STRINGSTRING
RNF168 RNF168 BRCA2 BRCA2 LOC108544295 LOC108544295 KDM2B KDM2B BCOR BCOR PCGF2 PCGF2 ENSRBIP00000015804 ENSRBIP00000015804 RING1 RING1 DDB1 DDB1 ENSRBIP00000020047 ENSRBIP00000020047 PCGF6 PCGF6 DDB2 DDB2 ENSRBIP00000027334 ENSRBIP00000027334 RYBP RYBP RAD51 RAD51 ENSRBIP00000032723 ENSRBIP00000032723 PCGF3 PCGF3 PCGF5 PCGF5 SKP1 SKP1 TRIM37 TRIM37 PCGF1 PCGF1 ENSRBIP00000039481 ENSRBIP00000039481 ENSRBIP00000039839 ENSRBIP00000039839 BARD1 BARD1 RNF2 RNF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa)
BRCA2Uncharacterized protein. (386 aa)
LOC108544295Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
KDM2BLysine demethylase 2B. (1369 aa)
BCORBCL6 corepressor. (1778 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
ENSRBIP00000015804Cullin domain-containing protein; Belongs to the cullin family. (280 aa)
RING1Ring finger protein 1. (387 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
ENSRBIP00000020047Uncharacterized protein; Belongs to the SKP1 family. (162 aa)
PCGF6Polycomb group ring finger 6. (350 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
ENSRBIP00000027334CULLIN_2 domain-containing protein; Belongs to the cullin family. (299 aa)
RYBPRING1 and YY1 binding protein. (260 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (337 aa)
ENSRBIP00000032723RAWUL domain-containing protein. (144 aa)
PCGF3Polycomb group ring finger 3. (242 aa)
PCGF5Polycomb group ring finger 5. (255 aa)
SKP1Uncharacterized protein; Belongs to the SKP1 family. (154 aa)
TRIM37Tripartite motif containing 37. (951 aa)
PCGF1Polycomb group ring finger 1. (259 aa)
ENSRBIP00000039481RING-type domain-containing protein. (268 aa)
ENSRBIP00000039839Uncharacterized protein; Belongs to the SKP1 family. (129 aa)
BARD1BRCA1 associated RING domain 1. (771 aa)
RNF2Ring finger protein 2. (336 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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