17 items (Rhinopithecus bieti) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	BCL3	BCL3 transcription coactivator. (405 aa)
	TMEM98	Transmembrane protein 98. (226 aa)
	ENSRBIP00000018956	Uncharacterized protein. (216 aa)
	STAT6	Signal transducer and activator of transcription. (847 aa)
	LEF1	Lymphoid enhancer binding factor 1. (398 aa)
	ENSRBIP00000006958	TNF receptor-associated factor. (473 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2527 aa)
	HLX	H2.0 like homeobox. (494 aa)
	RELB	RELB proto-oncogene, NF-kB subunit. (541 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	IL18R1	Interleukin 18 receptor 1. (525 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	SEMA4A	Semaphorin 4A; Belongs to the semaphorin family. (760 aa)
	TBX21	T-box transcription factor 21. (524 aa)
	CRACR2A	Calcium release activated channel regulator 2A. (731 aa)
	IL18BP	Interleukin 18 binding protein. (208 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL3	RELB	ENSRBIP00000031025	ENSRBIP00000031165	BCL3 transcription coactivator.	RELB proto-oncogene, NF-kB subunit.	0.800
ENSRBIP00000006958	RELB	ENSRBIP00000006958	ENSRBIP00000031165	TNF receptor-associated factor.	RELB proto-oncogene, NF-kB subunit.	0.554
HLX	TBX21	ENSRBIP00000002683	ENSRBIP00000040398	H2.0 like homeobox.	T-box transcription factor 21.	0.570
IL18	IL18BP	ENSRBIP00000026957	ENSRBIP00000026788	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin 18 binding protein.	0.873
IL18	IL18R1	ENSRBIP00000026957	ENSRBIP00000040009	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin 18 receptor 1.	0.992
IL18BP	IL18	ENSRBIP00000026788	ENSRBIP00000026957	Interleukin 18 binding protein.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.873
IL18BP	IL18R1	ENSRBIP00000026788	ENSRBIP00000040009	Interleukin 18 binding protein.	Interleukin 18 receptor 1.	0.558
IL18R1	IL18	ENSRBIP00000040009	ENSRBIP00000026957	Interleukin 18 receptor 1.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.992
IL18R1	IL18BP	ENSRBIP00000040009	ENSRBIP00000026788	Interleukin 18 receptor 1.	Interleukin 18 binding protein.	0.558
RELB	BCL3	ENSRBIP00000031165	ENSRBIP00000031025	RELB proto-oncogene, NF-kB subunit.	BCL3 transcription coactivator.	0.800
RELB	ENSRBIP00000006958	ENSRBIP00000031165	ENSRBIP00000006958	RELB proto-oncogene, NF-kB subunit.	TNF receptor-associated factor.	0.554
RELB	TRAF6	ENSRBIP00000031165	ENSRBIP00000036224	RELB proto-oncogene, NF-kB subunit.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.554
STAT6	TBX21	ENSRBIP00000010963	ENSRBIP00000040398	Signal transducer and activator of transcription.	T-box transcription factor 21.	0.575
TBX21	HLX	ENSRBIP00000040398	ENSRBIP00000002683	T-box transcription factor 21.	H2.0 like homeobox.	0.570
TBX21	STAT6	ENSRBIP00000040398	ENSRBIP00000010963	T-box transcription factor 21.	Signal transducer and activator of transcription.	0.575
TRAF6	RELB	ENSRBIP00000036224	ENSRBIP00000031165	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	RELB proto-oncogene, NF-kB subunit.	0.554