91 items (Rhinopithecus bieti) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (903 aa)
	IL1RL2	Interleukin 1 receptor like 2. (652 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	TSLP	Thymic stromal lymphopoietin. (159 aa)
	ENSRBIP00000006958	TNF receptor-associated factor. (473 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
	AKIRIN2	Akirin 2. (203 aa)
	TMEM106A	Transmembrane protein 106A. (262 aa)
	ENSRBIP00000002079	Uncharacterized protein. (202 aa)
	IL17D	Interleukin 17D. (189 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1153 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (443 aa)
	SCIMP	SLP adaptor and CSK interacting membrane protein. (143 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
	BTK	Tyrosine-protein kinase. (673 aa)
	IL17A	Interleukin 17A. (155 aa)
	BCL10	BCL10 immune signaling adaptor. (233 aa)
	IL6	Interleukin 6. (214 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1126 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	CLEC7A	C-type lectin domain containing 7A. (257 aa)
	RAB7B	RAB7B, member RAS oncogene family. (199 aa)
	IL16	Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1376 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	IL36A	Interleukin-1. (158 aa)
	APP	Amyloid beta precursor protein. (770 aa)
	POU2AF1	POU class 2 homeobox associating factor 1. (257 aa)
	CD74	CD74 molecule. (294 aa)
	LBP	Lipopolysaccharide binding protein. (481 aa)
	LOC108524385	Uncharacterized protein. (348 aa)
	TRPV4	Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
	IL1RAP	Interleukin 1 receptor accessory protein. (680 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	IL33	Interleukin 33. (269 aa)
	DHX9	DExH-box helicase 9. (1275 aa)
	INAVA	Innate immunity activator. (703 aa)
	ADORA2B	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (394 aa)
	C1QTNF4	C1q and TNF related 4. (316 aa)
	LOC108516810	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (330 aa)
	DDX58	DExD/H-box helicase 58. (914 aa)
	MAPK13	Mitogen-activated protein kinase. (365 aa)
	ENSRBIP00000032719	SH2 domain-containing protein. (203 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (953 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (159 aa)
	ARID5A	AT-rich interaction domain 5A. (702 aa)
	IL17RC	Interleukin 17 receptor C. (787 aa)
	TLR9	TIR domain-containing protein. (1033 aa)
	SPON2	Spondin 2. (331 aa)
	ZBTB20	Zinc finger and BTB domain containing 20. (741 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
	MBP	Myelin basic protein. (330 aa)
	ENSRBIP00000026419	Uncharacterized protein. (249 aa)
	F2R	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
	IL17F	Interleukin 17F. (163 aa)
	SPHK2	Sphingosine kinase 2. (658 aa)
	MMP8	Matrix metallopeptidase 8. (465 aa)
	TICAM1	Toll like receptor adaptor molecule 1. (515 aa)
	LPL	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (529 aa)
	TLR8	Toll like receptor 8; Belongs to the Toll-like receptor family. (1016 aa)
	AIF1	Allograft inflammatory factor 1. (147 aa)
	ARHGEF2	Rho/Rac guanine nucleotide exchange factor 2. (1003 aa)
	SYK	Uncharacterized protein. (331 aa)
	AGER	Uncharacterized protein. (417 aa)
	ENSRBIP00000022247	Uncharacterized protein. (70 aa)
	TLR1	Toll like receptor 1. (703 aa)
	LILRA5	Uncharacterized protein. (299 aa)
	XBP1	BZIP domain-containing protein. (380 aa)
	HYAL2	Hyaluronidase. (467 aa)
	MAVS	Mitochondrial antiviral signaling protein. (539 aa)
	TNFSF4	TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
	POU2F2	POU domain protein. (614 aa)
	TIRAP	TIR domain containing adaptor protein. (233 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
	ENSRBIP00000016878	Uncharacterized protein. (251 aa)
	ENSRBIP00000015630	Uncharacterized protein. (49 aa)
	NLRP10	NLR family pyrin domain containing 10. (626 aa)
	IL17RA	Interleukin 17 receptor A. (865 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
	BSG	Basigin (Ok blood group). (385 aa)
	ENSRBIP00000011851	Uncharacterized protein. (107 aa)
	CYBA	Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
	IFIH1	Interferon induced with helicase C domain 1. (1014 aa)
	SETD4	SET domain containing 4. (440 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
	CARD9	Caspase recruitment domain family member 9. (536 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (472 aa)
	ENSRBIP00000009767	Uncharacterized protein. (546 aa)
	IL6R	Interleukin 6 receptor. (499 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	EREG	Epiregulin. (169 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADORA2B	F2R	ENSRBIP00000034455	ENSRBIP00000026002	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family.	0.910
AGER	APP	ENSRBIP00000023070	ENSRBIP00000038205	Uncharacterized protein.	Amyloid beta precursor protein.	0.520
AIF1	APP	ENSRBIP00000024018	ENSRBIP00000038205	Allograft inflammatory factor 1.	Amyloid beta precursor protein.	0.430
AIF1	IL1B	ENSRBIP00000024018	ENSRBIP00000017788	Allograft inflammatory factor 1.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.598
AIF1	IL6	ENSRBIP00000024018	ENSRBIP00000041408	Allograft inflammatory factor 1.	Interleukin 6.	0.475
AIF1	MBP	ENSRBIP00000024018	ENSRBIP00000026494	Allograft inflammatory factor 1.	Myelin basic protein.	0.440
AIF1	PYCARD	ENSRBIP00000024018	ENSRBIP00000038602	Allograft inflammatory factor 1.	PYD and CARD domain containing.	0.454
AKIRIN2	ARHGEF2	ENSRBIP00000005885	ENSRBIP00000023430	Akirin 2.	Rho/Rac guanine nucleotide exchange factor 2.	0.402
APP	AGER	ENSRBIP00000038205	ENSRBIP00000023070	Amyloid beta precursor protein.	Uncharacterized protein.	0.520
APP	AIF1	ENSRBIP00000038205	ENSRBIP00000024018	Amyloid beta precursor protein.	Allograft inflammatory factor 1.	0.430
APP	BTK	ENSRBIP00000038205	ENSRBIP00000042366	Amyloid beta precursor protein.	Tyrosine-protein kinase.	0.478
APP	CD36	ENSRBIP00000038205	ENSRBIP00000010002	Amyloid beta precursor protein.	CD36 molecule; Belongs to the CD36 family.	0.479
APP	CD74	ENSRBIP00000038205	ENSRBIP00000037990	Amyloid beta precursor protein.	CD74 molecule.	0.679
APP	IL1B	ENSRBIP00000038205	ENSRBIP00000017788	Amyloid beta precursor protein.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.475
APP	IL6	ENSRBIP00000038205	ENSRBIP00000041408	Amyloid beta precursor protein.	Interleukin 6.	0.427
APP	LOC108524385	ENSRBIP00000038205	ENSRBIP00000036734	Amyloid beta precursor protein.	Uncharacterized protein.	0.520
APP	MBP	ENSRBIP00000038205	ENSRBIP00000026494	Amyloid beta precursor protein.	Myelin basic protein.	0.455
ARHGEF2	AKIRIN2	ENSRBIP00000023430	ENSRBIP00000005885	Rho/Rac guanine nucleotide exchange factor 2.	Akirin 2.	0.402
BCL10	CARD9	ENSRBIP00000041432	ENSRBIP00000010007	BCL10 immune signaling adaptor.	Caspase recruitment domain family member 9.	0.991
BCL10	CLEC7A	ENSRBIP00000041432	ENSRBIP00000040959	BCL10 immune signaling adaptor.	C-type lectin domain containing 7A.	0.470