STRINGSTRING
FANCC FANCC FANCI FANCI POLN POLN LOC108532799 LOC108532799 VCP VCP FANCM FANCM ERCC6L2 ERCC6L2 NEIL3 NEIL3 FANCA FANCA FANCD2 FANCD2 MCM9 MCM9 XRCC3 XRCC3 ERCC4 ERCC4 NUCKS1 NUCKS1 DCLRE1B DCLRE1B DCLRE1A DCLRE1A FANCG FANCG FAN1 FAN1 CENPX CENPX FANCL FANCL XPA XPA HROB HROB RFWD3 RFWD3 ATR ATR FAAP100 FAAP100 RNF168 RNF168 RAD51 RAD51 FANCB FANCB SLX4 SLX4 RAD51AP2 RAD51AP2 ENSRBIP00000035711 ENSRBIP00000035711 FAAP24 FAAP24 ERCC1 ERCC1 FANCE FANCE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (558 aa)
FANCIFA complementation group I. (1288 aa)
POLNDNA polymerase nu. (892 aa)
LOC108532799FANCA_interact domain-containing protein. (135 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
FANCMFA complementation group M. (2047 aa)
ERCC6L2ERCC excision repair 6 like 2. (691 aa)
NEIL3Nei like DNA glycosylase 3. (594 aa)
FANCAFA complementation group A. (1375 aa)
FANCD2Uncharacterized protein. (1422 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1140 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (347 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (907 aa)
NUCKS1Nuclear casein kinase and cyclin dependent kinase substrate 1. (232 aa)
DCLRE1BDNA cross-link repair 1B. (532 aa)
DCLRE1ADNA cross-link repair 1A. (1040 aa)
FANCGFA complementation group G. (622 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1017 aa)
CENPXCentromere protein X. (133 aa)
FANCLFA complementation group L. (383 aa)
XPAXPA, DNA damage recognition and repair factor. (303 aa)
HROBChromosome 17 open reading frame 53. (437 aa)
RFWD3Ring finger and WD repeat domain 3. (773 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2578 aa)
FAAP100FA core complex associated protein 100. (881 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (337 aa)
FANCBFA complementation group B. (516 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1814 aa)
RAD51AP2RAD51 associated protein 2. (1159 aa)
ENSRBIP00000035711RAD51_interact domain-containing protein. (282 aa)
FAAP24FA core complex associated protein 24. (215 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (289 aa)
FANCEFA complementation group E. (536 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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