptor and CSK interacting membrane protein. (143 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (443 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1153 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL19	CCR7	ENSRBIP00000030172	ENSRBIP00000025301	C-C motif chemokine.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.990
CCL19	IFNG	ENSRBIP00000030172	ENSRBIP00000031792	C-C motif chemokine.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.428
CCR7	CCL19	ENSRBIP00000025301	ENSRBIP00000030172	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.990
CCR7	CD40	ENSRBIP00000025301	ENSRBIP00000035450	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	CD40 molecule.	0.622
CCR7	CD40LG	ENSRBIP00000025301	ENSRBIP00000022966	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.516
CCR7	IFNG	ENSRBIP00000025301	ENSRBIP00000031792	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.575
CCR7	LTB	ENSRBIP00000025301	ENSRBIP00000036978	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Lymphotoxin beta; Belongs to the tumor necrosis factor family.	0.498
CD36	CLEC7A	ENSRBIP00000010002	ENSRBIP00000040959	CD36 molecule; Belongs to the CD36 family.	C-type lectin domain containing 7A.	0.441
CD36	TLR4	ENSRBIP00000010002	ENSRBIP00000006333	CD36 molecule; Belongs to the CD36 family.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.872
CD40	CCR7	ENSRBIP00000035450	ENSRBIP00000025301	CD40 molecule.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.622
CD40	CD40LG	ENSRBIP00000035450	ENSRBIP00000022966	CD40 molecule.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.990
CD40	ENSRBIP00000006958	ENSRBIP00000035450	ENSRBIP00000006958	CD40 molecule.	TNF receptor-associated factor.	0.570
CD40	IFNG	ENSRBIP00000035450	ENSRBIP00000031792	CD40 molecule.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.695
CD40	IL17A	ENSRBIP00000035450	ENSRBIP00000041817	CD40 molecule.	Interleukin 17A.	0.449
CD40	LTB	ENSRBIP00000035450	ENSRBIP00000036978	CD40 molecule.	Lymphotoxin beta; Belongs to the tumor necrosis factor family.	0.541
CD40	TLR3	ENSRBIP00000035450	ENSRBIP00000007860	CD40 molecule.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.440
CD40	TLR4	ENSRBIP00000035450	ENSRBIP00000006333	CD40 molecule.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.587
CD40	TNFSF4	ENSRBIP00000035450	ENSRBIP00000019506	CD40 molecule.	TNF superfamily member 4; Belongs to the tumor necrosis factor family.	0.457
CD40	TRAF6	ENSRBIP00000035450	ENSRBIP00000036224	CD40 molecule.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.955
CD40LG	CCR7	ENSRBIP00000022966	ENSRBIP00000025301	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.516