96 items (Rhinopithecus bieti) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
	OAS1	2'-5'-oligoadenylate synthetase 1. (408 aa)
	LY96	Lymphocyte antigen 96. (160 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	ENSRBIP00000002079	Uncharacterized protein. (202 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1153 aa)
	AKAP12	A-kinase anchoring protein 12. (1783 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (443 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (432 aa)
	ENSRBIP00000004373	Ig-like domain-containing protein; Belongs to the MHC class I family. (391 aa)
	FZD5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
	TMEM106A	Transmembrane protein 106A. (262 aa)
	DDT	Uncharacterized protein. (143 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	OAS3	2'-5'-oligoadenylate synthetase 3. (1092 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (903 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	ABCC8	ATP binding cassette subfamily C member 8. (1585 aa)
	NFATC4	Nuclear factor of activated T cells 4. (909 aa)
	ENSRBIP00000009767	Uncharacterized protein. (546 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (472 aa)
	CARD9	Caspase recruitment domain family member 9. (536 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
	SETD4	SET domain containing 4. (440 aa)
	IFIH1	Interferon induced with helicase C domain 1. (1014 aa)
	HAVCR2	Hepatitis A virus cellular receptor 2. (294 aa)
	CYBA	Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
	HSPB1	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
	CLU	Clusterin; Belongs to the clusterin family. (515 aa)
	LRRK2	Protein kinase domain-containing protein. (537 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
	ENSRBIP00000013453	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (173 aa)
	ORM1	Orosomucoid 1. (180 aa)
	RASGRP1	RAS guanyl releasing protein 1. (841 aa)
	LOC108539701	Uncharacterized protein. (833 aa)
	ARFGEF2	ADP ribosylation factor guanine nucleotide exchange factor 2. (1785 aa)
	ENSRBIP00000016878	Uncharacterized protein. (251 aa)
	TIRAP	TIR domain containing adaptor protein. (233 aa)
	MAVS	Mitochondrial antiviral signaling protein. (539 aa)
	LILRA5	Uncharacterized protein. (299 aa)
	ENSRBIP00000022247	Uncharacterized protein. (70 aa)
	CD14	CD14 molecule. (384 aa)
	PF4	C-X-C motif chemokine. (101 aa)
	AZU1	Azurocidin 1. (250 aa)
	IFNGR1	Interferon gamma receptor 1. (489 aa)
	AGER	Uncharacterized protein. (417 aa)
	SYK	Uncharacterized protein. (331 aa)
	ARHGEF2	Rho/Rac guanine nucleotide exchange factor 2. (1003 aa)
	IL23A	Interleukin 23 subunit alpha. (189 aa)
	LPL	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (529 aa)
	TICAM1	Toll like receptor adaptor molecule 1. (515 aa)
	HLA-E	Major histocompatibility complex, class I, E; Belongs to the MHC class I family. (359 aa)
	MMP8	Matrix metallopeptidase 8. (465 aa)
	SPHK2	Sphingosine kinase 2. (658 aa)
	OAS2	2'-5'-oligoadenylate synthetase 2. (687 aa)
	CYBB	Cytochrome b-245 beta chain. (513 aa)
	SASH3	SAM and SH3 domain containing 3. (357 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	ENSRBIP00000026419	Uncharacterized protein. (249 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
	ZBTB20	Zinc finger and BTB domain containing 20. (741 aa)
	SPON2	Spondin 2. (331 aa)
	PTPRJ	Protein tyrosine phosphatase receptor type J. (1336 aa)
	CCL19	C-C motif chemokine. (98 aa)
	FRMD8	FERM domain containing 8. (465 aa)
	ARID5A	AT-rich interaction domain 5A. (702 aa)
	MIF	Uncharacterized protein. (115 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (953 aa)
	ENSRBIP00000032719	SH2 domain-containing protein. (203 aa)
	DDX58	DExD/H-box helicase 58. (914 aa)
	LOC108516810	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (330 aa)
	C1QTNF4	C1q and TNF related 4. (316 aa)
	MAPKAPK2	MAPK activated protein kinase 2. (392 aa)
	DHX9	DExH-box helicase 9. (1275 aa)
	IL33	Interleukin 33. (269 aa)
	LOC108524385	Uncharacterized protein. (348 aa)
	CD84	CD84 molecule. (328 aa)
	LBP	Lipopolysaccharide binding protein. (481 aa)
	APP	Amyloid beta precursor protein. (770 aa)
	CD2	CD2 molecule. (351 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1310 aa)
	CLEC7A	C-type lectin domain containing 7A. (257 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	THBS1	Thrombospondin 1. (1170 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (672 aa)
	IL6	Interleukin 6. (214 aa)
	JAK2	Tyrosine-protein kinase. (1083 aa)
	IL17A	Interleukin 17A. (155 aa)
	TNFRSF8	TNF receptor superfamily member 8. (576 aa)
	BTK	Tyrosine-protein kinase. (673 aa)
	ENSRBIP00000043094	Uncharacterized protein. (97 aa)
	EPHB2	EPH receptor B2. (1082 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGER	APP	ENSRBIP00000023070	ENSRBIP00000038205	Uncharacterized protein.	Amyloid beta precursor protein.	0.520
APP	AGER	ENSRBIP00000038205	ENSRBIP00000023070	Amyloid beta precursor protein.	Uncharacterized protein.	0.520
APP	BTK	ENSRBIP00000038205	ENSRBIP00000042366	Amyloid beta precursor protein.	Tyrosine-protein kinase.	0.478
APP	CD36	ENSRBIP00000038205	ENSRBIP00000010002	Amyloid beta precursor protein.	CD36 molecule; Belongs to the CD36 family.	0.479
APP	CLU	ENSRBIP00000038205	ENSRBIP00000012961	Amyloid beta precursor protein.	Clusterin; Belongs to the clusterin family.	0.887
APP	IL6	ENSRBIP00000038205	ENSRBIP00000041408	Amyloid beta precursor protein.	Interleukin 6.	0.427
APP	LOC108524385	ENSRBIP00000038205	ENSRBIP00000036734	Amyloid beta precursor protein.	Uncharacterized protein.	0.520
APP	ORM1	ENSRBIP00000038205	ENSRBIP00000014145	Amyloid beta precursor protein.	Orosomucoid 1.	0.414
APP	PSEN1	ENSRBIP00000038205	ENSRBIP00000004154	Amyloid beta precursor protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.964
AZU1	LBP	ENSRBIP00000022546	ENSRBIP00000037623	Azurocidin 1.	Lipopolysaccharide binding protein.	0.416
BTK	APP	ENSRBIP00000042366	ENSRBIP00000038205	Tyrosine-protein kinase.	Amyloid beta precursor protein.	0.478
BTK	LOC108516810	ENSRBIP00000042366	ENSRBIP00000033438	Tyrosine-protein kinase.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.976
BTK	MYD88	ENSRBIP00000042366	ENSRBIP00000010319	Tyrosine-protein kinase.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.703
BTK	PIK3R1	ENSRBIP00000042366	ENSRBIP00000001603	Tyrosine-protein kinase.	Phosphoinositide-3-kinase regulatory subunit 1.	0.941
BTK	PLCG2	ENSRBIP00000042366	ENSRBIP00000013257	Tyrosine-protein kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.984
BTK	PTPRC	ENSRBIP00000042366	ENSRBIP00000040406	Tyrosine-protein kinase.	Protein tyrosine phosphatase receptor type C.	0.410
BTK	SASH3	ENSRBIP00000042366	ENSRBIP00000025920	Tyrosine-protein kinase.	SAM and SH3 domain containing 3.	0.418
BTK	STAT3	ENSRBIP00000042366	ENSRBIP00000008356	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.692
BTK	SYK	ENSRBIP00000042366	ENSRBIP00000023138	Tyrosine-protein kinase.	Uncharacterized protein.	0.976
BTK	TIRAP	ENSRBIP00000042366	ENSRBIP00000018754	Tyrosine-protein kinase.	TIR domain containing adaptor protein.	0.601